A5UVV6 (GMHA_ROSS1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoheptose isomerase
EC=5.3.1.28

Alternative name(s):
Sedoheptulose 7-phosphate isomerase

Gene names

Name:	gmhA
Ordered Locus Names:	RoseRS_2381

Organism

Roseiflexus sp. (strain RS-1) [Complete proteome] [HAMAP]

Taxonomic identifier

357808 [NCBI]

Taxonomic lineage

Bacteria › Chloroflexi › Chloroflexales › Chloroflexaceae › Roseiflexus

Protein attributes

Sequence length	197 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate By similarity. HAMAP MF_00067
Catalytic activity	D-sedoheptulose 7-phosphate = D-glycero-D-manno-heptose 7-phosphate. HAMAP MF_00067
Cofactor	Binds 1 zinc ion per subunit By similarity. HAMAP MF_00067
Pathway	Carbohydrate biosynthesis; D-glycero-D-manno-heptose 7-phosphate biosynthesis; D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate from sedoheptulose 7-phosphate: step 1/1. HAMAP MF_00067
Subcellular location	Cytoplasm By similarity HAMAP MF_00067.
Miscellaneous	The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate By similarity. HAMAP MF_00067
Sequence similarities	Belongs to the SIS family. GmhA subfamily. Contains 1 SIS domain.

Ontologies

Keywords
Biological process	Carbohydrate metabolism
Cellular component	Cytoplasm
Ligand	Metal-binding Zinc
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipopolysaccharide core region biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	D-sedoheptulose 7-phosphate isomerase activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW sugar binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 197	197	Phosphoheptose isomerase HAMAP MF_00067		PRO_1000075102
Regions
	Domain	41 – 197	157	SIS
	Region	56 – 58	3	Substrate binding By similarity
	Region	98 – 99	2	Substrate binding By similarity
	Region	124 – 126	3	Substrate binding By similarity
Sites
	Metal binding	65	1	Zinc By similarity
	Metal binding	69	1	Zinc By similarity
	Metal binding	176	1	Zinc By similarity
	Metal binding	184	1	Zinc By similarity
	Binding site	69	1	Substrate By similarity
	Binding site	129	1	Substrate By similarity
	Binding site	176	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	A5UVV6 [UniParc]. Last modified July 10, 2007. Version 1. Checksum: CC5B6F0D97801208	FASTA	197	21,168
	10 20 30 40 50 60 MNSPSDSFTR WVIDEIEASI DVKRRTIETQ APMIVAIAER VVETFRRGGK LLLCGNGGSA 70 80 90 100 110 120 ADAQHIAAEF VSRFRRERHG LPAIALTTDT SILTAISNDY GYERVFARQV EALGRPGDMV 130 140 150 160 170 180 IGISTSGISA SVIAAMRAAR NGGMATVGFT GASGGTLVDH VDLCLCVPSH NTARIQEVHI 190 TVAHVVCEIV ERTLFEE

References

[1]

"Complete sequence of Roseiflexus sp. RS-1." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Mikhailova N., Bryant D.A., Richardson P. Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RS-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000686 Genomic DNA. Translation: ABQ90759.1.
RefSeq	YP_001276709.1. NC_009523.1.
3D structure databases
ProteinModelPortal	A5UVV6.
ModBase	Search...
Protein-protein interaction databases
STRING	A5UVV6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5209350.
GenomeReviews	Gene locus RoseRS_2381 in contig CP000686_GR.
KEGG	rrs:RoseRS_2381.
PATRIC	23353170. VBIRosSp109359_2631.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0279.
HOGENOM	HBG671955.
OMA	HITIIHI.
ProtClustDB	PRK13937.
Enzyme and pathway databases
BioCyc	RSP357808:ROSERS_2381-MONOMER.
Family and domain databases
HAMAP	MF_00067. GmhA. [Tree]
InterPro	IPR004515. Phosphoheptose_Isoase_subgr. IPR020620. Phosphoheptose_isomerase. IPR001347. SIS. [Graphical view]
KO	K03271.
Pfam	PF01380. SIS. 1 hit. [Graphical view]
TIGRFAMs	TIGR00441. GmhA. 1 hit.
PROSITE	PS51464. SIS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GMHA_ROSS1

Accession

Primary (citable) accession number: A5UVV6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	July 10, 2007
Last modified:	January 25, 2012
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program