A5UK79 (DCD_METS3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable deoxycytidine triphosphate deaminase
Short name=dCTP deaminase
EC=3.5.4.13

Gene names

Name:	dcd
Ordered Locus Names:	Msm_0402

Organism

Methanobrevibacter smithii (strain PS / ATCC 35061 / DSM 861) [Complete proteome] [HAMAP]

Taxonomic identifier

420247 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanobrevibacter

Protein attributes

Sequence length	194 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	dCTP + H2O = dUTP + NH3. HAMAP MF_00146
Pathway	Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 1/2. HAMAP MF_00146
Sequence similarities	Belongs to the dCTP deaminase family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	dUTP biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	dCTP deaminase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 194	194	Probable deoxycytidine triphosphate deaminase HAMAP MF_00146		PRO_1000009754

Sequences

	Sequence		Length	Mass (Da)
	A5UK79 [UniParc]. Last modified July 10, 2007. Version 1. Checksum: 721451EC632860FA	FASTA	194	21,958
	10 20 30 40 50 60 MAILSDKTIK EYLEEGKIVI DPLKDEQQIQ PSSVDMRLGD EFKVFKVIRK PYIDPKDEED 70 80 90 100 110 120 IAEYMESSTV PEGEAFIIHP NEFALATTQE YVKVPDDLVA RVEGRSSMGR LGVTMHVTAG 130 140 150 160 170 180 YVDPGFEGRI TLEISNIGAM PVALYPGQRV CQLVFETMTT PAELPYGHPK RNSKYMKQLK 190 PESSRVKLDY ELKK

References

[1]

"Genomic and metabolic adaptations of Methanobrevibacter smithii to the human gut." Samuel B.S., Hansen E.E., Manchester J.K., Coutinho P.M., Henrissat B., Fulton R., Latreille P., Kim K., Wilson R.K., Gordon J.I. Proc. Natl. Acad. Sci. U.S.A. 104:10643-10648(2007) [PubMed: 17563350] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PS / ATCC 35061 / DSM 861.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000678 Genomic DNA. Translation: ABQ86607.1.
RefSeq	YP_001272975.1. NC_009515.1.
3D structure databases
ProteinModelPortal	A5UK79.
ModBase	Search...
Protein-protein interaction databases
STRING	A5UK79.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5216667.
GenomeReviews	Gene locus Msm_0402 in contig CP000678_GR.
KEGG	msi:Msm_0402.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG05800.
HOGENOM	HBG553199.
OMA	HTAAYID.
ProtClustDB	PRK00416.
Family and domain databases
HAMAP	MF_00146. dCTP_deaminase. [Tree]
InterPro	IPR011962. dCTP_deam. IPR010550. dCTP_deam_bac. IPR008180. dUTP_pyroPase. [Graphical view]
KO	K01494.
Pfam	PF06559. DCD. 1 hit. PF00692. dUTPase. 1 hit. [Graphical view]
TIGRFAMs	TIGR02274. DCTP_deam. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DCD_METS3

Accession

Primary (citable) accession number: A5UK79

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 10, 2007
Last modified:	November 16, 2011
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program