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A5UU08 (A5UU08_ROSS1) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Orotate phosphoribosyltransferase HAMAP MF_01208
Short name=OPRT HAMAP MF_01208
Short name=OPRTase HAMAP MF_01208
EC=2.4.2.10 HAMAP MF_01208
Gene names
Name:pyrE HAMAP MF_01208
Ordered Locus Names:RoseRS_1721
OrganismRoseiflexus sp. (strain RS-1) [Complete proteome] [HAMAP] EMBL ABQ90111.1
Taxonomic identifier357808 [NCBI]
Taxonomic lineageBacteria › Chloroflexi › Chloroflexales › Chloroflexaceae › Roseiflexus

Protein attributes

Sequence length211 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) By similarity. HAMAP MF_01208

Catalytic activity

Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_01208

Cofactor

Magnesium By similarity. HAMAP MF_01208

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. HAMAP MF_01208

Subunit structure

Homodimer By similarity. HAMAP MF_01208

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily. HAMAP MF_01208

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region120 – 12895-phosphoribose 1-diphosphate binding By similarity HAMAP MF_01208

Sites

Binding site9415-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP MF_01208
Binding site9815-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP MF_01208
Binding site10015-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP MF_01208
Binding site1241Orotate By similarity HAMAP MF_01208

Sequences

Sequence LengthMass (Da)Tools
A5UU08 [UniParc].

Last modified July 10, 2007. Version 1.
Checksum: 42AE82894162F69F

FASTA21122,368
        10         20         30         40         50         60 
MVASSAYDIA RVLIEAGAVL IRPYQPFTFA SGLRSPIYCD NRILLGDVAA RRIVIRSFAA 

        70         80         90        100        110        120 
HCTDASVVSG PATGGIPWVA WVAEMNGIPM AYVRSAAKGH GRGRQIEGAA VGGQRIVLLE 

       130        140        150        160        170        180 
DTVSTGESAL QAAAAIRAEG GVVMRCVCIF TWGWRETTAR FAATDLDLVA LATLADVLEV 

       190        200        210 
AQHTGRLTAD ERTMIEAWAI NPQGWSPPSD G

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References

[1]"Complete sequence of Roseiflexus sp. RS-1."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Mikhailova N., Bryant D.A., Richardson P.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RS-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000686 Genomic DNA. Translation: ABQ90111.1.
RefSeqYP_001276061.1. NC_009523.1.

3D structure databases

ProteinModelPortalA5UU08.
ModBaseSearch...

Protein-protein interaction databases

STRINGA5UU08.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5208678.
GenomeReviewsGene locus RoseRS_1721 in contig CP000686_GR.
KEGGrrs:RoseRS_1721.
PATRIC23351642. VBIRosSp109359_1879.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0461.
HOGENOMHBG404341.
OMALPMTYVR.
ProtClustDBCLSK973736.

Enzyme and pathway databases

BioCycRSP357808:ROSERS_1721-MONOMER.

Family and domain databases

HAMAPMF_01208. PyrE.
[Tree]
InterProIPR023031. Orotate_PribosylTferase.
IPR000836. PRibTrfase.
[Graphical view]
KOK00762.
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA5UU08_ROSS1
AccessionPrimary (citable) accession number: A5UU08
Entry history
Integrated into UniProtKB/TrEMBL: July 10, 2007
Last sequence update: July 10, 2007
Last modified: December 14, 2011
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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