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A5V9E5

- LFTR_SPHWW

UniProt

A5V9E5 - LFTR_SPHWW

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Protein

Leucyl/phenylalanyl-tRNA--protein transferase

Gene

aat

Organism
Sphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.UniRule annotation

Catalytic activityi

L-leucyl-tRNA(Leu) + [protein] = tRNA(Leu) + L-leucyl-[protein].UniRule annotation
L-phenylalanyl-tRNA(Phe) + [protein] = tRNA + L-phenylalanyl-[protein].UniRule annotation

GO - Molecular functioni

  1. leucyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

BioCyciSWIT392499:GHZK-2585-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucyl/phenylalanyl-tRNA--protein transferaseUniRule annotation (EC:2.3.2.6UniRule annotation)
Alternative name(s):
L/F-transferaseUniRule annotation
LeucyltransferaseUniRule annotation
PhenyalanyltransferaseUniRule annotation
Gene namesi
Name:aatUniRule annotation
Ordered Locus Names:Swit_2552
OrganismiSphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)
Taxonomic identifieri392499 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeSphingomonas
ProteomesiUP000001989: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 248248Leucyl/phenylalanyl-tRNA--protein transferasePRO_1000083105Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi392499.Swit_2552.

Structurei

3D structure databases

ProteinModelPortaliA5V9E5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the L/F-transferase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2360.
HOGENOMiHOG000102326.
KOiK00684.
OMAiIGHAHSV.
OrthoDBiEOG6WX4R3.

Family and domain databases

HAMAPiMF_00688. Leu_Phe_trans.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR004616. Leu/Phe-tRNA_Trfase.
[Graphical view]
PfamiPF03588. Leu_Phe_trans. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
TIGRFAMsiTIGR00667. aat. 1 hit.

Sequencei

Sequence statusi: Complete.

A5V9E5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKAIDPDLLL RAYSIGVFPM ADSRAADDVY WVEPKKRGIL PLDHFRLSRS
60 70 80 90 100
LAKTIRSDRF AVTADRAFGE VVAECAAVTS QRPDTWINPA IEAAYADLHR
110 120 130 140 150
RGHAHSIECW REGRLVGGLY GVRLGGAFFG ESMFSRESNA SKVALAWLVA
160 170 180 190 200
RLRAGGFRLL DCQFITDHLQ SLGAIEVSRD DYVALLDVAL GVVAGAGAAG
210 220 230 240
GVAVAGAAAG WSAPDFFALD GGATDPDTRT VSGPISGCTI VQLLGQTS
Length:248
Mass (Da):26,351
Last modified:July 10, 2007 - v1
Checksum:iCCDCEE1BA8812B9E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000699 Genomic DNA. Translation: ABQ68911.1.
RefSeqiYP_001263049.1. NC_009511.1.

Genome annotation databases

EnsemblBacteriaiABQ68911; ABQ68911; Swit_2552.
GeneIDi5196559.
KEGGiswi:Swit_2552.
PATRICi23684271. VBISphWit55028_3080.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000699 Genomic DNA. Translation: ABQ68911.1 .
RefSeqi YP_001263049.1. NC_009511.1.

3D structure databases

ProteinModelPortali A5V9E5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 392499.Swit_2552.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ68911 ; ABQ68911 ; Swit_2552 .
GeneIDi 5196559.
KEGGi swi:Swit_2552.
PATRICi 23684271. VBISphWit55028_3080.

Phylogenomic databases

eggNOGi COG2360.
HOGENOMi HOG000102326.
KOi K00684.
OMAi IGHAHSV.
OrthoDBi EOG6WX4R3.

Enzyme and pathway databases

BioCyci SWIT392499:GHZK-2585-MONOMER.

Family and domain databases

HAMAPi MF_00688. Leu_Phe_trans.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR004616. Leu/Phe-tRNA_Trfase.
[Graphical view ]
Pfami PF03588. Leu_Phe_trans. 1 hit.
[Graphical view ]
SUPFAMi SSF55729. SSF55729. 1 hit.
TIGRFAMsi TIGR00667. aat. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RW1 / DSM 6014 / JCM 10273.

Entry informationi

Entry nameiLFTR_SPHWW
AccessioniPrimary (citable) accession number: A5V9E5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 10, 2007
Last modified: October 29, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3