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A5UML0

- GSA_METS3

UniProt

A5UML0 - GSA_METS3

Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Methanobrevibacter smithii (strain PS / ATCC 35061 / DSM 861)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (10 Jul 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: InterPro
    3. transaminase activity Source: InterPro

    GO - Biological processi

    1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Porphyrin biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciMSMI420247:GHWZ-1269-MONOMER.
    UniPathwayiUPA00251; UER00317.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
    Short name:
    GSAUniRule annotation
    Alternative name(s):
    Glutamate-1-semialdehyde aminotransferaseUniRule annotation
    Short name:
    GSA-ATUniRule annotation
    Gene namesi
    Name:hemLUniRule annotation
    Ordered Locus Names:Msm_1233
    OrganismiMethanobrevibacter smithii (strain PS / ATCC 35061 / DSM 861)
    Taxonomic identifieri420247 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanobrevibacter
    ProteomesiUP000001992: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 423423Glutamate-1-semialdehyde 2,1-aminomutasePRO_0000382397Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei259 – 2591N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi420247.Msm_1233.

    Structurei

    3D structure databases

    ProteinModelPortaliA5UML0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0001.
    HOGENOMiHOG000020210.
    KOiK01845.
    OMAiRAIKPYP.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPiMF_00375. HemL_aminotrans_3.
    InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR11986. PTHR11986. 1 hit.
    PfamiPF00202. Aminotran_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR00713. hemL. 1 hit.
    PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5UML0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFSKDLFQES KKFIPGGVSS PVRAFEPYPF FVKKASGSKI YDVDGNKYID    50
    HCLAYGPLIL GHADPKVVRE VSNQLTIGSA YGTPTENEII LAKEVVDRIP 100
    SAEMVRFVNS GGEATMSAIR LARGFTGKDK IIKFDGAYHG AHDYTLVKGE 150
    PGKSCVPDTK GIPLDTAKNT YSVPFNDEEA LSDLIQKDGD NIACLIMEVV 200
    MGNIGCIEPK KGFLEFVRKI TEENNILLIF DEVITGFRLA RGGAQEYYGV 250
    TPDLTTMGKI VGGGLPMGAF AGKKEIMELI APNGPVYQAG TFSGNPISVQ 300
    AGISTLKQLD NQFYKDLERK GNFLRSNIQS IIDEQGYNIT PVGCGSMFQI 350
    YFNPAPVYNN DDAHNSDAKR FLRYFRALLK EGVFIPPSQF ECNFISSAHS 400
    MEDLTQTAEA IEVALEVAFK KKG 423
    Length:423
    Mass (Da):46,375
    Last modified:July 10, 2007 - v1
    Checksum:i568F9F10097A3F4E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000678 Genomic DNA. Translation: ABQ87438.1.
    RefSeqiYP_001273806.1. NC_009515.1.

    Genome annotation databases

    EnsemblBacteriaiABQ87438; ABQ87438; Msm_1233.
    GeneIDi5216017.
    KEGGimsi:Msm_1233.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000678 Genomic DNA. Translation: ABQ87438.1 .
    RefSeqi YP_001273806.1. NC_009515.1.

    3D structure databases

    ProteinModelPortali A5UML0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 420247.Msm_1233.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ87438 ; ABQ87438 ; Msm_1233 .
    GeneIDi 5216017.
    KEGGi msi:Msm_1233.

    Phylogenomic databases

    eggNOGi COG0001.
    HOGENOMi HOG000020210.
    KOi K01845.
    OMAi RAIKPYP.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00317 .
    BioCyci MSMI420247:GHWZ-1269-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPi MF_00375. HemL_aminotrans_3.
    InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR11986. PTHR11986. 1 hit.
    Pfami PF00202. Aminotran_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR00713. hemL. 1 hit.
    PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PS / ATCC 35061 / DSM 861.

    Entry informationi

    Entry nameiGSA_METS3
    AccessioniPrimary (citable) accession number: A5UML0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 1, 2009
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3