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A5UPV2 (FTHS_ROSS1) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:RoseRS_0219
OrganismRoseiflexus sp. (strain RS-1) [Complete proteome] [HAMAP]
Taxonomic identifier357808 [NCBI]
Taxonomic lineageBacteriaChloroflexiChloroflexalesChloroflexaceaeRoseiflexus

Protein attributes

Sequence length564 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 564564Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_1000068792

Regions

Nucleotide binding65 – 728ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A5UPV2 [UniParc].

Last modified July 10, 2007. Version 1.
Checksum: C80B03E5B19981EE

FASTA56459,835
        10         20         30         40         50         60 
MLSDLDIAQA ARLRPIHAVA ADLGLTDDDI ERYGRNIAKI DLAVLQRLTD HPRGRYIVVT 

        70         80         90        100        110        120 
AITPTPLGEG KTTTTIGLGQ ALARLGKRSV VTIRQPSMGP TFGIKGGAAG GGYSQVVPME 

       130        140        150        160        170        180 
PFNLHLTGDI HAVGAAHNLL AAMIDNHLHH GNRLDIDPYT VSWTRVVDIS DRALRQVIVG 

       190        200        210        220        230        240 
LGGKENGPVR QAQFDITVAS EVMAILALTT GLHDLRQRLG RIVVAQTRDG APVTADDLKA 

       250        260        270        280        290        300 
AGAMTVLLKE AIKPNLLQTL EGSPALVHCG PFANIAHGAS SVLADLIGLH CADYVVTESG 

       310        320        330        340        350        360 
FGADIGFEKF CDIKCRASGL APDAVVLVAT VRALKAHSGR YAITAGKPLD PQLSEENPDD 

       370        380        390        400        410        420 
VAAGVANLTA QVRIAKLFGR PVVVAINRFP DDFPSEIEVV RQVARDAGAF EVVESFVFAE 

       430        440        450        460        470        480 
GGAGGYDLAQ AVMAACEMPG KFTPLYPLDM SLRDKIETLA TKVYGAARVE YTPEASRQLT 

       490        500        510        520        530        540 
RFEQQGYGAL PICMAKTQLS ISHDPKLRGA PSGYVFPIRE VRLAAGAGFI YPLAGDIRTM 

       550        560 
PGLPAHPAAE RIDIDADGRT VGLS 

« Hide

References

[1]"Complete sequence of Roseiflexus sp. RS-1."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Mikhailova N., Bryant D.A., Richardson P.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RS-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000686 Genomic DNA. Translation: ABQ88655.1.
RefSeqYP_001274605.1. NC_009523.1.

3D structure databases

ProteinModelPortalA5UPV2.
SMRA5UPV2. Positions 4-562.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING357808.RoseRS_0219.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABQ88655; ABQ88655; RoseRS_0219.
GeneID5207154.
KEGGrrs:RoseRS_0219.
PATRIC23348326. VBIRosSp109359_0241.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMACGEIMTM.
OrthoDBEOG6PCPSP.
ProtClustDBCLSK972829.

Enzyme and pathway databases

BioCycRSP357808:GH5Z-221-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_ROSS1
AccessionPrimary (citable) accession number: A5UPV2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 10, 2007
Last modified: April 16, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways