A5V4F9 (DADA_SPHWW) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
D-amino acid dehydrogenase small subunit
EC=1.4.99.1

Gene names

Name:	dadA
Ordered Locus Names:	Swit_0808

Organism

Sphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273) [Complete proteome] [HAMAP]

Taxonomic identifier

392499 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Sphingomonadales › Sphingomonadaceae › Sphingomonas

Protein attributes

Sequence length	416 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Oxidative deamination of D-amino acids By similarity. HAMAP MF_01202
Catalytic activity	A D-amino acid + H2O + acceptor = a 2-oxo acid + NH3 + reduced acceptor. HAMAP MF_01202
Cofactor	FAD By similarity. HAMAP MF_01202
Pathway	Amino-acid degradation; D-alanine degradation; NH(3) and pyruvate from D-alanine: step 1/1. HAMAP MF_01202
Subunit structure	Heterodimer of a small and a large subunit By similarity.
Sequence similarities	Belongs to the DadA oxidoreductase family.

Ontologies

Keywords
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	D-amino-acid dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 416	416	D-amino acid dehydrogenase small subunit HAMAP MF_01202		PRO_1000066121
Regions
	Nucleotide binding	3 – 17	15	FAD Potential

Sequences

	Sequence		Length	Mass (Da)
	A5V4F9 [UniParc]. Last modified July 10, 2007. Version 1. Checksum: A19CFEBF99022256	FASTA	416	44,460
	10 20 30 40 50 60 MKVVILGAGV IGVTSAWYLA RAGHEVVVVD RQDGPALETS FANAGEISPG YASPWAAPGI 70 80 90 100 110 120 PAKALRWLFM RHAPLIVRPG FDPAMVRWLV AMLGNCTARA YRVNKGRMVR LAEFSRDRLI 130 140 150 160 170 180 ELRQETGIRY DERSQGTLQL FRREKDLAGV AKDIEVLKAD GVPFELLDAA GCIAAEPGLA 190 200 210 220 230 240 NSASPIAGGL RLPNDETGDC FKFTNALAEL AKAEGVRFVL GRRIDAIVAS GNRIAHVRTD 250 260 270 280 290 300 RGDISGDAYL VALGSHSPLL LSPLGIRLPV YPVKGYSITV PIVDPARAPV STLLDESFKV 310 320 330 340 350 360 AITRLGDRIR VGGMAEISGY SNDLPPARRA TLDHCVGSLF PDAGDLSQAS FWTGLRPMTP 370 380 390 400 410 DGTPVIGATG YRNLFLNTGH GTLGWTMACG SGHVIADIIG GKRPAIETGD LAIDRY

References

[1]

"Complete sequence of chromosome of Sphingomonas wittichii RW1." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Kim E., Halden R.U., Miller T.R., Salzberg S.L., Eisen J.A., Richardson P. Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RW1 / DSM 6014 / JCM 10273.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000699 Genomic DNA. Translation: ABQ67175.1.
RefSeq	YP_001261313.1. NC_009511.1.
3D structure databases
ProteinModelPortal	A5V4F9.
ModBase	Search...
Protein-protein interaction databases
STRING	A5V4F9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5197426.
GenomeReviews	Gene locus Swit_0808 in contig CP000699_GR.
KEGG	swi:Swit_0808.
NMPDR	fig|392499.4.peg.1129.
PATRIC	23680638. VBISphWit55028_1284.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0665.
HOGENOM	HBG729204.
OMA	LEHAGGQ.
Family and domain databases
HAMAP	MF_01202. DadA. [Tree]
InterPro	IPR023080. D-aa_DH_ssu_DadA. IPR006076. FAD-dep_OxRdtase. [Graphical view]
KO	K00285.
Pfam	PF01266. DAO. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DADA_SPHWW

Accession

Primary (citable) accession number: A5V4F9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	July 10, 2007
Last modified:	January 25, 2012
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program