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Protein

Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 1

Gene

accD1

Organism
Roseiflexus sp. (strain RS-1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO2 group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.UniRule annotation

Catalytic activityi

ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: malonyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes malonyl-CoA from acetyl-CoA.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 1 (accD1), Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (accA), Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (accA), Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 2 (accD2)
This subpathway is part of the pathway malonyl-CoA biosynthesis, which is itself part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes malonyl-CoA from acetyl-CoA, the pathway malonyl-CoA biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi30ZincUniRule annotation1
Metal bindingi33ZincUniRule annotation1
Metal bindingi49ZincUniRule annotation1
Metal bindingi51ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri30 – 51C4-typeUniRule annotationAdd BLAST22

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00655; UER00711.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 1UniRule annotation (EC:6.4.1.2UniRule annotation)
Short name:
ACCase subunit beta 1UniRule annotation
Short name:
Acetyl-CoA carboxylase carboxyltransferase subunit beta 1UniRule annotation
Gene namesi
Name:accD1UniRule annotation
Ordered Locus Names:RoseRS_0392
OrganismiRoseiflexus sp. (strain RS-1)
Taxonomic identifieri357808 [NCBI]
Taxonomic lineageiBacteriaChloroflexiChloroflexiaChloroflexalesRoseiflexineaeRoseiflexaceaeRoseiflexus
Proteomesi
  • UP000006554 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003898421 – 300Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 1Add BLAST300

Interactioni

Subunit structurei

Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).UniRule annotation

Protein-protein interaction databases

STRINGi357808.RoseRS_0392.

Structurei

3D structure databases

ProteinModelPortaliA5UQC0.
SMRiA5UQC0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 294CoA carboxyltransferase N-terminalPROSITE-ProRule annotationAdd BLAST269

Sequence similaritiesi

Belongs to the AccD/PCCB family.UniRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri30 – 51C4-typeUniRule annotationAdd BLAST22

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG4108IDZ. Bacteria.
COG0777. LUCA.
HOGENOMiHOG000021671.
KOiK01963.
OMAiCAFDFRF.
OrthoDBiPOG091H04JK.

Family and domain databases

HAMAPiMF_01395. AcetylCoA_CT_beta. 1 hit.
InterProiView protein in InterPro
IPR034733. AcCoA_carboxyl.
IPR000438. Acetyl_CoA_COase_Trfase_b_su.
IPR029045. ClpP/crotonase-like_dom_sf.
IPR011762. COA_CT_N.
PfamiView protein in Pfam
PF01039. Carboxyl_trans. 1 hit.
PRINTSiPR01070. ACCCTRFRASEB.
SUPFAMiSSF52096. SSF52096. 1 hit.
PROSITEiView protein in PROSITE
PS50980. COA_CT_NTER. 1 hit.

Sequencei

Sequence statusi: Complete.

A5UQC0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDLFRRAPK RFTAARIENQ AIPDNMWVKC PSCGDLIYTR QFSDNLKVCK
60 70 80 90 100
CGYHMRLTAR EWLGLLDDGS FVEFDAALAS VDALGFVSPR HVYEQKLIES
110 120 130 140 150
RQQTGLNDAL ITSSGAINGM LLCLAVTEFE FIGGSMGSAY GERLARVIER
160 170 180 190 200
AADARLPLLT INASGGARQE EGTLALLQMA KVNMALTRLA AAGQPHIALL
210 220 230 240 250
VDPCYGGVLA SYTSVADVII AEPGARVGFA GRRVIEQTIR QKLPVHFQTA
260 270 280 290 300
EFLLDHGMID MVTPRSELRG VLSTLLRLYR DAFAHTSAAQ HVPALTHVQG
Length:300
Mass (Da):32,773
Last modified:July 10, 2007 - v1
Checksum:i2E7983A2F69F28E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000686 Genomic DNA. Translation: ABQ88823.1.
RefSeqiWP_011955180.1. NC_009523.1.

Genome annotation databases

EnsemblBacteriaiABQ88823; ABQ88823; RoseRS_0392.
KEGGirrs:RoseRS_0392.

Similar proteinsi

Entry informationi

Entry nameiACCD1_ROSS1
AccessioniPrimary (citable) accession number: A5UQC0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2009
Last sequence update: July 10, 2007
Last modified: November 22, 2017
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families