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A5V6T7

- ACDH1_SPHWW

UniProt

A5V6T7 - ACDH1_SPHWW

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Protein

Acetaldehyde dehydrogenase 1/2

Gene
Swit_1640
Swit_2112
Organism
Sphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei130 – 1301Acyl-thioester intermediate By similarity
Binding sitei288 – 2881NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 154NAD By similarity
Nucleotide bindingi161 – 1699NAD By similarity

GO - Molecular functioni

  1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
  2. NAD binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciSWIT392499:GHZK-1661-MONOMER.
SWIT392499:GHZK-2134-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 1/2 (EC:1.2.1.10)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 1/2
Gene namesi
Ordered Locus Names:Swit_1640
AND
Ordered Locus Names:Swit_2112
OrganismiSphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)
Taxonomic identifieri392499 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeSphingomonas
ProteomesiUP000001989: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Acetaldehyde dehydrogenase 1/2UniRule annotationPRO_0000387743Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi392499.Swit_2112.

Structurei

3D structure databases

ProteinModelPortaliA5V6T7.
SMRiA5V6T7. Positions 1-308.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG4569.
HOGENOMiHOG000052149.
KOiK04073.
OMAiFTETTAH.
OrthoDBiEOG6H1PXH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

A5V6T7-1 [UniParc]FASTAAdd to Basket

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MSQKVKAAII GSGNIGTDLM IKMIKYPQNM ELAAVVGIDP ASEGLAMARE    50
RGIATTHEGI EGLKKLPDYA EIGVVFDATS AYAHKVHDEA LRADGKLVVD 100
LTPAAIGPFT IPPVNMDEHL DATNVNMVTC GGQATIPIVA AVSQVATVHY 150
AEIVASVSSR SAGPGTRANI DEFTRTTASA IEKVGGAAQG KAIIILNPAE 200
PPMIMRDTVF TLSEGADEEA IRASVAAMVA KVQAYVPGYR LKQEVQFERF 250
GDNNKLKIPG RGEFTGIKTS VFLEVEGAGD YLPSYSGNLD IMTAAAKATG 300
ELLAQRIIER RAAA 314
Length:314
Mass (Da):33,111
Last modified:July 10, 2007 - v1
Checksum:i096763373CD7890D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000699 Genomic DNA. Translation: ABQ68003.1.
CP000699 Genomic DNA. Translation: ABQ68471.1.
RefSeqiWP_011952481.1. NC_009511.1.
YP_001262141.1. NC_009511.1.
YP_001262609.1. NC_009511.1.

Genome annotation databases

EnsemblBacteriaiABQ68003; ABQ68003; Swit_1640.
ABQ68471; ABQ68471; Swit_2112.
GeneIDi5197132.
5200041.
KEGGiswi:Swit_1640.
swi:Swit_2112.
PATRICi23682370. VBISphWit55028_2142.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000699 Genomic DNA. Translation: ABQ68003.1 .
CP000699 Genomic DNA. Translation: ABQ68471.1 .
RefSeqi WP_011952481.1. NC_009511.1.
YP_001262141.1. NC_009511.1.
YP_001262609.1. NC_009511.1.

3D structure databases

ProteinModelPortali A5V6T7.
SMRi A5V6T7. Positions 1-308.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 392499.Swit_2112.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ68003 ; ABQ68003 ; Swit_1640 .
ABQ68471 ; ABQ68471 ; Swit_2112 .
GeneIDi 5197132.
5200041.
KEGGi swi:Swit_1640.
swi:Swit_2112.
PATRICi 23682370. VBISphWit55028_2142.

Phylogenomic databases

eggNOGi COG4569.
HOGENOMi HOG000052149.
KOi K04073.
OMAi FTETTAH.
OrthoDBi EOG6H1PXH.

Enzyme and pathway databases

BioCyci SWIT392499:GHZK-1661-MONOMER.
SWIT392499:GHZK-2134-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01657. Ac_ald_DH_ac.
InterProi IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view ]
Pfami PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTi SM00859. Semialdhyde_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RW1 / DSM 6014 / JCM 10273.

Entry informationi

Entry nameiACDH1_SPHWW
AccessioniPrimary (citable) accession number: A5V6T7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: July 10, 2007
Last modified: September 3, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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