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A5ULP3 (THIM_METS3) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxyethylthiazole kinase

EC=2.7.1.50
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name=TH kinase
Short name=Thz kinase
Gene names
Name:thiM
Ordered Locus Names:Msm_0916
OrganismMethanobrevibacter smithii (strain PS / ATCC 35061 / DSM 861) [Complete proteome] [HAMAP]
Taxonomic identifier420247 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanobrevibacter

Protein attributes

Sequence length287 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole. HAMAP-Rule MF_00228

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00228

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1. HAMAP-Rule MF_00228

Sequence similarities

Belongs to the Thz kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 287287Hydroxyethylthiazole kinase HAMAP-Rule MF_00228
PRO_0000383914

Sites

Binding site501Substrate; via amide nitrogen By similarity
Binding site1261ATP By similarity
Binding site1851ATP By similarity
Binding site2121Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
A5ULP3 [UniParc].

Last modified July 10, 2007. Version 1.
Checksum: 350D7198E427C80F

FASTA28730,488
        10         20         30         40         50         60 
MTNKEKLLQK IPELLNEVKS KNPLTHCITN FVTVNDCANA VLAIGASPIM SEDIEEVAEV 

        70         80         90        100        110        120 
VSIADALVIN IGKLSHEQVE AMKISSAQAN KINTPVILDP VGVGISQLRN KVTLEIIENY 

       130        140        150        160        170        180 
KLAAIRGNIT EIKTIAKLTG IISESNTAKG VDVSESDIIT QDNLNENADV ISKLAAKLDT 

       190        200        210        220        230        240 
VILASGPIDI LSDGETTIAI DNGDEMMPYI TGSGCMLSSI VGSCIGATNP LEGTMVAALL 

       250        260        270        280 
MTIAGEKARS KVDSENAGTG SFRAYLIDYL YKLDGQTLIN KSNIEIL 

« Hide

References

[1]"Genomic and metabolic adaptations of Methanobrevibacter smithii to the human gut."
Samuel B.S., Hansen E.E., Manchester J.K., Coutinho P.M., Henrissat B., Fulton R., Latreille P., Kim K., Wilson R.K., Gordon J.I.
Proc. Natl. Acad. Sci. U.S.A. 104:10643-10648(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PS / ATCC 35061 / DSM 861.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000678 Genomic DNA. Translation: ABQ87121.1.
RefSeqYP_001273489.1. NC_009515.1.

3D structure databases

ProteinModelPortalA5ULP3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING420247.Msm_0916.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABQ87121; ABQ87121; Msm_0916.
GeneID5217369.
KEGGmsi:Msm_0916.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2145.
HOGENOMHOG000114352.
KOK00878.
OMAQTFTANV.

Enzyme and pathway databases

BioCycMSMI420247:GHWZ-941-MONOMER.
UniPathwayUPA00060; UER00139.

Family and domain databases

Gene3D3.40.1190.20. 1 hit.
HAMAPMF_00228. Thz_kinase.
InterProIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamPF02110. HK. 1 hit.
[Graphical view]
PIRSFPIRSF000513. Thz_kinase. 1 hit.
PRINTSPR01099. HYETHTZKNASE.
SUPFAMSSF53613. SSF53613. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTHIM_METS3
AccessionPrimary (citable) accession number: A5ULP3
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 10, 2007
Last modified: June 11, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways