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Protein

Isocitrate dehydrogenase [NADP]

Gene

RoseRS_0785

Organism
Roseiflexus sp. (strain RS-1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Note: Binds 1 magnesium or manganese ion per subunit.
  • Mg2+UniRule annotation, Mn2+UniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciRSP357808:GH5Z-795-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:RoseRS_0785Imported
OrganismiRoseiflexus sp. (strain RS-1)Imported
Taxonomic identifieri357808 [NCBI]
Taxonomic lineageiBacteriaChloroflexiChloroflexiaChloroflexalesRoseiflexineaeRoseiflexaceaeRoseiflexus
ProteomesiUP000006554: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi357808.RoseRS_0785.

Structurei

3D structure databases

ProteinModelPortaliA5URE6.
SMRiA5URE6. Positions 10-452.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000021113.
KOiK00031.
OMAiFRDWGYE.
OrthoDBiEOG6SNDTP.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5URE6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTTRNRAPE GDAISIRNGR LYVPDMPIIP YVEGDGTGPD IWRASVRVFD
60 70 80 90 100
AAVERAYGGR RKLMWYEVLA GEKAFNLTGN WLPDETVEAF RQYLVGIKGP
110 120 130 140 150
LTTPVGRGIR SLNVALRQLL DLYVCLRPVR YFQGVPSPVK RPELVDMVIF
160 170 180 190 200
RENTEDIYAG IEYAAGTPEA QKVLDFLRTT FPKDFEKIRF GTAEKAREFL
210 220 230 240 250
SLLGNGDGEG AVEVGIGIKP VSRLGTERLV AAAIQYAITH RRRSVTFVHK
260 270 280 290 300
GNIMKFTEGA FRDWGYALAE RVFGEHVYTW AQWERTKAEK GEAAANAEQR
310 320 330 340 350
EALAAGAILI KDAIADITLQ QVLTRPEEFD VIATLNLNGD YLSDALAAQV
360 370 380 390 400
GGIGIAPGGN INYITGHAIF EATHGTAPKY ANLDRVNPGS VILSGDMMLR
410 420 430 440 450
YMGWTEAADL IIRALEKTIA QKIVTYDFAR LMTGAKEVKT SQFADAMIAN

MDE
Length:453
Mass (Da):50,046
Last modified:July 10, 2007 - v1
Checksum:i10E9422F8AB8C960
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000686 Genomic DNA. Translation: ABQ89199.1.
RefSeqiWP_011955553.1. NC_009523.1.
YP_001275149.1. NC_009523.1.

Genome annotation databases

EnsemblBacteriaiABQ89199; ABQ89199; RoseRS_0785.
GeneIDi5207728.
KEGGirrs:RoseRS_0785.
PATRICi23349567. VBIRosSp109359_0855.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000686 Genomic DNA. Translation: ABQ89199.1.
RefSeqiWP_011955553.1. NC_009523.1.
YP_001275149.1. NC_009523.1.

3D structure databases

ProteinModelPortaliA5URE6.
SMRiA5URE6. Positions 10-452.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi357808.RoseRS_0785.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABQ89199; ABQ89199; RoseRS_0785.
GeneIDi5207728.
KEGGirrs:RoseRS_0785.
PATRICi23349567. VBIRosSp109359_0855.

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000021113.
KOiK00031.
OMAiFRDWGYE.
OrthoDBiEOG6SNDTP.

Enzyme and pathway databases

BioCyciRSP357808:GH5Z-795-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RS-1Imported.

Entry informationi

Entry nameiA5URE6_ROSS1
AccessioniPrimary (citable) accession number: A5URE6
Entry historyi
Integrated into UniProtKB/TrEMBL: July 10, 2007
Last sequence update: July 10, 2007
Last modified: February 4, 2015
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.