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A5V1W3

- SYL_ROSS1

UniProt

A5V1W3 - SYL_ROSS1

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Protein

Leucine--tRNA ligase

Gene
leuS, RoseRS_4535
Organism
Roseiflexus sp. (strain RS-1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei666 – 6661ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRSP357808:GH5Z-4588-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:RoseRS_4535
OrganismiRoseiflexus sp. (strain RS-1)
Taxonomic identifieri357808 [NCBI]
Taxonomic lineageiBacteriaChloroflexiChloroflexiaChloroflexalesRoseiflexineaeRoseiflexaceaeRoseiflexus
ProteomesiUP000006554: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 904904Leucine--tRNA ligaseUniRule annotationPRO_0000334807Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi357808.RoseRS_4535.

Structurei

3D structure databases

ProteinModelPortaliA5V1W3.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi49 – 5911"HIGH" regionUniRule annotationAdd
BLAST
Motifi663 – 6675"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5V1W3-1 [UniParc]FASTAAdd to Basket

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MSETGAKRRM DRFDPSIEPK WREFWAREGI FKAGRRAGAP RRYILEMFPY    50
PSGDLHIGHL KNYVIGDALT RYYVIRGYDV LHPFGWDAFG LPAENAAIKY 100
GRHPREWTYS NIAESKKSLE IAGIMYDWSR EVTTCNPDYY RWNQWLFLLL 150
YRKGLAYRAK ATVNWDPVDQ TVLANEQVDA EGRSWRSGAK VEKRELEQWF 200
FRITAYAERL LNDLDKLDRW PENVKTMQRN WIGRSEGAEV TFLALPPGAD 250
LYAPPPPDAE PLVVFTTRPD TLWGATFMVL APEHPLAPKL TAPERRAEVE 300
AYIARARMES EIERTSATRE KSGVFLGSYA INPVNDERIP IWIADYVLMG 350
YGTGAIMAVP AHDQRDFEFA RQFGLPVRVV VQPPGETLDG DTMTEAWPGD 400
GVMVNSGPIN GIPVGKGEGQ SVKAAIAWLE AQGKGKGTVT YRLRDWLISR 450
QRYWGTPIPM LHLPDGTIKP VPEDQLPVLL PEVQDYLPKG KSPLAAAEHW 500
VNTIDPETGQ PARRDTDTMD TFVDSSWYFL RFCDAQNDRE IFSREAARQW 550
MPVDQYIGGV EHAILHLLYA RFITKVLYDE GLVPEDEPFK ALFTQGMVQR 600
RVRTPLDIVA PGMVRFPEEL RRKLELPAEA QTVDQARALL KERGYTLEEE 650
SDGGLTAVSG PVTMSKSAGN GIPVGPFVRQ YGSDVARIVV LFAAPPENSM 700
EWTDEGVAGA QRFLNRIVAL FGPDRDEIAA MVRSGNGAAP EGEDRALYRK 750
LHETIRKVTL DTEQFRFNTA IAALMELLNE ASRYRAEVGR VTPVFAQTAA 800
TFARLLSPFA PHLAEEVHSW CGGTGSVYDA GWPEWDESAL VLDEVEIVLQ 850
VNGKLRGKIM APAGADEEQL REWALTNPRV LSFVGDKTVR KVIVVPGKLV 900
NVVV 904
Length:904
Mass (Da):101,693
Last modified:July 10, 2007 - v1
Checksum:iD820E78E06A50E46
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000686 Genomic DNA. Translation: ABQ92866.1.
RefSeqiWP_011959203.1. NC_009523.1.
YP_001278816.1. NC_009523.1.

Genome annotation databases

EnsemblBacteriaiABQ92866; ABQ92866; RoseRS_4535.
GeneIDi5211520.
KEGGirrs:RoseRS_4535.
PATRICi23357984. VBIRosSp109359_5019.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000686 Genomic DNA. Translation: ABQ92866.1 .
RefSeqi WP_011959203.1. NC_009523.1.
YP_001278816.1. NC_009523.1.

3D structure databases

ProteinModelPortali A5V1W3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 357808.RoseRS_4535.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ92866 ; ABQ92866 ; RoseRS_4535 .
GeneIDi 5211520.
KEGGi rrs:RoseRS_4535.
PATRICi 23357984. VBIRosSp109359_5019.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci RSP357808:GH5Z-4588-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RS-1.

Entry informationi

Entry nameiSYL_ROSS1
AccessioniPrimary (citable) accession number: A5V1W3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 10, 2007
Last modified: September 3, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi