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A5UNY1 (A5UNY1_METS3) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Amidophosphoribosyltransferase PIRNR PIRNR000485
Short name=ATase PIRNR PIRNR000485
EC=2.4.2.14 PIRNR PIRNR000485
Alternative name(s):
Glutamine phosphoribosylpyrophosphate amidotransferase PIRNR PIRNR000485
Gene names
Ordered Locus Names:Msm_1704
OrganismMethanobrevibacter smithii (strain PS / ATCC 35061 / DSM 861) [Complete proteome] [HAMAP] EMBL ABQ87909.1
Taxonomic identifier420247 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanobrevibacter

Protein attributes

Sequence length480 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O. PIRNR PIRNR000485

Cofactor

Binds 1 4Fe-4S cluster per subunit By similarity. PIRSR PIRSR000485-3

Binds 1 magnesium ion per subunit By similarity. PIRNR PIRNR000485

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2. PIRNR PIRNR000485

Sequence similarities

In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. PIRNR PIRNR000485

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site161For GATase activity By similarity PIRSR PIRSR000485-1
Metal binding2591Iron-sulfur (4Fe-4S) By similarity PIRSR PIRSR000485-3
Metal binding4051Iron-sulfur (4Fe-4S) By similarity PIRSR PIRSR000485-3
Metal binding4561Iron-sulfur (4Fe-4S) By similarity PIRSR PIRSR000485-3
Metal binding4591Iron-sulfur (4Fe-4S) By similarity PIRSR PIRSR000485-3

Sequences

Sequence LengthMass (Da)Tools
A5UNY1 [UniParc].

Last modified July 10, 2007. Version 1.
Checksum: D6B50DE561FEAB3D

FASTA48053,491
        10         20         30         40         50         60 
MIYGRLSMQG EMQDKCGVVG IHSVDDSKDV SSLIYYCLYA LQHRGQESAG MATFSPDKGL 

        70         80         90        100        110        120 
NYYCGMGLVT DVFKDYEINN LQGNMAIGHV RYSTTGESKL ENSQPFVTDF DDGFIAMAHN 

       130        140        150        160        170        180 
GDIVNSDELR RELIREGYEF KSGTDSEVIC YMLRKEHYSN GKSIIESIEA VSKKLVGSYA 

       190        200        210        220        230        240 
LTILVNGDLY GVRDSAGMKP LAIAKRGDDF IIASETVAFD VINAKFIRDV KPGEVIYFEN 

       250        260        270        280        290        300 
NEIQSYMLEL ADTTSLAHCM FEYVYFARPD STIDEVNVYQ TRLNIGKQLY EQFPIDADVI 

       310        320        330        340        350        360 
IPVPDSSIPA AIGYSRASGI TYGEGLIKNR YVGRTFIMPT QEERELAVRL KLNPIKEAIK 

       370        380        390        400        410        420 
GKKIVLIDDS IVRGTTSKSL IDFVKEAEPA EIHFLVGCPP VVAPCFYGVA MASKKELIAA 

       430        440        450        460        470        480 
NYSIEEIRQQ LDIDTLGYIS LESLVKAIGM PKEDLCLGCL NECYPTELPD DIEAETYYKP

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References

[1]"Genomic and metabolic adaptations of Methanobrevibacter smithii to the human gut."
Samuel B.S., Hansen E.E., Manchester J.K., Coutinho P.M., Henrissat B., Fulton R., Latreille P., Kim K., Wilson R.K., Gordon J.I.
Proc. Natl. Acad. Sci. U.S.A. 104:10643-10648(2007) [PubMed: 17563350] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000678 Genomic DNA. Translation: ABQ87909.1.
RefSeqYP_001274277.1. NC_009515.1.

3D structure databases

ProteinModelPortalA5UNY1.
ModBaseSearch...

Protein-protein interaction databases

STRINGA5UNY1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5217337.
GenomeReviewsGene locus Msm_1704 in contig CP000678_GR.
KEGGmsi:Msm_1704.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGarNOG04070.
HOGENOMHBG392416.
OMAVWAPGEE.
ProtClustDBCLSK797956.

Family and domain databases

InterProIPR005854. Amd_phspho_trans.
IPR000583. GATase_2.
IPR017932. GATase_II.
IPR000836. PRibTrfase.
[Graphical view]
KOK00764.
PANTHERPTHR11907. Amd_phspho_trans. 1 hit.
PfamPF00310. GATase_2. 1 hit.
PF00156. Pribosyltran. 1 hit.
[Graphical view]
PIRSFPIRSF000485. Amd_phspho_trans. 1 hit.
TIGRFAMsTIGR01134. PurF. 1 hit.
PROSITEPS51278. GATASE_TYPE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA5UNY1_METS3
AccessionPrimary (citable) accession number: A5UNY1
Entry history
Integrated into UniProtKB/TrEMBL: July 10, 2007
Last sequence update: July 10, 2007
Last modified: January 25, 2012
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info