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A5V270

- A5V270_SPHWW

UniProt

A5V270 - A5V270_SPHWW

Protein

Alanine racemase

Gene

Swit_0013

Organism
Sphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (10 Jul 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei37 – 371Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei131 – 1311SubstrateUniRule annotation
    Active sitei248 – 2481Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei296 – 2961Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciSWIT392499:GHZK-13-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Ordered Locus Names:Swit_0013Imported
    OrganismiSphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)Imported
    Taxonomic identifieri392499 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeSphingomonas
    ProteomesiUP000001989: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei37 – 371N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi392499.Swit_0013.

    Structurei

    3D structure databases

    ProteinModelPortaliA5V270.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0787.
    HOGENOMiHOG000031445.
    KOiK01775.
    OMAiTHLAWAD.
    OrthoDBiEOG6PP9NJ.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5V270-1 [UniParc]FASTAAdd to Basket

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    MTQEFLPLRL DLDPQALVAN WRWLGERAAA PAGAAIKADA YGLGAVEVSR    50
    RLADAGCRDF FVATWAETEA LGSLPFGAGL SVLHGLREED LAAALASRAR 100
    PVLNSPAMVA RWKAAAPGRP CDVMIDTGMN RLGLTVEEAC SGLLDGLEID 150
    LLLSHLACAD EPDSPMNERQ RARFVDLRGR VAAKRHSLAN SAGACLGPAY 200
    GFDLIRPGIA LYGGIPRPEA RGHIVRVVRI EAQVLQVRDV PAGDTIGYGA 250
    TFTAERPMRV AILNLGYADG YLRAFAGNGA ALVNGRRCPL AGRVSMDLIA 300
    VDLTGADAAE GDWLEIDYAL ESAADRTGLS QYELLTGLGS RYQRRWKE 348
    Length:348
    Mass (Da):37,236
    Last modified:July 10, 2007 - v1
    Checksum:iF8AF1C96FC5E9534
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000699 Genomic DNA. Translation: ABQ66386.1.
    RefSeqiYP_001260524.1. NC_009511.1.

    Genome annotation databases

    EnsemblBacteriaiABQ66386; ABQ66386; Swit_0013.
    GeneIDi5200617.
    KEGGiswi:Swit_0013.
    PATRICi23678976. VBISphWit55028_0464.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000699 Genomic DNA. Translation: ABQ66386.1 .
    RefSeqi YP_001260524.1. NC_009511.1.

    3D structure databases

    ProteinModelPortali A5V270.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 392499.Swit_0013.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ66386 ; ABQ66386 ; Swit_0013 .
    GeneIDi 5200617.
    KEGGi swi:Swit_0013.
    PATRICi 23678976. VBISphWit55028_0464.

    Phylogenomic databases

    eggNOGi COG0787.
    HOGENOMi HOG000031445.
    KOi K01775.
    OMAi THLAWAD.
    OrthoDBi EOG6PP9NJ.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci SWIT392499:GHZK-13-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RW1 / DSM 6014 / JCM 10273Imported.

    Entry informationi

    Entry nameiA5V270_SPHWW
    AccessioniPrimary (citable) accession number: A5V270
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 10, 2007
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3