A5UP91 (DNAA_ROSS1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chromosomal replication initiator protein DnaA

Gene names

Name:	dnaA
Ordered Locus Names:	RoseRS_0001

Organism

Roseiflexus sp. (strain RS-1) [Complete proteome] [HAMAP]

Taxonomic identifier

357808 [NCBI]

Taxonomic lineage

Bacteria › Chloroflexi › Chloroflexales › Chloroflexaceae › Roseiflexus

Protein attributes

Sequence length	481 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids By similarity. HAMAP MF_00377
Subcellular location	Cytoplasm By similarity HAMAP MF_00377.
Sequence similarities	Belongs to the DnaA family.

Ontologies

Keywords
Biological process	DNA replication
Cellular component	Cytoplasm
Ligand	ATP-binding DNA-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA-dependent DNA replication initiation Inferred from electronic annotation. Source: InterPro regulation of DNA replication Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA replication origin binding Inferred from electronic annotation. Source: InterPro nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 481	481	Chromosomal replication initiator protein DnaA HAMAP MF_00377		PRO_1000048714
Regions
	Nucleotide binding	182 – 189	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	A5UP91 [UniParc]. Last modified July 10, 2007. Version 1. Checksum: 24C9964245F9F713	FASTA	481	54,281
	10 20 30 40 50 60 MNLTKVWNTT LGSLQVQLPR HEYNTWVRGA TLLEIDNGVA IVRAPNAFIK EGLESRYLAT 70 80 90 100 110 120 LREQLGSVVG FPVDVRVVLA SPDFERFDGA PHNGRSTENE TRRTAQSLPL QPGSSSNGVN 130 140 150 160 170 180 HPLERTPPQQ LELHRAVRSS MLNPRYTFDR FIIGPSNRLA NAACMAVAEH PAQAYNPLFL 190 200 210 220 230 240 YGGVGLGKTH LLHAIGNFVL DRDPEVNVLY VSSETFTNDL INSIRRQQTE EFRIRYRNID 250 260 270 280 290 300 ILLIDDIQFI AGKEQTQEEF FHTFNTLHSA GKQIVISSDR SPKAILTLEE RLRSRFEWGL 310 320 330 340 350 360 IVDVQMPDLE TRTAILRAKA EQSPVPVPQP VIDFLAQRIQ SHIRELEGCL NRVTAFAQMY 370 380 390 400 410 420 NVPVTIEVAT AALSELLDTN RRKRVTPDAI LREVAAFYSV DLRALQGRSR SRNIVIPRQV 430 440 450 460 470 480 AMYLLREETD SSLMEIGQLL GGRDHTTVMY GCEKITEELN SDARLRQEVA TIRERLLHSA G

References

[1]

"Complete sequence of Roseiflexus sp. RS-1." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Mikhailova N., Bryant D.A., Richardson P. Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RS-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000686 Genomic DNA. Translation: ABQ88444.1.
RefSeq	YP_001274394.1. NC_009523.1.
3D structure databases
ProteinModelPortal	A5UP91.
ModBase	Search...
Protein-protein interaction databases
STRING	A5UP91.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5211616.
GenomeReviews	Gene locus RoseRS_0001 in contig CP000686_GR.
KEGG	rrs:RoseRS_0001.
PATRIC	23347841. VBIRosSp109359_0001.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0593.
HOGENOM	HBG695666.
OMA	CHTLNAL.
ProtClustDB	PRK00149.
Enzyme and pathway databases
BioCyc	RSP357808:ROSERS_0001-MONOMER.
Family and domain databases
HAMAP	MF_00377. DnaA_bact. [Tree]
InterPro	IPR003593. ATPase_AAA+_core. IPR001957. Chromosome_initiator_DnaA. IPR020591. Chromosome_initiator_DnaA-like. IPR018312. Chromosome_initiator_DnaA_CS. IPR013159. DnaA_C. IPR013317. DnaA_Hda. IPR010921. Trp_repressor/repl_initiator. [Graphical view]
Gene3D	G3DSA:1.10.1750.10. DnaA_C. 1 hit.
KO	K02313.
Pfam	PF00308. Bac_DnaA. 1 hit. PF08299. Bac_DnaA_C. 1 hit. [Graphical view]
PRINTS	PR00051. DNAA.
SMART	SM00382. AAA. 1 hit. SM00760. Bac_DnaA_C. 1 hit. [Graphical view]
SUPFAM	SSF48295. Trp_repress_rep. 1 hit.
TIGRFAMs	TIGR00362. DnaA. 1 hit.
PROSITE	PS01008. DNAA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DNAA_ROSS1

Accession

Primary (citable) accession number: A5UP91

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 10, 2007
Last modified:	January 25, 2012
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program