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Protein

S-adenosylmethionine:tRNA ribosyltransferase-isomerase

Gene

queA

Organism
Sphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + 7-aminomethyl-7-carbaguanosine(34) in tRNA = L-methionine + adenine + epoxyqueuosine(34) in tRNA.UniRule annotation

Pathwayi: tRNA-queuosine biosynthesis

This protein is involved in the pathway tRNA-queuosine biosynthesis, which is part of tRNA modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tRNA-queuosine biosynthesis and in tRNA modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processQueuosine biosynthesis
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00392

Names & Taxonomyi

Protein namesi
Recommended name:
S-adenosylmethionine:tRNA ribosyltransferase-isomeraseUniRule annotation (EC:2.4.99.17UniRule annotation)
Alternative name(s):
Queuosine biosynthesis protein QueAUniRule annotation
Gene namesi
Name:queAUniRule annotation
Ordered Locus Names:Swit_0025
OrganismiSphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)
Taxonomic identifieri392499 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeSphingomonas
Proteomesi
  • UP000001989 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000152841 – 344S-adenosylmethionine:tRNA ribosyltransferase-isomeraseAdd BLAST344

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi392499.Swit_0025

Structurei

3D structure databases

ProteinModelPortaliA5V282
SMRiA5V282
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the QueA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E2N Bacteria
COG0809 LUCA
HOGENOMiHOG000004401
KOiK07568
OMAiYSYGDGM
OrthoDBiPOG091H00ZG

Family and domain databases

HAMAPiMF_00113 QueA, 1 hit
InterProiView protein in InterPro
IPR003699 QueA
IPR036100 QueA_sf
PANTHERiPTHR30307 PTHR30307, 1 hit
PfamiView protein in Pfam
PF02547 Queuosine_synth, 1 hit
SUPFAMiSSF111337 SSF111337, 1 hit
TIGRFAMsiTIGR00113 queA, 1 hit

Sequencei

Sequence statusi: Complete.

A5V282-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVDLFDFDL PPENIALRPA SPRDSARMLL VEGSEGALAD RHVSDLPGLL
60 70 80 90 100
RVGDCLVFND TRVIPAQLEG RRGEARIGAT LHKREGLRQW RAFVRNAKRV
110 120 130 140 150
RTGDRIDFGA GVSAIAAERG EDGSILLDFE GDEPVELLLE RAGTMPLPPY
160 170 180 190 200
IAGKRPTDDR DRDDYQTMFA REKGAVAAPT AALHFTPRLM EALAAAGIAS
210 220 230 240 250
ETLTLHVGAG TFLPVKADDT DDHRMHAEWG RIDAATADHL NAIRAAGGRV
260 270 280 290 300
IAVGTTSLRL LESATGEDGV IRPFDGDTAI FITPGYRFRA IDGLMTNFHL
310 320 330 340
PKSTLFMLVS ALMGRDRMQA AYAHAIAEGY RFYSYGDSSL LLPG
Length:344
Mass (Da):37,438
Last modified:July 10, 2007 - v1
Checksum:iE2C31275CF0193C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000699 Genomic DNA Translation: ABQ66398.1
RefSeqiWP_011950878.1, NC_009511.1

Genome annotation databases

EnsemblBacteriaiABQ66398; ABQ66398; Swit_0025
KEGGiswi:Swit_0025

Similar proteinsi

Entry informationi

Entry nameiQUEA_SPHWW
AccessioniPrimary (citable) accession number: A5V282
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 10, 2007
Last modified: April 25, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health