A5UJS3 (RNP2_METS3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribonuclease P protein component 2
Short name=RNase P component 2
EC=3.1.26.5

Gene names

Name:	rnp2
Ordered Locus Names:	Msm_0246

Organism

Methanobrevibacter smithii (strain PS / ATCC 35061 / DSM 861) [Complete proteome] [HAMAP]

Taxonomic identifier

420247 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanobrevibacter

Protein attributes

Sequence length	120 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends By similarity. HAMAP MF_00755
Catalytic activity	Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor. HAMAP MF_00755
Subunit structure	Consists of a catalytic RNA component and at least 4 protein subunits Potential.
Sequence similarities	Belongs to the eukaryotic/archaeal RNase P protein component 2 family.

Ontologies

Keywords
Biological process	tRNA processing
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tRNA processing Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ribonuclease P activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 120	120	Ribonuclease P protein component 2 HAMAP MF_00755		PRO_1000148369

Sequences

	Sequence		Length	Mass (Da)
	A5UJS3 [UniParc]. Last modified July 10, 2007. Version 1. Checksum: AF210816FBD4A011	FASTA	120	13,991
	10 20 30 40 50 60 MKLKVLPPTL RKNNRYLALD IKVKSVISKD DLVNIVWNGC IRFFGENGTG NFSLWVMKFY 70 80 90 100 110 120 ELEKTDEYNH YQAILRCQRE YVDEVRASLA LIYKHNRKDI SVSTIGLSGT IKACQKFIEK

References

[1]

"Genomic and metabolic adaptations of Methanobrevibacter smithii to the human gut." Samuel B.S., Hansen E.E., Manchester J.K., Coutinho P.M., Henrissat B., Fulton R., Latreille P., Kim K., Wilson R.K., Gordon J.I. Proc. Natl. Acad. Sci. U.S.A. 104:10643-10648(2007) [PubMed: 17563350] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PS / ATCC 35061 / DSM 861.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000678 Genomic DNA. Translation: ABQ86451.1.
RefSeq	YP_001272819.1. NC_009515.1.
3D structure databases
ProteinModelPortal	A5UJS3.
ModBase	Search...
Protein-protein interaction databases
STRING	A5UJS3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5216636.
GenomeReviews	Gene locus Msm_0246 in contig CP000678_GR.
KEGG	msi:Msm_0246.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG12799.
HOGENOM	HBG551631.
OMA	NPWLIDY.
ProtClustDB	CLSK2791093.
Family and domain databases
HAMAP	MF_00755. RNase_P_2. [Tree]
InterPro	IPR002759. RNase_P/MRP_subunit. [Graphical view]
KO	K03537.
Pfam	PF01900. RNase_P_Rpp14. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RNP2_METS3

Accession

Primary (citable) accession number: A5UJS3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	July 10, 2007
Last modified:	November 16, 2011
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program