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Protein

NAD kinase

Gene

nadK

Organism
Sphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei44Proton acceptorUniRule annotation1
Binding sitei49NADUniRule annotation1
Binding sitei146NADUniRule annotation1
Binding sitei154NAD; via carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi44 – 45NADUniRule annotation2
Nucleotide bindingi116 – 117NADUniRule annotation2
Nucleotide bindingi157 – 162NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:Swit_1521
OrganismiSphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)
Taxonomic identifieri392499 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeSphingomonas
Proteomesi
  • UP000001989 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000054431 – 257NAD kinaseAdd BLAST257

Proteomic databases

PRIDEiA5V6G8

Interactioni

Protein-protein interaction databases

STRINGi392499.Swit_1521

Structurei

3D structure databases

ProteinModelPortaliA5V6G8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F91 Bacteria
COG0061 LUCA
HOGENOMiHOG000139847
KOiK00858
OMAiNGIERMS
OrthoDBiPOG091H02D1

Family and domain databases

Gene3Di2.60.200.30, 1 hit
3.40.50.10330, 1 hit
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PANTHERiPTHR20275 PTHR20275, 1 hit
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

A5V6G8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEQRMALVA SPTTAAQEAA TELRAIYEWH PIERADLVVA LGGDGFMLRT
60 70 80 90 100
LHAMLDRHRI LPVFGMNLGT VGFLMNDWKP DLLELRLQQA RAITVLPLRM
110 120 130 140 150
DVETVEGQRH SVPAINEVSL LRETRETAKI EVLVDGRVVL PELVCDGVLV
160 170 180 190 200
STPAGSTAYN LSAQGPILPL ESSLLALTPI SPFRPRRWRG AILPNKNAIS
210 220 230 240 250
FRVLDAIKRP VSAVADQREV RDVSLIRVGI DKTSPLTLLF DPEHALDDRI

TMEQFAV
Length:257
Mass (Da):28,479
Last modified:July 10, 2007 - v1
Checksum:iE033FA09504CEB68
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000699 Genomic DNA Translation: ABQ67884.1
RefSeqiWP_011952362.1, NC_009511.1

Genome annotation databases

EnsemblBacteriaiABQ67884; ABQ67884; Swit_1521
KEGGiswi:Swit_1521

Similar proteinsi

Entry informationi

Entry nameiNADK_SPHWW
AccessioniPrimary (citable) accession number: A5V6G8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 10, 2007
Last modified: May 23, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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