Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Roseiflexus sp. (strain RS-1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathway:itetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRSP357808:GH5Z-221-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:RoseRS_0219
OrganismiRoseiflexus sp. (strain RS-1)
Taxonomic identifieri357808 [NCBI]
Taxonomic lineageiBacteriaChloroflexiChloroflexiaChloroflexalesRoseiflexineaeRoseiflexaceaeRoseiflexus
ProteomesiUP000006554 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 564564Formate--tetrahydrofolate ligasePRO_1000068792Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi357808.RoseRS_0219.

Structurei

3D structure databases

ProteinModelPortaliA5UPV2.
SMRiA5UPV2. Positions 4-562.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiCGEIMTM.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5UPV2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSDLDIAQA ARLRPIHAVA ADLGLTDDDI ERYGRNIAKI DLAVLQRLTD
60 70 80 90 100
HPRGRYIVVT AITPTPLGEG KTTTTIGLGQ ALARLGKRSV VTIRQPSMGP
110 120 130 140 150
TFGIKGGAAG GGYSQVVPME PFNLHLTGDI HAVGAAHNLL AAMIDNHLHH
160 170 180 190 200
GNRLDIDPYT VSWTRVVDIS DRALRQVIVG LGGKENGPVR QAQFDITVAS
210 220 230 240 250
EVMAILALTT GLHDLRQRLG RIVVAQTRDG APVTADDLKA AGAMTVLLKE
260 270 280 290 300
AIKPNLLQTL EGSPALVHCG PFANIAHGAS SVLADLIGLH CADYVVTESG
310 320 330 340 350
FGADIGFEKF CDIKCRASGL APDAVVLVAT VRALKAHSGR YAITAGKPLD
360 370 380 390 400
PQLSEENPDD VAAGVANLTA QVRIAKLFGR PVVVAINRFP DDFPSEIEVV
410 420 430 440 450
RQVARDAGAF EVVESFVFAE GGAGGYDLAQ AVMAACEMPG KFTPLYPLDM
460 470 480 490 500
SLRDKIETLA TKVYGAARVE YTPEASRQLT RFEQQGYGAL PICMAKTQLS
510 520 530 540 550
ISHDPKLRGA PSGYVFPIRE VRLAAGAGFI YPLAGDIRTM PGLPAHPAAE
560
RIDIDADGRT VGLS
Length:564
Mass (Da):59,835
Last modified:July 10, 2007 - v1
Checksum:iC80B03E5B19981EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000686 Genomic DNA. Translation: ABQ88655.1.
RefSeqiWP_011955014.1. NC_009523.1.

Genome annotation databases

EnsemblBacteriaiABQ88655; ABQ88655; RoseRS_0219.
KEGGirrs:RoseRS_0219.
PATRICi23348326. VBIRosSp109359_0241.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000686 Genomic DNA. Translation: ABQ88655.1.
RefSeqiWP_011955014.1. NC_009523.1.

3D structure databases

ProteinModelPortaliA5UPV2.
SMRiA5UPV2. Positions 4-562.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi357808.RoseRS_0219.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABQ88655; ABQ88655; RoseRS_0219.
KEGGirrs:RoseRS_0219.
PATRICi23348326. VBIRosSp109359_0241.

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiCGEIMTM.
OrthoDBiEOG6PCPSP.

Enzyme and pathway databases

UniPathwayiUPA00193.
BioCyciRSP357808:GH5Z-221-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RS-1.

Entry informationi

Entry nameiFTHS_ROSS1
AccessioniPrimary (citable) accession number: A5UPV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 10, 2007
Last modified: July 22, 2015
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.