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Protein

Histidine--tRNA ligase

Gene

hisS

Organism
Roseiflexus sp. (strain RS-1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetaseUniRule annotationSAAS annotation, Ligase

Keywords - Biological processi

Protein biosynthesisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciRSP357808:GH5Z-4628-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine--tRNA ligaseUniRule annotationSAAS annotation (EC:6.1.1.21UniRule annotationSAAS annotation)
Alternative name(s):
Histidyl-tRNA synthetaseUniRule annotation
Gene namesi
Name:hisSUniRule annotation
Ordered Locus Names:RoseRS_4574Imported
OrganismiRoseiflexus sp. (strain RS-1)Imported
Taxonomic identifieri357808 [NCBI]
Taxonomic lineageiBacteriaChloroflexiChloroflexiaChloroflexalesRoseiflexineaeRoseiflexaceaeRoseiflexus
ProteomesiUP000006554 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi357808.RoseRS_4574.

Structurei

3D structure databases

ProteinModelPortaliA5V202.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-II aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0124.
HOGENOMiHOG000018071.
KOiK01892.
OMAiKDYNENL.
OrthoDBiEOG6BPDH4.

Family and domain databases

Gene3Di3.40.50.800. 1 hit.
HAMAPiMF_00125. HisZ.
MF_00127. His_tRNA_synth.
InterProiIPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR015807. His-tRNA-ligase.
IPR004516. HisRS/HisZ.
IPR004517. HisZ.
[Graphical view]
PANTHERiPTHR11476. PTHR11476. 1 hit.
PfamiPF03129. HGTP_anticodon. 1 hit.
[Graphical view]
PIRSFiPIRSF001549. His-tRNA_synth. 1 hit.
SUPFAMiSSF52954. SSF52954. 1 hit.
TIGRFAMsiTIGR00442. hisS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5V202-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNRVQNIRG MRDHLPSAMI LRQYIIDTLT SVFERYGFEP LQTPVVEYAE
60 70 80 90 100
TLDGKIGDDE KLIYRFEDHG GRKVALRYDQ TVPLARVVAQ YQGQLLFPWR
110 120 130 140 150
RYAIGQSYRG ERPGRGRYRE LWQADIDIVG SASPLADAEI LAVLTDALTA
160 170 180 190 200
LGFTGFTTLI SHRQILGGIA RVSGLDDAAA GDVYRAIDKL DKIGIDGVRN
210 220 230 240 250
DLLQSGVSTA AAERILALID LQGDADEVLN ALAQQLQGDE RALQAIDNVR
260 270 280 290 300
AIIGYARAMG VPEERIVIAP RLARGLSYYT GAVFESIVQN PPMGSLLGGG
310 320 330 340 350
RYDELIGMFA GRSIPTVGLA FGIERLHDVM EELGMGPASR TIATAFVTLF
360 370 380 390 400
NPDMAAESLR LAQELRRAGL LVETALDPSE KLGKQLQYAD RRGIPYALVI
410 420 430 440 450
GPDELARGEV VVKDLRSGAQ QSVVRSAVAS QLRSAADARR TPRTAYDQGG

THERQTS
Length:457
Mass (Da):49,924
Last modified:July 10, 2007 - v1
Checksum:iDEC88B1F10644C4D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000686 Genomic DNA. Translation: ABQ92905.1.
RefSeqiWP_011959242.1. NC_009523.1.

Genome annotation databases

EnsemblBacteriaiABQ92905; ABQ92905; RoseRS_4574.
KEGGirrs:RoseRS_4574.
PATRICi23358068. VBIRosSp109359_5060.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000686 Genomic DNA. Translation: ABQ92905.1.
RefSeqiWP_011959242.1. NC_009523.1.

3D structure databases

ProteinModelPortaliA5V202.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi357808.RoseRS_4574.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABQ92905; ABQ92905; RoseRS_4574.
KEGGirrs:RoseRS_4574.
PATRICi23358068. VBIRosSp109359_5060.

Phylogenomic databases

eggNOGiCOG0124.
HOGENOMiHOG000018071.
KOiK01892.
OMAiKDYNENL.
OrthoDBiEOG6BPDH4.

Enzyme and pathway databases

BioCyciRSP357808:GH5Z-4628-MONOMER.

Family and domain databases

Gene3Di3.40.50.800. 1 hit.
HAMAPiMF_00125. HisZ.
MF_00127. His_tRNA_synth.
InterProiIPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR015807. His-tRNA-ligase.
IPR004516. HisRS/HisZ.
IPR004517. HisZ.
[Graphical view]
PANTHERiPTHR11476. PTHR11476. 1 hit.
PfamiPF03129. HGTP_anticodon. 1 hit.
[Graphical view]
PIRSFiPIRSF001549. His-tRNA_synth. 1 hit.
SUPFAMiSSF52954. SSF52954. 1 hit.
TIGRFAMsiTIGR00442. hisS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RS-1Imported.

Entry informationi

Entry nameiA5V202_ROSS1
AccessioniPrimary (citable) accession number: A5V202
Entry historyi
Integrated into UniProtKB/TrEMBL: July 10, 2007
Last sequence update: July 10, 2007
Last modified: July 22, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.