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A5UUL2

- THIM_ROSS1

UniProt

A5UUL2 - THIM_ROSS1

Protein

Hydroxyethylthiazole kinase

Gene

thiM

Organism
Roseiflexus sp. (strain RS-1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (10 Jul 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).UniRule annotation

    Catalytic activityi

    ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei47 – 471Substrate; via amide nitrogenUniRule annotation
    Binding sitei123 – 1231ATPUniRule annotation
    Binding sitei169 – 1691ATPUniRule annotation
    Binding sitei196 – 1961Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. hydroxyethylthiazole kinase activity Source: UniProtKB-HAMAP
    3. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. thiamine biosynthetic process Source: UniProtKB-KW
    2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Thiamine biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRSP357808:GH5Z-1954-MONOMER.
    UniPathwayiUPA00060; UER00139.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hydroxyethylthiazole kinaseUniRule annotation (EC:2.7.1.50UniRule annotation)
    Alternative name(s):
    4-methyl-5-beta-hydroxyethylthiazole kinaseUniRule annotation
    Short name:
    TH kinaseUniRule annotation
    Short name:
    Thz kinaseUniRule annotation
    Gene namesi
    Name:thiMUniRule annotation
    Ordered Locus Names:RoseRS_1926
    OrganismiRoseiflexus sp. (strain RS-1)
    Taxonomic identifieri357808 [NCBI]
    Taxonomic lineageiBacteriaChloroflexiChloroflexiaChloroflexalesRoseiflexineaeRoseiflexaceaeRoseiflexus
    ProteomesiUP000006554: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 270270Hydroxyethylthiazole kinasePRO_0000336568Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi357808.RoseRS_1926.

    Structurei

    3D structure databases

    ProteinModelPortaliA5UUL2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Thz kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2145.
    HOGENOMiHOG000114352.
    KOiK00878.
    OMAiQTFTANV.
    OrthoDBiEOG628F8M.

    Family and domain databases

    Gene3Di3.40.1190.20. 1 hit.
    HAMAPiMF_00228. Thz_kinase.
    InterProiIPR000417. Hyethyz_kinase.
    IPR029056. Ribokinase-like.
    [Graphical view]
    PfamiPF02110. HK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000513. Thz_kinase. 1 hit.
    PRINTSiPR01099. HYETHTZKNASE.
    SUPFAMiSSF53613. SSF53613. 1 hit.
    TIGRFAMsiTIGR00694. thiM. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A5UUL2-1 [UniParc]FASTAAdd to Basket

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    MDPINQRIGD MLARIRATRP LIHHITNLVV MNDTANVTLH VGGLPVMAHD    50
    AEEVAEMVAH AGALVLNVGT LSPDWIESML IAGRRANELQ TPVVLDPVGA 100
    GATQLRTRTN LELLRSLRIA VVRGNGGEIG ALSGEGGEVK GVESVSGPED 150
    PLTAARRLAQ TYHTVVALTG ARDIITDGER VLTVNNGHIW LTTLTGTGCM 200
    ATTMVAAFAA VERDYLLAAA GGLAMFGLAA ELAAEKAHGP ASFKVALFDQ 250
    IYNLTPEQVA NGARVVEGGS 270
    Length:270
    Mass (Da):28,278
    Last modified:July 10, 2007 - v1
    Checksum:i95D1265DD1B55EB9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000686 Genomic DNA. Translation: ABQ90315.1.
    RefSeqiWP_011956661.1. NC_009523.1.
    YP_001276265.1. NC_009523.1.

    Genome annotation databases

    EnsemblBacteriaiABQ90315; ABQ90315; RoseRS_1926.
    GeneIDi5208887.
    KEGGirrs:RoseRS_1926.
    PATRICi23352142. VBIRosSp109359_2124.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000686 Genomic DNA. Translation: ABQ90315.1 .
    RefSeqi WP_011956661.1. NC_009523.1.
    YP_001276265.1. NC_009523.1.

    3D structure databases

    ProteinModelPortali A5UUL2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 357808.RoseRS_1926.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ90315 ; ABQ90315 ; RoseRS_1926 .
    GeneIDi 5208887.
    KEGGi rrs:RoseRS_1926.
    PATRICi 23352142. VBIRosSp109359_2124.

    Phylogenomic databases

    eggNOGi COG2145.
    HOGENOMi HOG000114352.
    KOi K00878.
    OMAi QTFTANV.
    OrthoDBi EOG628F8M.

    Enzyme and pathway databases

    UniPathwayi UPA00060 ; UER00139 .
    BioCyci RSP357808:GH5Z-1954-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1190.20. 1 hit.
    HAMAPi MF_00228. Thz_kinase.
    InterProi IPR000417. Hyethyz_kinase.
    IPR029056. Ribokinase-like.
    [Graphical view ]
    Pfami PF02110. HK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000513. Thz_kinase. 1 hit.
    PRINTSi PR01099. HYETHTZKNASE.
    SUPFAMi SSF53613. SSF53613. 1 hit.
    TIGRFAMsi TIGR00694. thiM. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RS-1.

    Entry informationi

    Entry nameiTHIM_ROSS1
    AccessioniPrimary (citable) accession number: A5UUL2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3