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A5V6T7

- ACDH1_SPHWW

UniProt

A5V6T7 - ACDH1_SPHWW

Protein

Acetaldehyde dehydrogenase 1/2

Gene

Swit_1640

more
Organism
Sphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (10 Jul 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

    Catalytic activityi

    Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei130 – 1301Acyl-thioester intermediateUniRule annotation
    Binding sitei288 – 2881NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi12 – 154NADUniRule annotation
    Nucleotide bindingi161 – 1699NADUniRule annotation

    GO - Molecular functioni

    1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
    2. NAD binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. aromatic compound catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Aromatic hydrocarbons catabolism

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciSWIT392499:GHZK-1661-MONOMER.
    SWIT392499:GHZK-2134-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetaldehyde dehydrogenase 1/2UniRule annotation (EC:1.2.1.10UniRule annotation)
    Alternative name(s):
    Acetaldehyde dehydrogenase [acetylating] 1/2UniRule annotation
    Gene namesi
    Ordered Locus Names:Swit_1640
    AND
    Ordered Locus Names:Swit_2112
    OrganismiSphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)
    Taxonomic identifieri392499 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeSphingomonas
    ProteomesiUP000001989: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 314314Acetaldehyde dehydrogenase 1/2PRO_0000387743Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi392499.Swit_2112.

    Structurei

    3D structure databases

    ProteinModelPortaliA5V6T7.
    SMRiA5V6T7. Positions 1-308.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG4569.
    HOGENOMiHOG000052149.
    KOiK04073.
    OMAiFTETTAH.
    OrthoDBiEOG6H1PXH.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_01657. Ac_ald_DH_ac.
    InterProiIPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view]
    PfamiPF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTiSM00859. Semialdhyde_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A5V6T7-1 [UniParc]FASTAAdd to Basket

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    MSQKVKAAII GSGNIGTDLM IKMIKYPQNM ELAAVVGIDP ASEGLAMARE    50
    RGIATTHEGI EGLKKLPDYA EIGVVFDATS AYAHKVHDEA LRADGKLVVD 100
    LTPAAIGPFT IPPVNMDEHL DATNVNMVTC GGQATIPIVA AVSQVATVHY 150
    AEIVASVSSR SAGPGTRANI DEFTRTTASA IEKVGGAAQG KAIIILNPAE 200
    PPMIMRDTVF TLSEGADEEA IRASVAAMVA KVQAYVPGYR LKQEVQFERF 250
    GDNNKLKIPG RGEFTGIKTS VFLEVEGAGD YLPSYSGNLD IMTAAAKATG 300
    ELLAQRIIER RAAA 314
    Length:314
    Mass (Da):33,111
    Last modified:July 10, 2007 - v1
    Checksum:i096763373CD7890D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000699 Genomic DNA. Translation: ABQ68003.1.
    CP000699 Genomic DNA. Translation: ABQ68471.1.
    RefSeqiWP_011952481.1. NC_009511.1.
    YP_001262141.1. NC_009511.1.
    YP_001262609.1. NC_009511.1.

    Genome annotation databases

    EnsemblBacteriaiABQ68003; ABQ68003; Swit_1640.
    ABQ68471; ABQ68471; Swit_2112.
    GeneIDi5197132.
    5200041.
    KEGGiswi:Swit_1640.
    swi:Swit_2112.
    PATRICi23682370. VBISphWit55028_2142.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000699 Genomic DNA. Translation: ABQ68003.1 .
    CP000699 Genomic DNA. Translation: ABQ68471.1 .
    RefSeqi WP_011952481.1. NC_009511.1.
    YP_001262141.1. NC_009511.1.
    YP_001262609.1. NC_009511.1.

    3D structure databases

    ProteinModelPortali A5V6T7.
    SMRi A5V6T7. Positions 1-308.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 392499.Swit_2112.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ68003 ; ABQ68003 ; Swit_1640 .
    ABQ68471 ; ABQ68471 ; Swit_2112 .
    GeneIDi 5197132.
    5200041.
    KEGGi swi:Swit_1640.
    swi:Swit_2112.
    PATRICi 23682370. VBISphWit55028_2142.

    Phylogenomic databases

    eggNOGi COG4569.
    HOGENOMi HOG000052149.
    KOi K04073.
    OMAi FTETTAH.
    OrthoDBi EOG6H1PXH.

    Enzyme and pathway databases

    BioCyci SWIT392499:GHZK-1661-MONOMER.
    SWIT392499:GHZK-2134-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_01657. Ac_ald_DH_ac.
    InterProi IPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view ]
    Pfami PF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTi SM00859. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RW1 / DSM 6014 / JCM 10273.

    Entry informationi

    Entry nameiACDH1_SPHWW
    AccessioniPrimary (citable) accession number: A5V6T7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 3, 2009
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3