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A5UKA1 (TF2B_METS3) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcription initiation factor IIB

Short name=TFIIB
Gene names
Name:tfb
Ordered Locus Names:Msm_0424
OrganismMethanobrevibacter smithii (strain PS / ATCC 35061 / DSM 861) [Complete proteome] [HAMAP]
Taxonomic identifier420247 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanobrevibacter

Protein attributes

Sequence length310 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB) By similarity. HAMAP-Rule MF_00383

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_00383

Sequence similarities

Belongs to the TFIIB family.

Contains 1 TFIIB-type zinc finger.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 310310Transcription initiation factor IIB HAMAP-Rule MF_00383
PRO_1000080112

Regions

Repeat127 – 210841 HAMAP-Rule MF_00383
Repeat221 – 302822 HAMAP-Rule MF_00383
Zinc finger9 – 4133TFIIB-type HAMAP-Rule MF_00383

Sites

Metal binding141Zinc By similarity
Metal binding171Zinc By similarity
Metal binding331Zinc By similarity
Metal binding361Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
A5UKA1 [UniParc].

Last modified July 10, 2007. Version 1.
Checksum: AE6F10D63049695A

FASTA31034,834
        10         20         30         40         50         60 
MQGDVYDKDK QTVCPECGST ELIGDYERAE VVCAHCGLVI DENLVDMGPE WRAFDHEQRD 

        70         80         90        100        110        120 
KRTRVGAPIT YTIHDKGLST MIDWRNKDIY GRDIPARNRA QWYRLRKWQR KIRISGATER 

       130        140        150        160        170        180 
NLAFALSELD RDSSRLGLPR SVREAASVVY RSAVDNKLIR GRSIEGVVAA SLYAACRRCN 

       190        200        210        220        230        240 
VPRTLDEIAE VSRVTKKEVG RTYRFLTREL NIKLPPTSPV DYVPRFASEL GLSGEAQSRA 

       250        260        270        280        290        300 
IEIIEKAMEK GLTSGRGPTG VAAAALYIAS VLLGERKTQR DVADIAGVTE VTIRNRYKEL 

       310 
TEQLEMGVTL 

« Hide

References

[1]"Genomic and metabolic adaptations of Methanobrevibacter smithii to the human gut."
Samuel B.S., Hansen E.E., Manchester J.K., Coutinho P.M., Henrissat B., Fulton R., Latreille P., Kim K., Wilson R.K., Gordon J.I.
Proc. Natl. Acad. Sci. U.S.A. 104:10643-10648(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PS / ATCC 35061 / DSM 861.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000678 Genomic DNA. Translation: ABQ86629.1.
RefSeqYP_001272997.1. NC_009515.1.

3D structure databases

ProteinModelPortalA5UKA1.
SMRA5UKA1. Positions 9-55, 114-310.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING420247.Msm_0424.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABQ86629; ABQ86629; Msm_0424.
GeneID5216442.
KEGGmsi:Msm_0424.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1405.
HOGENOMHOG000108633.
KOK03124.
OMAWRAFDHD.
ProtClustDBPRK00423.

Enzyme and pathway databases

BioCycMSMI420247:GHWZ-429-MONOMER.

Family and domain databases

Gene3D1.10.472.10. 2 hits.
HAMAPMF_00383. TF2B_arch.
InterProIPR013763. Cyclin-like.
IPR000812. TFIIB.
IPR023484. TFIIB_arc.
IPR023486. TFIIB_CS.
IPR013150. TFIIB_cyclin.
IPR013137. Znf_TFIIB.
[Graphical view]
PANTHERPTHR11618. PTHR11618. 1 hit.
PfamPF08271. TF_Zn_Ribbon. 1 hit.
PF00382. TFIIB. 2 hits.
[Graphical view]
PRINTSPR00685. TIFACTORIIB.
SMARTSM00385. CYCLIN. 2 hits.
[Graphical view]
SUPFAMSSF47954. SSF47954. 2 hits.
PROSITEPS00782. TFIIB. 2 hits.
PS51134. ZF_TFIIB. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTF2B_METS3
AccessionPrimary (citable) accession number: A5UKA1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 10, 2007
Last modified: February 19, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families