A5UMH2 (A5UMH2_METS3) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Non-canonical purine NTP pyrophosphatase HAMAP MF_01405
EC=3.6.1.19 HAMAP MF_01405

Alternative name(s):
Non-standard purine NTP pyrophosphatase HAMAP MF_01405
Nucleoside-triphosphate diphosphatase HAMAP MF_01405
Nucleoside-triphosphate pyrophosphatase HAMAP MF_01405

Gene names

Ordered Locus Names:

Msm_1195

Organism

Methanobrevibacter smithii (strain PS / ATCC 35061 / DSM 861) [Complete proteome] [HAMAP] EMBL ABQ87400.1

Taxonomic identifier

420247 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanobrevibacter

Protein attributes

Sequence length	182 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP/dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions By similarity. HAMAP MF_01405
Catalytic activity	A nucleoside triphosphate + H2O = a nucleotide + diphosphate. HAMAP MF_01405
Cofactor	Binds 1 divalent metal cation ion per subunit; can use either magnesium or manganese By similarity. HAMAP MF_01405
Subunit structure	Homodimer By similarity. HAMAP MF_01405
Sequence similarities	Belongs to the HAM1 NTPase family. HAMAP MF_01405

Ontologies

Keywords
Biological process	Nucleotide metabolism HAMAP MF_01405
Ligand	Magnesium HAMAP MF_01405 Manganese HAMAP MF_01405 Metal-binding HAMAP MF_01405 Nucleotide-binding HAMAP MF_01405
Molecular function	Hydrolase HAMAP MF_01405
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro nucleoside-triphosphate diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Region	6 – 11	6	Substrate binding By similarity HAMAP MF_01405
	Region	63 – 64	2	Substrate binding By similarity HAMAP MF_01405
Sites
	Metal binding	35	1	Magnesium or manganese By similarity HAMAP MF_01405
	Metal binding	63	1	Magnesium or manganese By similarity HAMAP MF_01405
	Binding site	142	1	Substrate By similarity HAMAP MF_01405
	Binding site	162	1	Substrate By similarity HAMAP MF_01405
	Binding site	168	1	Substrate By similarity HAMAP MF_01405

Sequences

	Sequence		Length	Mass (Da)
	A5UMH2 [UniParc]. Last modified July 10, 2007. Version 1. Checksum: 7BE48EC431EEA447	FASTA	182	20,427
	10 20 30 40 50 60 MITFITGNKH KVIEAENIFK DYDINLEHID LGYCEPQGTL EEVAISGAKY ASRKLNKPVI 70 80 90 100 110 120 VEDAGLFIKA LKGFPGTYSS YVQETLGNQG ILKLLDGVND RYAEFRSVIG YCAPNSEPKI 130 140 150 160 170 180 FLGKVIGEIA VEEKGDLGFA FDPIFYVPAE GKTFGELTTE EKNQFSHRKN SLEKFIKWYS IQ

References

[1]

"Genomic and metabolic adaptations of Methanobrevibacter smithii to the human gut." Samuel B.S., Hansen E.E., Manchester J.K., Coutinho P.M., Henrissat B., Fulton R., Latreille P., Kim K., Wilson R.K., Gordon J.I. Proc. Natl. Acad. Sci. U.S.A. 104:10643-10648(2007) [PubMed: 17563350] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000678 Genomic DNA. Translation: ABQ87400.1.
RefSeq	YP_001273768.1. NC_009515.1.
3D structure databases
ProteinModelPortal	A5UMH2.
ModBase	Search...
Protein-protein interaction databases
STRING	A5UMH2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5216850.
GenomeReviews	Gene locus Msm_1195 in contig CP000678_GR.
KEGG	msi:Msm_1195.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG10472.
HOGENOM	HBG697237.
OMA	VEDSGFF.
ProtClustDB	CLSK798170.
Family and domain databases
HAMAP	MF_01405. Non_canon_purine_NTPase. [Tree]
InterPro	IPR002637. Ham1p-like. IPR020922. Nucleoside-triphosphatase. [Graphical view]
KO	K02428.
PANTHER	PTHR11067. Ham1p_like. 1 hit.
Pfam	PF01725. Ham1p_like. 1 hit. [Graphical view]
TIGRFAMs	TIGR00042. TIGR00042. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A5UMH2_METS3

Accession

Primary (citable) accession number: A5UMH2

Entry history

Integrated into UniProtKB/TrEMBL:	July 10, 2007
Last sequence update:	July 10, 2007
Last modified:	January 25, 2012
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)