A5V439 (A5V439_SPHWW) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Acetyl-coenzyme A synthetase 1 HAMAP MF_01123
EC=6.2.1.1 HAMAP MF_01123

Alternative name(s):
Acetate--CoA ligase 1 HAMAP MF_01123
Acyl-activating enzyme 1 HAMAP MF_01123

Gene names

Name:	acsA1 HAMAP MF_01123
Ordered Locus Names:	Swit_0688

Organism

Sphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273) [Complete proteome] [HAMAP]

Taxonomic identifier

392499 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Sphingomonadales › Sphingomonadaceae › Sphingomonas

Protein attributes

Sequence length	651 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. HAMAP MF_01123
Post-translational modification	Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme By similarity. HAMAP MF_01123
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family. HAMAP MF_01123

Ontologies

Keywords
Ligand	ATP-binding HAMAP MF_01123 Nucleotide-binding
Molecular function	Ligase HAMAP MF_01123 EMBL ABQ67055.1
PTM	Acetylation HAMAP MF_01123
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	AMP binding Inferred from electronic annotation. Source: InterPro ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate-CoA ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	515	1	By similarity HAMAP MF_01123
Amino acid modifications
	Modified residue	607	1	N6-acetyllysine By similarity HAMAP MF_01123

Sequences

	Sequence		Length	Mass (Da)
	A5V439 [UniParc]. Last modified July 10, 2007. Version 1. Checksum: 049685E8FE82D939	FASTA	651	71,186
	10 20 30 40 50 60 MADHLYPVPA SWAAKSRMNA AERAADHALS LAAPGRYWLD RAARLDWFRF PTRADESSFD 70 80 90 100 110 120 EADFQVKWFA DGALNVSVNC IDRHLAGHGD DVAILWEPDD PAEAPRRFTY AQLHAEVCRL 130 140 150 160 170 180 ANVLKAQGVR KGHRVTIYLP MIPEAAFALL ACARIGAIHS VVFGGFSPDA LAGRIQDCDS 190 200 210 220 230 240 SVVVTADHGR RGGKLVPLKA NVDEALRQCT SVEAVVVVRA TGGAVEMVPG RDVWLDEAVR 250 260 270 280 290 300 HVAADCPAEP MNAEDPLFIL YTSGSTGKPK GVVHTSGGYL LWASLTHELC FDYRRGEVFW 310 320 330 340 350 360 CSADIGWVTG HSYIVYGPLA NGATTLIYEG VPNWPDASRM WEVVDRHGVH TLFTAPTALR 370 380 390 400 410 420 ALMREGDDYV TGTSRKSLRL LGTVGEPINP EAWRWYHEVV GEGRCPIVDT WWQTETGAAM 430 440 450 460 470 480 IAPLPGATAL KPGSATLPMP GVAPELVDAE GRPVEGAGEG NLCITRSWPG QMRTVWNDHA 490 500 510 520 530 540 RFFQTYFSTY KGKYFTGDGC RRDEDGYYWI TGRVDDVINV SGHRMGTAEV ESALVLHAKV 550 560 570 580 590 600 AEAAVVGFPH DIKGQGIYAY VTLNAGEEAS EDLRKELRDW VRTEIGPIAT PDAIQFAPGL 610 620 630 640 650 PKTRSGKIMR RILRKIAEGD VSPLGDTSTL ADPAVVEHLV DNRIIAERPK V

References

[1]

"Complete sequence of chromosome of Sphingomonas wittichii RW1." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Kim E., Halden R.U., Miller T.R., Salzberg S.L., Eisen J.A., Richardson P. Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RW1 / DSM 6014 / JCM 10273.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000699 Genomic DNA. Translation: ABQ67055.1.
RefSeq	YP_001261193.1. NC_009511.1.
3D structure databases
ProteinModelPortal	A5V439.
SMR	A5V439. Positions 4-643.
ModBase	Search...
Protein-protein interaction databases
STRING	A5V439.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5200987.
GenomeReviews	Gene locus Swit_0688 in contig CP000699_GR.
KEGG	swi:Swit_0688.
NMPDR	fig|392499.4.peg.1012.
PATRIC	23680388. VBISphWit55028_1159.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0365.
HOGENOM	HBG547964.
OMA	EMEGECS.
ProtClustDB	CLSK857048.
Family and domain databases
HAMAP	MF_01123. Ac_CoA_synth. [Tree]
InterPro	IPR011904. Ac_CoA_lig. IPR024597. Acyl-CoA_synth_DUF3448. IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. [Graphical view]
KO	K01895.
PANTHER	PTHR24095:SF42. PTHR24095:SF42. 1 hit.
Pfam	PF00501. AMP-binding. 1 hit. PF11930. DUF3448. 1 hit. [Graphical view]
TIGRFAMs	TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITE	PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A5V439_SPHWW

Accession

Primary (citable) accession number: A5V439

Entry history

Integrated into UniProtKB/TrEMBL:	July 10, 2007
Last sequence update:	July 10, 2007
Last modified:	December 14, 2011
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)