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Protein

Acetaldehyde dehydrogenase 1/2

Gene

Swit_1640

more
Organism
Sphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei130Acyl-thioester intermediateUniRule annotation1
Binding sitei288NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 15NADUniRule annotation4
Nucleotide bindingi161 – 169NADUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAromatic hydrocarbons catabolism
LigandNAD

Enzyme and pathway databases

BioCyciSWIT392499:GHZK-1652-MONOMER
SWIT392499:GHZK-2121-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 1/2UniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 1/2UniRule annotation
Gene namesi
Ordered Locus Names:Swit_1640
AND
Ordered Locus Names:Swit_2112
OrganismiSphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)
Taxonomic identifieri392499 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeSphingomonas
Proteomesi
  • UP000001989 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003877431 – 314Acetaldehyde dehydrogenase 1/2Add BLAST314

Interactioni

Protein-protein interaction databases

STRINGi392499.Swit_2112

Structurei

3D structure databases

ProteinModelPortaliA5V6T7
SMRiA5V6T7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DIV Bacteria
COG4569 LUCA
HOGENOMiHOG000052149
KOiK04073
OMAiIMMHNTI
OrthoDBiPOG091H09NP

Family and domain databases

HAMAPiMF_01657 Ac_ald_DH_ac, 1 hit
InterProiView protein in InterPro
IPR003361 Acetaldehyde_dehydrogenase
IPR015426 Acetylaldehyde_DH_C
IPR036291 NAD(P)-bd_dom_sf
IPR000534 Semialdehyde_DH_NAD-bd
PfamiView protein in Pfam
PF09290 AcetDehyd-dimer, 1 hit
PF01118 Semialdhyde_dh, 1 hit
PIRSFiPIRSF015689 Actaldh_dh_actl, 1 hit
SMARTiView protein in SMART
SM00859 Semialdhyde_dh, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR03215 ac_ald_DH_ac, 1 hit

Sequencei

Sequence statusi: Complete.

A5V6T7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQKVKAAII GSGNIGTDLM IKMIKYPQNM ELAAVVGIDP ASEGLAMARE
60 70 80 90 100
RGIATTHEGI EGLKKLPDYA EIGVVFDATS AYAHKVHDEA LRADGKLVVD
110 120 130 140 150
LTPAAIGPFT IPPVNMDEHL DATNVNMVTC GGQATIPIVA AVSQVATVHY
160 170 180 190 200
AEIVASVSSR SAGPGTRANI DEFTRTTASA IEKVGGAAQG KAIIILNPAE
210 220 230 240 250
PPMIMRDTVF TLSEGADEEA IRASVAAMVA KVQAYVPGYR LKQEVQFERF
260 270 280 290 300
GDNNKLKIPG RGEFTGIKTS VFLEVEGAGD YLPSYSGNLD IMTAAAKATG
310
ELLAQRIIER RAAA
Length:314
Mass (Da):33,111
Last modified:July 10, 2007 - v1
Checksum:i096763373CD7890D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000699 Genomic DNA Translation: ABQ68003.1
CP000699 Genomic DNA Translation: ABQ68471.1
RefSeqiWP_011952481.1, NC_009511.1

Genome annotation databases

EnsemblBacteriaiABQ68003; ABQ68003; Swit_1640
ABQ68471; ABQ68471; Swit_2112
KEGGiswi:Swit_1640
swi:Swit_2112

Similar proteinsi

Entry informationi

Entry nameiACDH1_SPHWW
AccessioniPrimary (citable) accession number: A5V6T7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: July 10, 2007
Last modified: May 23, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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