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Protein

N-(5'-phosphoribosyl)anthranilate isomerase

Gene

trpF

Organism
Roseiflexus sp. (strain RS-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.UniRule annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Anthranilate synthase component 1 (trpE)
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (trpF)
  4. Indole-3-glycerol phosphate synthase (trpC)
  5. Tryptophan synthase beta chain (trpB), Tryptophan synthase alpha chain (trpA), Tryptophan synthase beta chain (trpB)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

BioCyciRSP357808:G1G8U-3601-MONOMER
UniPathwayiUPA00035; UER00042

Names & Taxonomyi

Protein namesi
Recommended name:
N-(5'-phosphoribosyl)anthranilate isomeraseUniRule annotation (EC:5.3.1.24UniRule annotation)
Short name:
PRAIUniRule annotation
Gene namesi
Name:trpFUniRule annotation
Ordered Locus Names:RoseRS_3444
OrganismiRoseiflexus sp. (strain RS-1)
Taxonomic identifieri357808 [NCBI]
Taxonomic lineageiBacteriaChloroflexiChloroflexiaChloroflexalesRoseiflexineaeRoseiflexaceaeRoseiflexus
Proteomesi
  • UP000006554 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000186381 – 213N-(5'-phosphoribosyl)anthranilate isomeraseAdd BLAST213

Proteomic databases

PRIDEiA5UYU9

Interactioni

Protein-protein interaction databases

STRINGi357808.RoseRS_3444

Structurei

3D structure databases

ProteinModelPortaliA5UYU9
SMRiA5UYU9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpF family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108ZGB Bacteria
COG0135 LUCA
HOGENOMiHOG000161598
KOiK01817
OMAiFYAKSPR
OrthoDBiPOG091H01PA

Family and domain databases

CDDicd00405 PRAI, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00135 PRAI, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR001240 PRAI
IPR011060 RibuloseP-bd_barrel
PfamiView protein in Pfam
PF00697 PRAI, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit

Sequencei

Sequence statusi: Complete.

A5UYU9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MINVKICGVR TRDHALTAVD AGADMIGLVF APSRRRINPD DAAVIAAAVR
60 70 80 90 100
TAADDRRRQV SLIGVFVNDD VTRIRKIATL CGLDGIQLSG DEPVAYAADL
110 120 130 140 150
APFLVIKAIR FDNSAHERDW LSEDQAHVRL LVDAHVPGSY GGAGVVADWD
160 170 180 190 200
RAADLARRRP LLLAGGLTPA NVAEAIRYVR PWGVDVSSGV ESNGVKDHQK
210
IRAFVAAARA AAQ
Length:213
Mass (Da):22,792
Last modified:July 10, 2007 - v1
Checksum:i76DC7838A880E5AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000686 Genomic DNA Translation: ABQ91802.1
RefSeqiWP_011958144.1, NC_009523.1

Genome annotation databases

EnsemblBacteriaiABQ91802; ABQ91802; RoseRS_3444
KEGGirrs:RoseRS_3444

Similar proteinsi

Entry informationi

Entry nameiTRPF_ROSS1
AccessioniPrimary (citable) accession number: A5UYU9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 10, 2007
Last modified: May 23, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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