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A5UN79

- SYE_METS3

UniProt

A5UN79 - SYE_METS3

Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Methanobrevibacter smithii (strain PS / ATCC 35061 / DSM 861)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (10 Jul 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

    Catalytic activityi

    ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMSMI420247:GHWZ-1490-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
    Alternative name(s):
    Glutamyl-tRNA synthetaseUniRule annotation
    Short name:
    GluRSUniRule annotation
    Gene namesi
    Name:gltXUniRule annotation
    Ordered Locus Names:Msm_1452
    OrganismiMethanobrevibacter smithii (strain PS / ATCC 35061 / DSM 861)
    Taxonomic identifieri420247 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanobrevibacter
    ProteomesiUP000001992: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 555555Glutamate--tRNA ligasePRO_0000331003Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi420247.Msm_1452.

    Structurei

    3D structure databases

    ProteinModelPortaliA5UN79.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi103 – 11311"HIGH" regionAdd
    BLAST

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0008.
    HOGENOMiHOG000073585.
    KOiK01885.
    OMAiYLGWDDP.

    Family and domain databases

    Gene3Di1.10.1160.10. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPiMF_00022_A. Glu_tRNA_synth_A.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR004526. Glu-tRNA-synth_arc/euk.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
    IPR022888. Glu_tRNA_synth_arc.
    IPR011035. Ribosomal_L25/Gln-tRNA_synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR10119. PTHR10119. 1 hit.
    PfamiPF00749. tRNA-synt_1c. 1 hit.
    PF03950. tRNA-synt_1c_C. 1 hit.
    [Graphical view]
    PRINTSiPR00987. TRNASYNTHGLU.
    SUPFAMiSSF50715. SSF50715. 1 hit.
    TIGRFAMsiTIGR00463. gltX_arch. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5UN79-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNDLEEIVYK HALLNAAKHK GSANPGAVIG SIMSQEPDLR SRAKEIGPIA    50
    GKIVAQVNKL SEDEQSAQMA KYHVEVKENK QKKEEGLQEL PGSHDNVVMR 100
    FAPNPSGPLH IGHARAAVPN AEYVKRYGGK LILRIEDTDP KRVFEPAYDL 150
    IPQDLEWLGI KADEVYYQSD RFEIYYDYAR QLIEKGAAYM CTCDGATFKE 200
    LKDNCKPCPC RDNSVEKNLE LWDKFDQMHA GEAVLRVKTD INHKNPAIRD 250
    WVAMRIVEET HPRLGNKYRV YPMMNFSVAV DDHLMGMSHV LRGKDHLANS 300
    EKQKYLYDHM GWDVPEFIHY GRLKMEDIAL STSKALEGIS SGKYSGWDDP 350
    RLGTLKAIAR RGIQPQTIYN LITEIGVKMS DSAISWKKIY GLNRNFLEPI 400
    ANRYFFVENP VEITVDGYED GAVDIERPLH ADHEDRGNRI LPFAGKAYLA 450
    SEDVKDGISR LMDAVNVDID GDKITYNSTS FEQARDLKAK IIQWVPVEDN 500
    VNVSIVMDDA STKTGLGEGA LKDLKVGDVV QFERVGFARL DEIKDNELVF 550
    YYAHK 555
    Length:555
    Mass (Da):62,827
    Last modified:July 10, 2007 - v1
    Checksum:i49F61D8B7532ECDF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000678 Genomic DNA. Translation: ABQ87657.1.
    RefSeqiYP_001274025.1. NC_009515.1.

    Genome annotation databases

    EnsemblBacteriaiABQ87657; ABQ87657; Msm_1452.
    GeneIDi5216855.
    KEGGimsi:Msm_1452.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000678 Genomic DNA. Translation: ABQ87657.1 .
    RefSeqi YP_001274025.1. NC_009515.1.

    3D structure databases

    ProteinModelPortali A5UN79.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 420247.Msm_1452.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ87657 ; ABQ87657 ; Msm_1452 .
    GeneIDi 5216855.
    KEGGi msi:Msm_1452.

    Phylogenomic databases

    eggNOGi COG0008.
    HOGENOMi HOG000073585.
    KOi K01885.
    OMAi YLGWDDP.

    Enzyme and pathway databases

    BioCyci MSMI420247:GHWZ-1490-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1160.10. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPi MF_00022_A. Glu_tRNA_synth_A.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR004526. Glu-tRNA-synth_arc/euk.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
    IPR022888. Glu_tRNA_synth_arc.
    IPR011035. Ribosomal_L25/Gln-tRNA_synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR10119. PTHR10119. 1 hit.
    Pfami PF00749. tRNA-synt_1c. 1 hit.
    PF03950. tRNA-synt_1c_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00987. TRNASYNTHGLU.
    SUPFAMi SSF50715. SSF50715. 1 hit.
    TIGRFAMsi TIGR00463. gltX_arch. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PS / ATCC 35061 / DSM 861.

    Entry informationi

    Entry nameiSYE_METS3
    AccessioniPrimary (citable) accession number: A5UN79
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3