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A5V9E5

- LFTR_SPHWW

UniProt

A5V9E5 - LFTR_SPHWW

Protein

Leucyl/phenylalanyl-tRNA--protein transferase

Gene

aat

Organism
Sphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (10 Jul 2007)
      Previous versions | rss
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    Functioni

    Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.UniRule annotation

    Catalytic activityi

    L-leucyl-tRNA(Leu) + [protein] = tRNA(Leu) + L-leucyl-[protein].UniRule annotation
    L-phenylalanyl-tRNA(Phe) + [protein] = tRNA + L-phenylalanyl-[protein].UniRule annotation

    GO - Molecular functioni

    1. leucyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Enzyme and pathway databases

    BioCyciSWIT392499:GHZK-2585-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucyl/phenylalanyl-tRNA--protein transferaseUniRule annotation (EC:2.3.2.6UniRule annotation)
    Alternative name(s):
    L/F-transferaseUniRule annotation
    LeucyltransferaseUniRule annotation
    PhenyalanyltransferaseUniRule annotation
    Gene namesi
    Name:aatUniRule annotation
    Ordered Locus Names:Swit_2552
    OrganismiSphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)
    Taxonomic identifieri392499 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeSphingomonas
    ProteomesiUP000001989: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 248248Leucyl/phenylalanyl-tRNA--protein transferasePRO_1000083105Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi392499.Swit_2552.

    Structurei

    3D structure databases

    ProteinModelPortaliA5V9E5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the L/F-transferase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2360.
    HOGENOMiHOG000102326.
    KOiK00684.
    OMAiIGHAHSV.
    OrthoDBiEOG6WX4R3.

    Family and domain databases

    HAMAPiMF_00688. Leu_Phe_trans.
    InterProiIPR016181. Acyl_CoA_acyltransferase.
    IPR004616. Leu/Phe-tRNA_Trfase.
    [Graphical view]
    PfamiPF03588. Leu_Phe_trans. 1 hit.
    [Graphical view]
    SUPFAMiSSF55729. SSF55729. 1 hit.
    TIGRFAMsiTIGR00667. aat. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A5V9E5-1 [UniParc]FASTAAdd to Basket

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    MKAIDPDLLL RAYSIGVFPM ADSRAADDVY WVEPKKRGIL PLDHFRLSRS    50
    LAKTIRSDRF AVTADRAFGE VVAECAAVTS QRPDTWINPA IEAAYADLHR 100
    RGHAHSIECW REGRLVGGLY GVRLGGAFFG ESMFSRESNA SKVALAWLVA 150
    RLRAGGFRLL DCQFITDHLQ SLGAIEVSRD DYVALLDVAL GVVAGAGAAG 200
    GVAVAGAAAG WSAPDFFALD GGATDPDTRT VSGPISGCTI VQLLGQTS 248
    Length:248
    Mass (Da):26,351
    Last modified:July 10, 2007 - v1
    Checksum:iCCDCEE1BA8812B9E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000699 Genomic DNA. Translation: ABQ68911.1.
    RefSeqiYP_001263049.1. NC_009511.1.

    Genome annotation databases

    EnsemblBacteriaiABQ68911; ABQ68911; Swit_2552.
    GeneIDi5196559.
    KEGGiswi:Swit_2552.
    PATRICi23684271. VBISphWit55028_3080.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000699 Genomic DNA. Translation: ABQ68911.1 .
    RefSeqi YP_001263049.1. NC_009511.1.

    3D structure databases

    ProteinModelPortali A5V9E5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 392499.Swit_2552.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ68911 ; ABQ68911 ; Swit_2552 .
    GeneIDi 5196559.
    KEGGi swi:Swit_2552.
    PATRICi 23684271. VBISphWit55028_3080.

    Phylogenomic databases

    eggNOGi COG2360.
    HOGENOMi HOG000102326.
    KOi K00684.
    OMAi IGHAHSV.
    OrthoDBi EOG6WX4R3.

    Enzyme and pathway databases

    BioCyci SWIT392499:GHZK-2585-MONOMER.

    Family and domain databases

    HAMAPi MF_00688. Leu_Phe_trans.
    InterProi IPR016181. Acyl_CoA_acyltransferase.
    IPR004616. Leu/Phe-tRNA_Trfase.
    [Graphical view ]
    Pfami PF03588. Leu_Phe_trans. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55729. SSF55729. 1 hit.
    TIGRFAMsi TIGR00667. aat. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RW1 / DSM 6014 / JCM 10273.

    Entry informationi

    Entry nameiLFTR_SPHWW
    AccessioniPrimary (citable) accession number: A5V9E5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3