A5UM21 (A5UM21_METS3) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Dihydroorotate dehydrogenase HAMAP MF_00224
Short name=DHOD HAMAP MF_00224
Short name=DHODase HAMAP MF_00224
Short name=DHOdehase HAMAP MF_00224
EC=1.3.-.- HAMAP MF_00224

Gene names

Name:	pyrD HAMAP MF_00224
Ordered Locus Names:	Msm_1044

Organism

Methanobrevibacter smithii (strain PS / ATCC 35061 / DSM 861) [Complete proteome] [HAMAP] EMBL ABQ87249.1

Taxonomic identifier

420247 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanobrevibacter

Protein attributes

Sequence length	303 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of dihydroorotate to orotate By similarity. HAMAP MF_00224
Catalytic activity	(S)-dihydroorotate + acceptor = orotate + reduced acceptor. HAMAP MF_00224
Cofactor	Binds 1 FMN per subunit By similarity. HAMAP MF_00224
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway. HAMAP MF_00224
Subcellular location	Cytoplasm By similarity HAMAP MF_00224.
Sequence similarities	Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. HAMAP MF_00224

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis HAMAP MF_00224
Cellular component	Cytoplasm HAMAP MF_00224
Ligand	FMN HAMAP MF_00224 Flavoprotein HAMAP MF_00224
Molecular function	Oxidoreductase HAMAP MF_00224 EMBL ABQ87249.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro UMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	dihydroorotate oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	125	1	Nucleophile By similarity PIRSR PIRSR000164-1

Sequences

	Sequence		Length	Mass (Da)
	A5UM21 [UniParc]. Last modified July 10, 2007. Version 1. Checksum: 86B77C19DC4B4B8B	FASTA	303	32,155
	10 20 30 40 50 60 MLRTNVCGVE FRNPLMLAAG VMGSNASSMN WILKSGAAGV VSKSFSLEPN PGYANPTTVG 70 80 90 100 110 120 VECGIINAIG LSNPGAENFK EELKRIDRKG NVSIASIYGA TPEEFSKLVL EIEDYVDMIE 130 140 150 160 170 180 LNISCPHAME GYGASIGQDA NLTHKIVSAA KDSANKPVIA KLTPNVTDIV EIAVAAQDAG 190 200 210 220 230 240 ADALTLINSL GPGMKINIDV ARPVLSNKFG GMSGKAIKPI ALRNVYTVYD NVDIPIIGVG 250 260 270 280 290 300 GISNFEDVVE FLFAGARAVQ IGTSIMDEGV EVFGKINKDL EEFMNKKGYE SIDEMIGLAH EEL

References

[1]

"Genomic and metabolic adaptations of Methanobrevibacter smithii to the human gut." Samuel B.S., Hansen E.E., Manchester J.K., Coutinho P.M., Henrissat B., Fulton R., Latreille P., Kim K., Wilson R.K., Gordon J.I. Proc. Natl. Acad. Sci. U.S.A. 104:10643-10648(2007) [PubMed: 17563350] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000678 Genomic DNA. Translation: ABQ87249.1.
RefSeq	YP_001273617.1. NC_009515.1.
3D structure databases
ProteinModelPortal	A5UM21.
ModBase	Search...
Protein-protein interaction databases
STRING	A5UM21.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5216365.
GenomeReviews	Gene locus Msm_1044 in contig CP000678_GR.
KEGG	msi:Msm_1044.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG04551.
HOGENOM	HBG472415.
OMA	VALRMVW.
ProtClustDB	PRK07259.
Family and domain databases
HAMAP	MF_00224. DHO_dh_type1. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR005720. Dihydroorotate_DH. IPR024920. Dihydroorotate_DH_1. IPR012135. Dihydroorotate_DH_1_2. IPR001295. Dihydroorotate_DH_CS. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K00226.
Pfam	PF01180. DHO_dh. 1 hit. [Graphical view]
PIRSF	PIRSF000164. DHO_oxidase. 1 hit.
TIGRFAMs	TIGR01037. PyrD_sub1_fam. 1 hit.
PROSITE	PS00911. DHODEHASE_1. 1 hit. PS00912. DHODEHASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A5UM21_METS3

Accession

Primary (citable) accession number: A5UM21

Entry history

Integrated into UniProtKB/TrEMBL:	July 10, 2007
Last sequence update:	July 10, 2007
Last modified:	January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)