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A5ULI7 (ARGC_METS3) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
N-acetyl-gamma-glutamyl-phosphate reductase
Short name=AGPR
EC=1.2.1.38
Alternative name(s):
N-acetyl-glutamate semialdehyde dehydrogenase
Short name=NAGSA dehydrogenase
Gene names
Name:argC
Ordered Locus Names:Msm_0860
OrganismMethanobrevibacter smithii (strain PS / ATCC 35061 / DSM 861) [Complete proteome] [HAMAP]
Taxonomic identifier420247 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanobrevibacter ›

Protein attributes

Sequence length339 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP-Rule MF_00150

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP-Rule MF_00150

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginine biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionN-acetyl-gamma-glutamyl-phosphate reductase activity

Inferred from electronic annotation. Source: HAMAP

NAD binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 339339N-acetyl-gamma-glutamyl-phosphate reductase HAMAP-Rule MF_00150
PRO_1000011015

Sites

Active site1441 By similarity

Sequences

Sequence LengthMass (Da)Tools
A5ULI7 [UniParc].

Last modified July 10, 2007. Version 1.
Checksum: 081DAC37CC93F799

FASTA33937,613
        10         20         30         40         50         60 
MYNVAIVGAS GYTGGELLRM LLNHSEVEVN NITSRKYDGT PAHKIHPHIR DSGLVFKNKQ 

        70         80         90        100        110        120 
PSELDADIIF TATPHGASMK IVPDLLETGT KVIDLSGDYR YRDTKVYEKW YGLEHTSDIK 

       130        140        150        160        170        180 
GVYGLPEIYR DEIKKADLVG NPGCFPTGAI LSSYPLVDND LVDRIVIDSK TGVSGAGVNP 

       190        200        210        220        230        240 
SSTTHYPNIA DNVNPYKISS HRHVSEIQQE LHGFEDVKVS FTPHLVPVIR GIQTTSHSFL 

       250        260        270        280        290        300 
REEHSDITPD ELRKFYEKTY GKEYFIKLMD DGEIPHLSSV RGSNFVHIGG FEIDDTGRIV 

       310        320        330 
MLSCIDNLVR GASGQAIQNM NIMLGLDETT GLNHFGLNP

« Hide

References

[1]"Genomic and metabolic adaptations of Methanobrevibacter smithii to the human gut."
Samuel B.S., Hansen E.E., Manchester J.K., Coutinho P.M., Henrissat B., Fulton R., Latreille P., Kim K., Wilson R.K., Gordon J.I.
Proc. Natl. Acad. Sci. U.S.A. 104:10643-10648(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PS / ATCC 35061 / DSM 861.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000678 Genomic DNA. Translation: ABQ87065.1.
RefSeqYP_001273433.1. NC_009515.1.

3D structure databases

ProteinModelPortalA5ULI7.
ModBaseSearch...

Protein-protein interaction databases

STRING420247.Msm_0860.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABQ87065; ABQ87065; Msm_0860.
GeneID5217059.
KEGGmsi:Msm_0860.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0002.
HOGENOMHOG000254902.
KOK00145.
OMAVCRIAVH.
ProtClustDBPRK00436.

Enzyme and pathway databases

BioCycMSMI420247:GHWZ-901-MONOMER.
UniPathwayUPA00068; UER00108.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_00150. ArgC_type1.
InterProIPR000706. AGPR_type-1.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
IPR012280. Semialdhyde_DH_dimer_dom.
[Graphical view]
PfamPF01118. Semialdhyde_dh. 1 hit.
PF02774. Semialdhyde_dhC. 1 hit.
[Graphical view]
SMARTSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR01850. argC. 1 hit.
PROSITEPS01224. ARGC. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARGC_METS3
AccessionPrimary (citable) accession number: A5ULI7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 10, 2007
Last modified: May 1, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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