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A5UZV5

- KITH_ROSS1

UniProt

A5UZV5 - KITH_ROSS1

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Protein

Thymidine kinase

Gene
tdk, RoseRS_3804
Organism
Roseiflexus sp. (strain RS-1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei88 – 881Proton acceptor Reviewed prediction
Metal bindingi147 – 1471Zinc By similarity
Metal bindingi150 – 1501Zinc By similarity
Metal bindingi185 – 1851Zinc By similarity
Metal bindingi188 – 1881Zinc By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi14 – 218ATP By similarity
Nucleotide bindingi87 – 904ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

DNA synthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciRSP357808:GH5Z-3853-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinase (EC:2.7.1.21)
Gene namesi
Name:tdk
Ordered Locus Names:RoseRS_3804
OrganismiRoseiflexus sp. (strain RS-1)
Taxonomic identifieri357808 [NCBI]
Taxonomic lineageiBacteriaChloroflexiChloroflexiaChloroflexalesRoseiflexineaeRoseiflexaceaeRoseiflexus
ProteomesiUP000006554: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 193193Thymidine kinaseUniRule annotationPRO_1000076240Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi357808.RoseRS_3804.

Structurei

3D structure databases

ProteinModelPortaliA5UZV5.

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.

Phylogenomic databases

eggNOGiCOG1435.
HOGENOMiHOG000076390.
KOiK00857.
OMAiQAICLSC.
OrthoDBiEOG69D3J2.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5UZV5-1 [UniParc]FASTAAdd to Basket

« Hide

MTRLLGGRIE VICGCMFSGK TEELIRRLNH VRLARQRLIA FTPRRDTRYR    50
LGSLVSHNGL SVEARVIDSI RDIPAYLDSD VDVVAVDELH LLDDPPDAAR 100
EVCQQLADRG LRVIVAGLDQ DFRAQPFPAM AQLMAVAEQV DKLYAICVRC 150
GAYATRSQRL IDGKPAPADA PTIVVGGQEL YEARCRACYE PAQ 193
Length:193
Mass (Da):21,407
Last modified:July 10, 2007 - v1
Checksum:i653AFC65A62C9456
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000686 Genomic DNA. Translation: ABQ92158.1.
RefSeqiWP_011958499.1. NC_009523.1.
YP_001278108.1. NC_009523.1.

Genome annotation databases

EnsemblBacteriaiABQ92158; ABQ92158; RoseRS_3804.
GeneIDi5210786.
KEGGirrs:RoseRS_3804.
PATRICi23356379. VBIRosSp109359_4222.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000686 Genomic DNA. Translation: ABQ92158.1 .
RefSeqi WP_011958499.1. NC_009523.1.
YP_001278108.1. NC_009523.1.

3D structure databases

ProteinModelPortali A5UZV5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 357808.RoseRS_3804.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ92158 ; ABQ92158 ; RoseRS_3804 .
GeneIDi 5210786.
KEGGi rrs:RoseRS_3804.
PATRICi 23356379. VBIRosSp109359_4222.

Phylogenomic databases

eggNOGi COG1435.
HOGENOMi HOG000076390.
KOi K00857.
OMAi QAICLSC.
OrthoDBi EOG69D3J2.

Enzyme and pathway databases

BioCyci RSP357808:GH5Z-3853-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RS-1.

Entry informationi

Entry nameiKITH_ROSS1
AccessioniPrimary (citable) accession number: A5UZV5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 10, 2007
Last modified: September 3, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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