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Protein

Malate dehydrogenase

Gene

mdh

Organism
Sphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei34NAD1
Binding sitei83Substrate1
Binding sitei89Substrate1
Binding sitei96NAD1
Binding sitei121Substrate1
Binding sitei152Substrate1
Active sitei176Proton acceptor1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 15NAD6
Nucleotide bindingi119 – 121NAD3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase (EC:1.1.1.37)
Gene namesi
Name:mdh
Ordered Locus Names:Swit_1300
OrganismiSphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)
Taxonomic identifieri392499 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeSphingomonas
Proteomesi
  • UP000001989 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000264951 – 320Malate dehydrogenaseAdd BLAST320

Proteomic databases

PRIDEiA5V5U9.

Interactioni

Protein-protein interaction databases

STRINGi392499.Swit_1300.

Structurei

3D structure databases

ProteinModelPortaliA5V5U9.
SMRiA5V5U9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.

Phylogenomic databases

eggNOGiENOG4105C80. Bacteria.
COG0039. LUCA.
HOGENOMiHOG000213794.
KOiK00024.
OMAiICIIANP.
OrthoDBiPOG091H02N6.

Family and domain databases

CDDicd01339. LDH-like_MDH. 1 hit.
Gene3Di3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3. 1 hit.
InterProiView protein in InterPro
IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR036291. NAD(P)-bd_dom_sf.
PfamiView protein in Pfam
PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

A5V5U9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARTKIALIG AGNIGGTLAH LAASKELGDV VLFDVVEGVP QGKALDLSQC
60 70 80 90 100
GPVEGFDAKL KGTNDYADIA GADVIIVTAG VARKPGMSRD DLLGINLKVM
110 120 130 140 150
KSVGEGIKAN APDAFVICIT NPLDAMVWAL REFSGLPHNK VVGMAGVLDS
160 170 180 190 200
ARFATFLAEE FNVSVQDVTT FVLGGHGDTM VPVVEYSTVA GIPIPDLIKM
210 220 230 240 250
GWSTQERIDA IVQRTRSGGG EIVALLKTGS AFYAPATSAI AMAESYLKDK
260 270 280 290 300
KRVLPCAAYL SGEYGVDDLY VGVPVIIGAN GVEKIVEINL SDSAKANLQV
310 320
SVDAVKELLV ACKGIDSSLA
Length:320
Mass (Da):33,337
Last modified:July 10, 2007 - v1
Checksum:i929A0EDEB34574DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000699 Genomic DNA. Translation: ABQ67665.1.
RefSeqiWP_011952143.1. NC_009511.1.

Genome annotation databases

EnsemblBacteriaiABQ67665; ABQ67665; Swit_1300.
KEGGiswi:Swit_1300.

Similar proteinsi

Entry informationi

Entry nameiMDH_SPHWW
AccessioniPrimary (citable) accession number: A5V5U9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 10, 2007
Last modified: October 25, 2017
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families