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Protein

Probable thymidylate kinase

Gene

tmk

Organism
Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + dTMP = ADP + dTDP.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 148ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Nucleotide biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMSMI420247:GHWZ-526-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable thymidylate kinaseUniRule annotation (EC:2.7.4.9UniRule annotation)
Alternative name(s):
dTMP kinaseUniRule annotation
Gene namesi
Name:tmkUniRule annotation
Ordered Locus Names:Msm_0520
OrganismiMethanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS)
Taxonomic identifieri420247 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanobrevibacter
Proteomesi
  • UP000001992 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 192192Probable thymidylate kinasePRO_1000058253Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi420247.Msm_0520.

Structurei

3D structure databases

ProteinModelPortaliA5UKJ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidylate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01891. Archaea.
COG0125. LUCA.
HOGENOMiHOG000229077.
KOiK00943.
OMAiIDVEVAM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00165. Thymidylate_kinase. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR018095. Thymidylate_kin_CS.
IPR018094. Thymidylate_kinase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00041. DTMP_kinase. 1 hit.
PROSITEiPS01331. THYMIDYLATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5UKJ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYIVFEGIDG AGKSTQINLL KDWLDQNGFD VETVVEPTDS EVGKLIRKIL
60 70 80 90 100
QRPDATTDRI QKTLGLLFAA DRMLIMDKLN DDSKVILSDR SFISSLAYQE
110 120 130 140 150
PAEWIEQINK YAKEPDLVLL LDVDVKTSVN RCSKEDEFEN EEFLSKVKAN
160 170 180 190
YLDLISNFNH EIIDASTGVN KVSTDIKKAV APYMGICPDC IR
Length:192
Mass (Da):21,696
Last modified:July 10, 2007 - v1
Checksum:i154BACD1CBD6FB16
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000678 Genomic DNA. Translation: ABQ86725.1.
RefSeqiWP_011953945.1. NC_009515.1.

Genome annotation databases

EnsemblBacteriaiABQ86725; ABQ86725; Msm_0520.
GeneIDi5216955.
KEGGimsi:Msm_0520.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000678 Genomic DNA. Translation: ABQ86725.1.
RefSeqiWP_011953945.1. NC_009515.1.

3D structure databases

ProteinModelPortaliA5UKJ7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi420247.Msm_0520.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABQ86725; ABQ86725; Msm_0520.
GeneIDi5216955.
KEGGimsi:Msm_0520.

Phylogenomic databases

eggNOGiarCOG01891. Archaea.
COG0125. LUCA.
HOGENOMiHOG000229077.
KOiK00943.
OMAiIDVEVAM.

Enzyme and pathway databases

BioCyciMSMI420247:GHWZ-526-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00165. Thymidylate_kinase. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR018095. Thymidylate_kin_CS.
IPR018094. Thymidylate_kinase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00041. DTMP_kinase. 1 hit.
PROSITEiPS01331. THYMIDYLATE_KINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKTHY_METS3
AccessioniPrimary (citable) accession number: A5UKJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 10, 2007
Last modified: September 7, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.