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Protein

Demethylmenaquinone methyltransferase

Gene

menG

Organism
Roseiflexus sp. (strain RS-1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).UniRule annotation

Catalytic activityi

A demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + S-adenosyl-L-homocysteine.UniRule annotation

Pathwayi: menaquinone biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes menaquinol from 1,4-dihydroxy-2-naphthoate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. 1,4-dihydroxy-2-naphthoate octaprenyltransferase (menA)
  2. Demethylmenaquinone methyltransferase (menG)
This subpathway is part of the pathway menaquinone biosynthesis, which is itself part of Quinol/quinone metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes menaquinol from 1,4-dihydroxy-2-naphthoate, the pathway menaquinone biosynthesis and in Quinol/quinone metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei65S-adenosyl-L-methionineUniRule annotation1
Binding sitei85S-adenosyl-L-methionineUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Menaquinone biosynthesis

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00079; UER00169.

Names & Taxonomyi

Protein namesi
Recommended name:
Demethylmenaquinone methyltransferaseUniRule annotation (EC:2.1.1.163UniRule annotation)
Gene namesi
Name:menGUniRule annotation
Ordered Locus Names:RoseRS_2185
OrganismiRoseiflexus sp. (strain RS-1)
Taxonomic identifieri357808 [NCBI]
Taxonomic lineageiBacteriaChloroflexiChloroflexiaChloroflexalesRoseiflexineaeRoseiflexaceaeRoseiflexus
Proteomesi
  • UP000006554 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001878011 – 238Demethylmenaquinone methyltransferaseAdd BLAST238

Interactioni

Protein-protein interaction databases

STRINGi357808.RoseRS_2185.

Structurei

3D structure databases

ProteinModelPortaliA5UVB2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni109 – 110S-adenosyl-L-methionine bindingUniRule annotation2

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QNM. Bacteria.
COG2226. LUCA.
HOGENOMiHOG000249464.
KOiK03183.
OMAiQKSALNC.
OrthoDBiPOG091H01LK.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01813. MenG_UbiE_methyltr. 1 hit.
InterProiIPR029063. SAM-dependent_MTases.
IPR004033. UbiE/COQ5_MeTrFase.
[Graphical view]
PfamiPF01209. Ubie_methyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR01934. MenG_MenH_UbiE. 1 hit.
PROSITEiPS51608. SAM_MT_UBIE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5UVB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTTVLPPPD KKAEYVERMF SRIAPGYDTM NGIITLGLDR EWRATTVALA
60 70 80 90 100
APPSCGRALD IGTGTGDFLV ELTAWMPDGL AVGVDFTVPM MRAGLPKIRD
110 120 130 140 150
RRAVFVAGDA LKLPFADESF DAITTGFTLR NVTDIAAAFR EMWRVARVGA
160 170 180 190 200
TVACLEVARP RHPLLRAGHW FYFQRIVPLM ARALGADPEA YTYLPQSARI
210 220 230
FPPPEELAQI MRAAGWSDVT YRLVGLGAAA IHTGIKRG
Length:238
Mass (Da):26,005
Last modified:July 10, 2007 - v1
Checksum:i1703D48966766286
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000686 Genomic DNA. Translation: ABQ90565.1.
RefSeqiWP_011956911.1. NC_009523.1.

Genome annotation databases

EnsemblBacteriaiABQ90565; ABQ90565; RoseRS_2185.
KEGGirrs:RoseRS_2185.
PATRICi23352716. VBIRosSp109359_2409.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000686 Genomic DNA. Translation: ABQ90565.1.
RefSeqiWP_011956911.1. NC_009523.1.

3D structure databases

ProteinModelPortaliA5UVB2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi357808.RoseRS_2185.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABQ90565; ABQ90565; RoseRS_2185.
KEGGirrs:RoseRS_2185.
PATRICi23352716. VBIRosSp109359_2409.

Phylogenomic databases

eggNOGiENOG4107QNM. Bacteria.
COG2226. LUCA.
HOGENOMiHOG000249464.
KOiK03183.
OMAiQKSALNC.
OrthoDBiPOG091H01LK.

Enzyme and pathway databases

UniPathwayiUPA00079; UER00169.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01813. MenG_UbiE_methyltr. 1 hit.
InterProiIPR029063. SAM-dependent_MTases.
IPR004033. UbiE/COQ5_MeTrFase.
[Graphical view]
PfamiPF01209. Ubie_methyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR01934. MenG_MenH_UbiE. 1 hit.
PROSITEiPS51608. SAM_MT_UBIE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMENG_ROSS1
AccessioniPrimary (citable) accession number: A5UVB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: July 10, 2007
Last modified: November 2, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.