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A5UM10 (MPTA_METS3) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
GTP cyclohydrolase MptA
EC=3.5.4.n2
Gene names
Name:mptA
Ordered Locus Names:Msm_1033
OrganismMethanobrevibacter smithii (strain PS / ATCC 35061 / DSM 861) [Complete proteome] [HAMAP]
Taxonomic identifier420247 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanobrevibacter ›

Protein attributes

Sequence length311 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin By similarity. HAMAP-Rule MF_01527

Catalytic activity

GTP + H2O = formate + 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate + diphosphate. HAMAP-Rule MF_01527

Cofactor

Binds 1 Fe2+ ion per subunit By similarity.

Pathway

Cofactor biosynthesis; 5,6,7,8-tetrahydromethanopterin biosynthesis. HAMAP-Rule MF_01527

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the GTP cyclohydrolase IV family.

Ontologies

Keywords
   LigandIron
Metal-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_functionGTP cyclohydrolase activity

Inferred from electronic annotation. Source: HAMAP

iron ion binding

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 311311GTP cyclohydrolase MptA HAMAP-Rule MF_01527
PRO_0000300165

Sites

Site1611May be catalytically important By similarity

Sequences

Sequence LengthMass (Da)Tools
A5UM10 [UniParc].

Last modified July 10, 2007. Version 1.
Checksum: 762E71DFB193154A

FASTA31135,092
        10         20         30         40         50         60 
MAVCLPDTQD DTPSIPIKLT RVGVTGVKKL LQLERNNKRP IILVPTFDAF VDLPNDQKGV 

        70         80         90        100        110        120 
HMSRNPEAIS EVLDEVANDS SVEVETLCAK IVSKMMSKHE YAKRVEISMT TDYMFMKESP 

       130        140        150        160        170        180 
VTKNKTQEMA KLKAKAVGYR EDGEIKIRKS IGAEVIGMTV CPCAQESVKE SDKNKLLEFL 

       190        200        210        220        230        240 
DEETTQKVLD TVTFASHNQR GVGTLLIEVP EDREVKGEDI IEIIEESMSS PVCELLKRPD 

       250        260        270        280        290        300 
ENATVLNAHK KPVFVEDCVR NMMEKIAKKY ADFPEDTIIT SRQENHESIH RHNAFAEKVT 

       310 
TMGELKEELR I

« Hide

References

[1]"Genomic and metabolic adaptations of Methanobrevibacter smithii to the human gut."
Samuel B.S., Hansen E.E., Manchester J.K., Coutinho P.M., Henrissat B., Fulton R., Latreille P., Kim K., Wilson R.K., Gordon J.I.
Proc. Natl. Acad. Sci. U.S.A. 104:10643-10648(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PS / ATCC 35061 / DSM 861.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000678 Genomic DNA. Translation: ABQ87238.1.
RefSeqYP_001273606.1. NC_009515.1.

3D structure databases

ProteinModelPortalA5UM10.
ModBaseSearch...

Protein-protein interaction databases

STRING420247.Msm_1033.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABQ87238; ABQ87238; Msm_1033.
GeneID5215852.
KEGGmsi:Msm_1033.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1469.
HOGENOMHOG000280680.
KOK09007.
OMAVEDCVRE.
ProtClustDBPRK13675.

Enzyme and pathway databases

BioCycMSMI420247:GHWZ-1074-MONOMER.
UniPathwayUPA00065.

Family and domain databases

Gene3D3.10.270.10. 1 hit.
HAMAPMF_01527_A. GTP_cyclohydrol_A.
InterProIPR003801. GTP_cyclohydrolase_FolE2/MptA.
IPR022840. GTP_cyclohydrolase_MptA.
IPR002042. Uricase.
[Graphical view]
PfamPF02649. GCHY-1. 1 hit.
[Graphical view]
TIGRFAMsTIGR00294. TIGR00294. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMPTA_METS3
AccessionPrimary (citable) accession number: A5UM10
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 10, 2007
Last modified: May 1, 2013
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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