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A5UPV2

- FTHS_ROSS1

UniProt

A5UPV2 - FTHS_ROSS1

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Roseiflexus sp. (strain RS-1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (10 Jul 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRSP357808:GH5Z-221-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:RoseRS_0219
    OrganismiRoseiflexus sp. (strain RS-1)
    Taxonomic identifieri357808 [NCBI]
    Taxonomic lineageiBacteriaChloroflexiChloroflexiaChloroflexalesRoseiflexineaeRoseiflexaceaeRoseiflexus
    ProteomesiUP000006554: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 564564Formate--tetrahydrofolate ligasePRO_1000068792Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi357808.RoseRS_0219.

    Structurei

    3D structure databases

    ProteinModelPortaliA5UPV2.
    SMRiA5UPV2. Positions 4-562.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5UPV2-1 [UniParc]FASTAAdd to Basket

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    MLSDLDIAQA ARLRPIHAVA ADLGLTDDDI ERYGRNIAKI DLAVLQRLTD    50
    HPRGRYIVVT AITPTPLGEG KTTTTIGLGQ ALARLGKRSV VTIRQPSMGP 100
    TFGIKGGAAG GGYSQVVPME PFNLHLTGDI HAVGAAHNLL AAMIDNHLHH 150
    GNRLDIDPYT VSWTRVVDIS DRALRQVIVG LGGKENGPVR QAQFDITVAS 200
    EVMAILALTT GLHDLRQRLG RIVVAQTRDG APVTADDLKA AGAMTVLLKE 250
    AIKPNLLQTL EGSPALVHCG PFANIAHGAS SVLADLIGLH CADYVVTESG 300
    FGADIGFEKF CDIKCRASGL APDAVVLVAT VRALKAHSGR YAITAGKPLD 350
    PQLSEENPDD VAAGVANLTA QVRIAKLFGR PVVVAINRFP DDFPSEIEVV 400
    RQVARDAGAF EVVESFVFAE GGAGGYDLAQ AVMAACEMPG KFTPLYPLDM 450
    SLRDKIETLA TKVYGAARVE YTPEASRQLT RFEQQGYGAL PICMAKTQLS 500
    ISHDPKLRGA PSGYVFPIRE VRLAAGAGFI YPLAGDIRTM PGLPAHPAAE 550
    RIDIDADGRT VGLS 564
    Length:564
    Mass (Da):59,835
    Last modified:July 10, 2007 - v1
    Checksum:iC80B03E5B19981EE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000686 Genomic DNA. Translation: ABQ88655.1.
    RefSeqiWP_011955014.1. NC_009523.1.
    YP_001274605.1. NC_009523.1.

    Genome annotation databases

    EnsemblBacteriaiABQ88655; ABQ88655; RoseRS_0219.
    GeneIDi5207154.
    KEGGirrs:RoseRS_0219.
    PATRICi23348326. VBIRosSp109359_0241.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000686 Genomic DNA. Translation: ABQ88655.1 .
    RefSeqi WP_011955014.1. NC_009523.1.
    YP_001274605.1. NC_009523.1.

    3D structure databases

    ProteinModelPortali A5UPV2.
    SMRi A5UPV2. Positions 4-562.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 357808.RoseRS_0219.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ88655 ; ABQ88655 ; RoseRS_0219 .
    GeneIDi 5207154.
    KEGGi rrs:RoseRS_0219.
    PATRICi 23348326. VBIRosSp109359_0241.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci RSP357808:GH5Z-221-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RS-1.

    Entry informationi

    Entry nameiFTHS_ROSS1
    AccessioniPrimary (citable) accession number: A5UPV2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3