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A5UNA1 (AROC_METS3) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Chorismate synthase
EC=4.2.3.5
Alternative name(s):
5-enolpyruvylshikimate-3-phosphate phospholyase
Gene names
Name:aroC
Ordered Locus Names:Msm_1474
OrganismMethanobrevibacter smithii (strain PS / ATCC 35061 / DSM 861) [Complete proteome] [HAMAP]
Taxonomic identifier420247 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanobrevibacter

Protein attributes

Sequence length364 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300

Cofactor

Reduced flavin By similarity. HAMAP MF_00300

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300

Sequence similarities

Belongs to the chorismate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionchorismate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 364364Chorismate synthase HAMAP MF_00300
PRO_1000022513

Sequences

Sequence LengthMass (Da)Tools
A5UNA1 [UniParc].

Last modified July 10, 2007. Version 1.
Checksum: E007EE43782D42DA

FASTA36439,011
        10         20         30         40         50         60 
MANTIGKMFS VTSFGSSHGK AVGAVIDGCP ANLELNTEDI QKELDKRKPG TSGVTTPRKE 

        70         80         90        100        110        120 
EDKVQILSGI FEGKTDGTPI TGVVYNNNQH SKDYSMFKNT PRPSHGDYGW MSKYGNYDYN 

       130        140        150        160        170        180 
GGGRGSGRIT IGHVIAGAIA KKLLKTKNIE IVSQVIQIGD IMAHSNDFDT VKENVEKNSV 

       190        200        210        220        230        240 
RCGDLEAAKA MEELILSKKQ EGDSIGGIVE TVAVGVPAGL GEPVFERLDG DLARILMNIN 

       250        260        270        280        290        300 
AVKGVEIGFG FDVATSCASE INDEYYIEDN KIYTSTNSSG GIIGGISNGM PIISRIAVKP 

       310        320        330        340        350        360 
TPSISKCQKS VNLEKMEAED ITIQGRHDPC ICPRATVVAQ SSVAIVLADH MIRSGYIHPS 


NLEI

« Hide

References

[1]"Genomic and metabolic adaptations of Methanobrevibacter smithii to the human gut."
Samuel B.S., Hansen E.E., Manchester J.K., Coutinho P.M., Henrissat B., Fulton R., Latreille P., Kim K., Wilson R.K., Gordon J.I.
Proc. Natl. Acad. Sci. U.S.A. 104:10643-10648(2007) [PubMed: 17563350] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PS / ATCC 35061 / DSM 861.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000678 Genomic DNA. Translation: ABQ87679.1.
RefSeqYP_001274047.1. NC_009515.1.

3D structure databases

ProteinModelPortalA5UNA1.
ModBaseSearch...

Protein-protein interaction databases

STRINGA5UNA1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5216657.
GenomeReviewsGene locus Msm_1474 in contig CP000678_GR.
KEGGmsi:Msm_1474.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGarNOG04618.
HOGENOMHBG292336.
OMASRFTTQR.
ProtClustDBPRK05382.

Family and domain databases

HAMAPMF_00300. Chorismate_synth.
[Tree]
InterProIPR000453. Chorismate_synth.
IPR020541. Chorismate_synthase_CS.
[Graphical view]
KOK01736.
PANTHERPTHR21085. Chorismate_synth. 1 hit.
PfamPF01264. Chorismate_synt. 1 hit.
[Graphical view]
PIRSFPIRSF001456. Chorismate_synth. 1 hit.
SUPFAMSSF103263. Chorismate_synth. 1 hit.
TIGRFAMsTIGR00033. AroC. 1 hit.
PROSITEPS00787. CHORISMATE_SYNTHASE_1. 1 hit.
PS00788. CHORISMATE_SYNTHASE_2. 1 hit.
PS00789. CHORISMATE_SYNTHASE_3. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAROC_METS3
AccessionPrimary (citable) accession number: A5UNA1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 10, 2007
Last modified: November 16, 2011
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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