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Protein

Acetaldehyde dehydrogenase 1/2

Gene

Swit_1640

more
Organism
Sphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei130 – 1301Acyl-thioester intermediateUniRule annotation
Binding sitei288 – 2881NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 154NADUniRule annotation
Nucleotide bindingi161 – 1699NADUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciSWIT392499:GHZK-1661-MONOMER.
SWIT392499:GHZK-2134-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 1/2UniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 1/2UniRule annotation
Gene namesi
Ordered Locus Names:Swit_1640
AND
Ordered Locus Names:Swit_2112
OrganismiSphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)
Taxonomic identifieri392499 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeSphingomonas
ProteomesiUP000001989 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Acetaldehyde dehydrogenase 1/2PRO_0000387743Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi392499.Swit_2112.

Structurei

3D structure databases

ProteinModelPortaliA5V6T7.
SMRiA5V6T7. Positions 1-308.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG4569.
HOGENOMiHOG000052149.
KOiK04073.
OMAiIATTHEG.
OrthoDBiEOG6H1PXH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

A5V6T7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQKVKAAII GSGNIGTDLM IKMIKYPQNM ELAAVVGIDP ASEGLAMARE
60 70 80 90 100
RGIATTHEGI EGLKKLPDYA EIGVVFDATS AYAHKVHDEA LRADGKLVVD
110 120 130 140 150
LTPAAIGPFT IPPVNMDEHL DATNVNMVTC GGQATIPIVA AVSQVATVHY
160 170 180 190 200
AEIVASVSSR SAGPGTRANI DEFTRTTASA IEKVGGAAQG KAIIILNPAE
210 220 230 240 250
PPMIMRDTVF TLSEGADEEA IRASVAAMVA KVQAYVPGYR LKQEVQFERF
260 270 280 290 300
GDNNKLKIPG RGEFTGIKTS VFLEVEGAGD YLPSYSGNLD IMTAAAKATG
310
ELLAQRIIER RAAA
Length:314
Mass (Da):33,111
Last modified:July 10, 2007 - v1
Checksum:i096763373CD7890D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000699 Genomic DNA. Translation: ABQ68003.1.
CP000699 Genomic DNA. Translation: ABQ68471.1.
RefSeqiWP_011952481.1. NC_009511.1.

Genome annotation databases

EnsemblBacteriaiABQ68003; ABQ68003; Swit_1640.
ABQ68471; ABQ68471; Swit_2112.
KEGGiswi:Swit_1640.
swi:Swit_2112.
PATRICi23682370. VBISphWit55028_2142.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000699 Genomic DNA. Translation: ABQ68003.1.
CP000699 Genomic DNA. Translation: ABQ68471.1.
RefSeqiWP_011952481.1. NC_009511.1.

3D structure databases

ProteinModelPortaliA5V6T7.
SMRiA5V6T7. Positions 1-308.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi392499.Swit_2112.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABQ68003; ABQ68003; Swit_1640.
ABQ68471; ABQ68471; Swit_2112.
KEGGiswi:Swit_1640.
swi:Swit_2112.
PATRICi23682370. VBISphWit55028_2142.

Phylogenomic databases

eggNOGiCOG4569.
HOGENOMiHOG000052149.
KOiK04073.
OMAiIATTHEG.
OrthoDBiEOG6H1PXH.

Enzyme and pathway databases

BioCyciSWIT392499:GHZK-1661-MONOMER.
SWIT392499:GHZK-2134-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RW1 / DSM 6014 / JCM 10273.

Entry informationi

Entry nameiACDH1_SPHWW
AccessioniPrimary (citable) accession number: A5V6T7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: July 10, 2007
Last modified: July 22, 2015
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.