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A5UPV2

- FTHS_ROSS1

UniProt

A5UPV2 - FTHS_ROSS1

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Protein
Formate--tetrahydrofolate ligase
Gene
fhs, RoseRS_0219
Organism
Roseiflexus sp. (strain RS-1)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRSP357808:GH5Z-221-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:RoseRS_0219
OrganismiRoseiflexus sp. (strain RS-1)
Taxonomic identifieri357808 [NCBI]
Taxonomic lineageiBacteriaChloroflexiChloroflexiaChloroflexalesRoseiflexineaeRoseiflexaceaeRoseiflexus
ProteomesiUP000006554: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 564564Formate--tetrahydrofolate ligaseUniRule annotation
PRO_1000068792Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi357808.RoseRS_0219.

Structurei

3D structure databases

ProteinModelPortaliA5UPV2.
SMRiA5UPV2. Positions 4-562.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5UPV2-1 [UniParc]FASTAAdd to Basket

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MLSDLDIAQA ARLRPIHAVA ADLGLTDDDI ERYGRNIAKI DLAVLQRLTD    50
HPRGRYIVVT AITPTPLGEG KTTTTIGLGQ ALARLGKRSV VTIRQPSMGP 100
TFGIKGGAAG GGYSQVVPME PFNLHLTGDI HAVGAAHNLL AAMIDNHLHH 150
GNRLDIDPYT VSWTRVVDIS DRALRQVIVG LGGKENGPVR QAQFDITVAS 200
EVMAILALTT GLHDLRQRLG RIVVAQTRDG APVTADDLKA AGAMTVLLKE 250
AIKPNLLQTL EGSPALVHCG PFANIAHGAS SVLADLIGLH CADYVVTESG 300
FGADIGFEKF CDIKCRASGL APDAVVLVAT VRALKAHSGR YAITAGKPLD 350
PQLSEENPDD VAAGVANLTA QVRIAKLFGR PVVVAINRFP DDFPSEIEVV 400
RQVARDAGAF EVVESFVFAE GGAGGYDLAQ AVMAACEMPG KFTPLYPLDM 450
SLRDKIETLA TKVYGAARVE YTPEASRQLT RFEQQGYGAL PICMAKTQLS 500
ISHDPKLRGA PSGYVFPIRE VRLAAGAGFI YPLAGDIRTM PGLPAHPAAE 550
RIDIDADGRT VGLS 564
Length:564
Mass (Da):59,835
Last modified:July 10, 2007 - v1
Checksum:iC80B03E5B19981EE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000686 Genomic DNA. Translation: ABQ88655.1.
RefSeqiWP_011955014.1. NC_009523.1.
YP_001274605.1. NC_009523.1.

Genome annotation databases

EnsemblBacteriaiABQ88655; ABQ88655; RoseRS_0219.
GeneIDi5207154.
KEGGirrs:RoseRS_0219.
PATRICi23348326. VBIRosSp109359_0241.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000686 Genomic DNA. Translation: ABQ88655.1 .
RefSeqi WP_011955014.1. NC_009523.1.
YP_001274605.1. NC_009523.1.

3D structure databases

ProteinModelPortali A5UPV2.
SMRi A5UPV2. Positions 4-562.
ModBasei Search...

Protein-protein interaction databases

STRINGi 357808.RoseRS_0219.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ88655 ; ABQ88655 ; RoseRS_0219 .
GeneIDi 5207154.
KEGGi rrs:RoseRS_0219.
PATRICi 23348326. VBIRosSp109359_0241.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci RSP357808:GH5Z-221-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RS-1.

Entry informationi

Entry nameiFTHS_ROSS1
AccessioniPrimary (citable) accession number: A5UPV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 10, 2007
Last modified: September 3, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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