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A5V412

- UPPP_SPHWW

UniProt

A5V412 - UPPP_SPHWW

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Sphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (10 Jul 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciSWIT392499:GHZK-672-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance proteinUniRule annotation
    Undecaprenyl pyrophosphate phosphataseUniRule annotation
    Gene namesi
    Name:uppPUniRule annotation
    Ordered Locus Names:Swit_0660
    OrganismiSphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)
    Taxonomic identifieri392499 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeSphingomonas
    ProteomesiUP000001989: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 266266Undecaprenyl-diphosphatasePRO_1000062816Add
    BLAST

    Proteomic databases

    PRIDEiA5V412.

    Interactioni

    Protein-protein interaction databases

    STRINGi392499.Swit_0660.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei3 – 2321HelicalUniRule annotationAdd
    BLAST
    Transmembranei41 – 6121HelicalUniRule annotationAdd
    BLAST
    Transmembranei86 – 10621HelicalUniRule annotationAdd
    BLAST
    Transmembranei108 – 12821HelicalUniRule annotationAdd
    BLAST
    Transmembranei149 – 17123HelicalUniRule annotationAdd
    BLAST
    Transmembranei184 – 20421HelicalUniRule annotationAdd
    BLAST
    Transmembranei220 – 24021HelicalUniRule annotationAdd
    BLAST
    Transmembranei245 – 26521HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218356.
    KOiK06153.
    OMAiFNDAHAK.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A5V412-1 [UniParc]FASTAAdd to Basket

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    MEMSLLSIVL LGIVEGVTEF LPVSSTGHLI LAGEVMKVPQ GTETFDIVIQ    50
    LGAILAVVVL YRERFAAVLA GLGRRDPAAI RFTRNVLVGF LPSAVIGAVA 100
    YGAIKAMLNT PIIVAVALIL GGIAILVIER LVRSPTCDSV EGMSLRTSFG 150
    VGLVQCLSMI PGVSRSGATI MGALTLGVER RTAAEYSFFL AIPTMLGATT 200
    LALWKARHEL GDAQATAIAI GFVVSFIVAM LVIRWFLGVV TRHGFAPFAW 250
    YRIIAGTAAL IWLLAR 266
    Length:266
    Mass (Da):28,222
    Last modified:July 10, 2007 - v1
    Checksum:i6E33836EF2FB0903
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000699 Genomic DNA. Translation: ABQ67028.1.
    RefSeqiYP_001261166.1. NC_009511.1.

    Genome annotation databases

    EnsemblBacteriaiABQ67028; ABQ67028; Swit_0660.
    GeneIDi5196654.
    KEGGiswi:Swit_0660.
    PATRICi23680326. VBISphWit55028_1129.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000699 Genomic DNA. Translation: ABQ67028.1 .
    RefSeqi YP_001261166.1. NC_009511.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 392499.Swit_0660.

    Proteomic databases

    PRIDEi A5V412.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ67028 ; ABQ67028 ; Swit_0660 .
    GeneIDi 5196654.
    KEGGi swi:Swit_0660.
    PATRICi 23680326. VBISphWit55028_1129.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218356.
    KOi K06153.
    OMAi FNDAHAK.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci SWIT392499:GHZK-672-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RW1 / DSM 6014 / JCM 10273.

    Entry informationi

    Entry nameiUPPP_SPHWW
    AccessioniPrimary (citable) accession number: A5V412
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3