A5ULI7 (ARGC_METS3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-acetyl-gamma-glutamyl-phosphate reductase
Short name=AGPR
EC=1.2.1.38

Alternative name(s):
N-acetyl-glutamate semialdehyde dehydrogenase
Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	Msm_0860

Organism

Methanobrevibacter smithii (strain PS / ATCC 35061 / DSM 861) [Complete proteome] [HAMAP]

Taxonomic identifier

420247 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanobrevibacter

Protein attributes

Sequence length	339 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150
Subcellular location	Cytoplasm Probable HAMAP MF_00150.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: EC NAD binding Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 339	339	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_00150		PRO_1000011015
Sites
	Active site	144	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A5ULI7 [UniParc]. Last modified July 10, 2007. Version 1. Checksum: 081DAC37CC93F799	FASTA	339	37,613
	10 20 30 40 50 60 MYNVAIVGAS GYTGGELLRM LLNHSEVEVN NITSRKYDGT PAHKIHPHIR DSGLVFKNKQ 70 80 90 100 110 120 PSELDADIIF TATPHGASMK IVPDLLETGT KVIDLSGDYR YRDTKVYEKW YGLEHTSDIK 130 140 150 160 170 180 GVYGLPEIYR DEIKKADLVG NPGCFPTGAI LSSYPLVDND LVDRIVIDSK TGVSGAGVNP 190 200 210 220 230 240 SSTTHYPNIA DNVNPYKISS HRHVSEIQQE LHGFEDVKVS FTPHLVPVIR GIQTTSHSFL 250 260 270 280 290 300 REEHSDITPD ELRKFYEKTY GKEYFIKLMD DGEIPHLSSV RGSNFVHIGG FEIDDTGRIV 310 320 330 MLSCIDNLVR GASGQAIQNM NIMLGLDETT GLNHFGLNP

References

[1]

"Genomic and metabolic adaptations of Methanobrevibacter smithii to the human gut." Samuel B.S., Hansen E.E., Manchester J.K., Coutinho P.M., Henrissat B., Fulton R., Latreille P., Kim K., Wilson R.K., Gordon J.I. Proc. Natl. Acad. Sci. U.S.A. 104:10643-10648(2007) [PubMed: 17563350] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PS / ATCC 35061 / DSM 861.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000678 Genomic DNA. Translation: ABQ87065.1.
RefSeq	YP_001273433.1. NC_009515.1.
3D structure databases
ProteinModelPortal	A5ULI7.
ModBase	Search...
Protein-protein interaction databases
STRING	A5ULI7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5217059.
GenomeReviews	Gene locus Msm_0860 in contig CP000678_GR.
KEGG	msi:Msm_0860.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG05044.
HOGENOM	HBG294213.
OMA	VCRIAVH.
ProtClustDB	PRK00436.
Family and domain databases
HAMAP	MF_00150. ArgC_type1. [Tree]
InterPro	IPR000706. AGPR_type-1. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_dimer_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00145.
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01850. ArgC. 1 hit.
PROSITE	PS01224. ARGC. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_METS3

Accession

Primary (citable) accession number: A5ULI7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 10, 2007
Last modified:	November 16, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program