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A5V4F8

- A5V4F8_SPHWW

UniProt

A5V4F8 - A5V4F8_SPHWW

Protein

Alanine racemase

Gene

Swit_0807

Organism
Sphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (10 Jul 2007)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei40 – 401Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei139 – 1391SubstrateUniRule annotation
    Active sitei260 – 2601Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei308 – 3081Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciSWIT392499:GHZK-820-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Ordered Locus Names:Swit_0807Imported
    OrganismiSphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)Imported
    Taxonomic identifieri392499 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeSphingomonas
    ProteomesiUP000001989: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei40 – 401N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi392499.Swit_0807.

    Structurei

    3D structure databases

    ProteinModelPortaliA5V4F8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0787.
    HOGENOMiHOG000031445.
    KOiK01775.
    OMAiFIMSHLA.
    OrthoDBiEOG6PP9NJ.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5V4F8-1 [UniParc]FASTAAdd to Basket

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    MTANDAAAGA ILRIDLDAII DNYRLIQQRA APAEVAAVVK ADAYGLGAAR    50
    VAAALRDAGC RRFFVAHLVE AARLREAIGD GVEIGVLNGL QPGAETACAE 100
    LGAVPVLNAL DQIERWAALA RASSARLPCM IQFDTGMSRL GLAPGEVRAL 150
    IDRPERLDGL DIRLIMSHLA CADEPERASN QHQAQAFDAF CARFPGIPRS 200
    LDNSGGALLP RAHHYDVVRA GIALYGGAPQ TGPNPMRPVV TLDARVIQLR 250
    TVEPGTAVGY GLTHRFDRPA RLATLSVGYA DGWPRSLGNR GAAYVAGHRA 300
    PIVGRISMDS LTIDVSDIPE ELLLPGSLIE LIGPHQSIDD VARDAGTISY 350
    EILTQLGHRY ARSYLPSPSL HQQKAAQA 378
    Length:378
    Mass (Da):40,224
    Last modified:July 10, 2007 - v1
    Checksum:i45174E0DFCC5732C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000699 Genomic DNA. Translation: ABQ67174.1.
    RefSeqiWP_011951654.1. NC_009511.1.
    YP_001261312.1. NC_009511.1.

    Genome annotation databases

    EnsemblBacteriaiABQ67174; ABQ67174; Swit_0807.
    GeneIDi5197425.
    KEGGiswi:Swit_0807.
    PATRICi23680636. VBISphWit55028_1283.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000699 Genomic DNA. Translation: ABQ67174.1 .
    RefSeqi WP_011951654.1. NC_009511.1.
    YP_001261312.1. NC_009511.1.

    3D structure databases

    ProteinModelPortali A5V4F8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 392499.Swit_0807.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ67174 ; ABQ67174 ; Swit_0807 .
    GeneIDi 5197425.
    KEGGi swi:Swit_0807.
    PATRICi 23680636. VBISphWit55028_1283.

    Phylogenomic databases

    eggNOGi COG0787.
    HOGENOMi HOG000031445.
    KOi K01775.
    OMAi FIMSHLA.
    OrthoDBi EOG6PP9NJ.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci SWIT392499:GHZK-820-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RW1 / DSM 6014 / JCM 10273Imported.

    Entry informationi

    Entry nameiA5V4F8_SPHWW
    AccessioniPrimary (citable) accession number: A5V4F8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 10, 2007
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3