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A5V1W3 (SYL_ROSS1) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:RoseRS_4535
OrganismRoseiflexus sp. (strain RS-1) [Complete proteome] [HAMAP]
Taxonomic identifier357808 [NCBI]
Taxonomic lineageBacteriaChloroflexiChloroflexalesChloroflexaceaeRoseiflexus

Protein attributes

Sequence length904 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 904904Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_0000334807

Regions

Motif49 – 5911"HIGH" region HAMAP-Rule MF_00049
Motif663 – 6675"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site6661ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A5V1W3 [UniParc].

Last modified July 10, 2007. Version 1.
Checksum: D820E78E06A50E46

FASTA904101,693
        10         20         30         40         50         60 
MSETGAKRRM DRFDPSIEPK WREFWAREGI FKAGRRAGAP RRYILEMFPY PSGDLHIGHL 

        70         80         90        100        110        120 
KNYVIGDALT RYYVIRGYDV LHPFGWDAFG LPAENAAIKY GRHPREWTYS NIAESKKSLE 

       130        140        150        160        170        180 
IAGIMYDWSR EVTTCNPDYY RWNQWLFLLL YRKGLAYRAK ATVNWDPVDQ TVLANEQVDA 

       190        200        210        220        230        240 
EGRSWRSGAK VEKRELEQWF FRITAYAERL LNDLDKLDRW PENVKTMQRN WIGRSEGAEV 

       250        260        270        280        290        300 
TFLALPPGAD LYAPPPPDAE PLVVFTTRPD TLWGATFMVL APEHPLAPKL TAPERRAEVE 

       310        320        330        340        350        360 
AYIARARMES EIERTSATRE KSGVFLGSYA INPVNDERIP IWIADYVLMG YGTGAIMAVP 

       370        380        390        400        410        420 
AHDQRDFEFA RQFGLPVRVV VQPPGETLDG DTMTEAWPGD GVMVNSGPIN GIPVGKGEGQ 

       430        440        450        460        470        480 
SVKAAIAWLE AQGKGKGTVT YRLRDWLISR QRYWGTPIPM LHLPDGTIKP VPEDQLPVLL 

       490        500        510        520        530        540 
PEVQDYLPKG KSPLAAAEHW VNTIDPETGQ PARRDTDTMD TFVDSSWYFL RFCDAQNDRE 

       550        560        570        580        590        600 
IFSREAARQW MPVDQYIGGV EHAILHLLYA RFITKVLYDE GLVPEDEPFK ALFTQGMVQR 

       610        620        630        640        650        660 
RVRTPLDIVA PGMVRFPEEL RRKLELPAEA QTVDQARALL KERGYTLEEE SDGGLTAVSG 

       670        680        690        700        710        720 
PVTMSKSAGN GIPVGPFVRQ YGSDVARIVV LFAAPPENSM EWTDEGVAGA QRFLNRIVAL 

       730        740        750        760        770        780 
FGPDRDEIAA MVRSGNGAAP EGEDRALYRK LHETIRKVTL DTEQFRFNTA IAALMELLNE 

       790        800        810        820        830        840 
ASRYRAEVGR VTPVFAQTAA TFARLLSPFA PHLAEEVHSW CGGTGSVYDA GWPEWDESAL 

       850        860        870        880        890        900 
VLDEVEIVLQ VNGKLRGKIM APAGADEEQL REWALTNPRV LSFVGDKTVR KVIVVPGKLV 


NVVV 

« Hide

References

[1]"Complete sequence of Roseiflexus sp. RS-1."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Mikhailova N., Bryant D.A., Richardson P.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RS-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000686 Genomic DNA. Translation: ABQ92866.1.
RefSeqYP_001278816.1. NC_009523.1.

3D structure databases

ProteinModelPortalA5V1W3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING357808.RoseRS_4535.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABQ92866; ABQ92866; RoseRS_4535.
GeneID5211520.
KEGGrrs:RoseRS_4535.
PATRIC23357984. VBIRosSp109359_5019.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200747.
KOK01869.
OMAHISHELW.
OrthoDBEOG63Z74X.

Enzyme and pathway databases

BioCycRSP357808:GH5Z-4588-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_ROSS1
AccessionPrimary (citable) accession number: A5V1W3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 10, 2007
Last modified: May 14, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries