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A5V6T7 (ACDH1_SPHWW) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acetaldehyde dehydrogenase 1/2

EC=1.2.1.10
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 1/2
Gene names
Ordered Locus Names:Swit_1640
AND
Ordered Locus Names:Swit_2112
OrganismSphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273) [Complete proteome] [HAMAP]
Taxonomic identifier392499 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeSphingomonas

Protein attributes

Sequence length314 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP-Rule MF_01657

Catalytic activity

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP-Rule MF_01657

Sequence similarities

Belongs to the acetaldehyde dehydrogenase family.

Ontologies

Keywords
   Biological processAromatic hydrocarbons catabolism
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processaromatic compound catabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

acetaldehyde dehydrogenase (acetylating) activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 314314Acetaldehyde dehydrogenase 1/2 HAMAP-Rule MF_01657
PRO_0000387743

Regions

Nucleotide binding12 – 154NAD By similarity
Nucleotide binding161 – 1699NAD By similarity

Sites

Active site1301Acyl-thioester intermediate By similarity
Binding site2881NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
A5V6T7 [UniParc].

Last modified July 10, 2007. Version 1.
Checksum: 096763373CD7890D

FASTA31433,111
        10         20         30         40         50         60 
MSQKVKAAII GSGNIGTDLM IKMIKYPQNM ELAAVVGIDP ASEGLAMARE RGIATTHEGI 

        70         80         90        100        110        120 
EGLKKLPDYA EIGVVFDATS AYAHKVHDEA LRADGKLVVD LTPAAIGPFT IPPVNMDEHL 

       130        140        150        160        170        180 
DATNVNMVTC GGQATIPIVA AVSQVATVHY AEIVASVSSR SAGPGTRANI DEFTRTTASA 

       190        200        210        220        230        240 
IEKVGGAAQG KAIIILNPAE PPMIMRDTVF TLSEGADEEA IRASVAAMVA KVQAYVPGYR 

       250        260        270        280        290        300 
LKQEVQFERF GDNNKLKIPG RGEFTGIKTS VFLEVEGAGD YLPSYSGNLD IMTAAAKATG 

       310 
ELLAQRIIER RAAA 

« Hide

References

[1]"Complete sequence of chromosome of Sphingomonas wittichii RW1."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Kim E., Halden R.U., Miller T.R., Salzberg S.L., Eisen J.A., Richardson P.
Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RW1 / DSM 6014 / JCM 10273.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000699 Genomic DNA. Translation: ABQ68003.1.
CP000699 Genomic DNA. Translation: ABQ68471.1.
RefSeqYP_001262141.1. NC_009511.1.
YP_001262609.1. NC_009511.1.

3D structure databases

ProteinModelPortalA5V6T7.
SMRA5V6T7. Positions 1-308.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING392499.Swit_2112.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABQ68003; ABQ68003; Swit_1640.
ABQ68471; ABQ68471; Swit_2112.
GeneID5197132.
5200041.
KEGGswi:Swit_1640.
swi:Swit_2112.
PATRIC23682370. VBISphWit55028_2142.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG4569.
HOGENOMHOG000052149.
OMAFTETTAH.
OrthoDBEOG6H1PXH.

Enzyme and pathway databases

BioCycSWIT392499:GHZK-1661-MONOMER.
SWIT392499:GHZK-2134-MONOMER.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_01657. Ac_ald_DH_ac.
InterProIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNetSearch...

Entry information

Entry nameACDH1_SPHWW
AccessionPrimary (citable) accession number: A5V6T7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: July 10, 2007
Last modified: May 14, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families