Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

dCTP deaminase, dUMP-forming

Gene

dcd

Organism
Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.UniRule annotation

Catalytic activityi

dCTP + 2 H2O = dUMP + diphosphate + NH3.UniRule annotation

Pathwayi: dUMP biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes dUMP from dCTP.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. dCTP deaminase, dUMP-forming (dcd)
This subpathway is part of the pathway dUMP biosynthesis, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dUMP from dCTP, the pathway dUMP biosynthesis and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei120 – 121Important for bifunctional activityUniRule annotation2
Binding sitei123dCTPUniRule annotation1
Active sitei133Proton donor/acceptorUniRule annotation1
Binding sitei152dCTPUniRule annotation1
Binding sitei166dCTPUniRule annotation1
Binding sitei174dCTPUniRule annotation1
Binding sitei178dCTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi105 – 110dCTP bindingUniRule annotation6
Nucleotide bindingi131 – 133dCTP bindingUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism
LigandNucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00610; UER00667

Names & Taxonomyi

Protein namesi
Recommended name:
dCTP deaminase, dUMP-formingUniRule annotation (EC:3.5.4.30UniRule annotation)
Alternative name(s):
Bifunctional dCTP deaminase:dUTPaseUniRule annotation
DCD-DUTUniRule annotation
Gene namesi
Name:dcdUniRule annotation
Ordered Locus Names:Msm_0402
OrganismiMethanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS)
Taxonomic identifieri420247 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanobrevibacter
Proteomesi
  • UP000001992 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000097541 – 194dCTP deaminase, dUMP-formingAdd BLAST194

Proteomic databases

PRIDEiA5UK79

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Protein-protein interaction databases

STRINGi420247.Msm_0402

Structurei

3D structure databases

ProteinModelPortaliA5UK79
SMRiA5UK79
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dCTP deaminase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04048 Archaea
COG0717 LUCA
HOGENOMiHOG000228601
KOiK01494
OMAiGQLCLFR
OrthoDBiPOG093Z0C6C

Family and domain databases

CDDicd07557 trimeric_dUTPase, 1 hit
Gene3Di2.70.40.10, 1 hit
HAMAPiMF_00146 dCTP_deaminase, 1 hit
InterProiView protein in InterPro
IPR010550 dCTP_deam_bac
IPR011962 dCTP_deaminase
IPR029054 dUTPase-like
IPR036157 dUTPase-like_sf
IPR033704 dUTPase_trimeric
PfamiView protein in Pfam
PF06559 DCD, 1 hit
PF00692 dUTPase, 1 hit
SUPFAMiSSF51283 SSF51283, 1 hit
TIGRFAMsiTIGR02274 dCTP_deam, 1 hit

Sequencei

Sequence statusi: Complete.

A5UK79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAILSDKTIK EYLEEGKIVI DPLKDEQQIQ PSSVDMRLGD EFKVFKVIRK
60 70 80 90 100
PYIDPKDEED IAEYMESSTV PEGEAFIIHP NEFALATTQE YVKVPDDLVA
110 120 130 140 150
RVEGRSSMGR LGVTMHVTAG YVDPGFEGRI TLEISNIGAM PVALYPGQRV
160 170 180 190
CQLVFETMTT PAELPYGHPK RNSKYMKQLK PESSRVKLDY ELKK
Length:194
Mass (Da):21,958
Last modified:July 10, 2007 - v1
Checksum:i721451EC632860FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000678 Genomic DNA Translation: ABQ86607.1
RefSeqiWP_011953868.1, NC_009515.1

Genome annotation databases

EnsemblBacteriaiABQ86607; ABQ86607; Msm_0402
GeneIDi5216667
KEGGimsi:Msm_0402
PATRICifig|420247.28.peg.405

Similar proteinsi

Entry informationi

Entry nameiDCDB_METS3
AccessioniPrimary (citable) accession number: A5UK79
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 10, 2007
Last modified: April 25, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health