Reviewed, UniProtKB/Swiss-Prot A5UJQ8 (AROD_METS3)

Names and origin

Protein names

Recommended name:
    3-dehydroquinate dehydratase
      Short name=3-dehydroquinase
    EC=4.2.1.10
Alternative name(s):
    Type I DHQase

Gene names

Name:	aroD
Ordered Locus Names:	Msm_0231

Organism

Methanobrevibacter smithii (strain PS / ATCC 35061 / DSM 861) [Complete proteome] [HAMAP]

Taxonomic identifier

420247 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanobrevibacter

Protein attributes

Sequence length	224 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	3-dehydroquinate = 3-dehydroshikimate + H2O. HAMAP MF_00214
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7. HAMAP MF_00214
Sequence similarities	Belongs to the type-I 3-dehydroquinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	3-dehydroquinate dehydratase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 224	224	3-dehydroquinate dehydratase HAMAP MF_00214		PRO_0000325535
Sites
	Active site	120	1	Proton acceptor By similarity
	Active site	146	1	Schiff-base intermediate with substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	A5UJQ8-1 [UniParc]. Last modified July 10, 2007. Version 1. Checksum: C4EF5F4AA9098F0A	FASTA	224	25,198
	10 20 30 40 50 60 MYSQTKIAIP IFQAKKEDVI KVAEDCIEKG ADVLEFRIDA LDNPNFDDIK EIIEEINFPI 70 80 90 100 110 120 IATNRISSEG GSFKGSEEER IDILLKCAPL VDYVDIELQS DDRYIKQIHD TGVTTIVSYH 130 140 150 160 170 180 DFHKTPEINE IMYIVEKEQK LGDIAKVAFM PNDLDDTLKI LAILSHCENT IAISMSDLGS 190 200 210 220 YTRVMASKFD SPITFAAGRD VTAPGQIDIE TMKSLLNMDL NLME

References

[1]

"Genomic and metabolic adaptations of Methanobrevibacter smithii to the human gut." Samuel B.S., Hansen E.E., Manchester J.K., Coutinho P.M., Henrissat B., Fulton R., Latreille P., Kim K., Wilson R.K., Gordon J.I. Proc. Natl. Acad. Sci. U.S.A. 104:10643-10648(2007) [PubMed: 17563350] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000678 Genomic DNA. Translation: ABQ86436.1.
RefSeq	YP_001272804.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A5UJQ8.
Genome annotation databases
GeneID	5216594.
GenomeReviews	Gene locus Msm_0231 in contig CP000678_GR.
KEGG	msi:Msm_0231.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	IAKLAVM.
Family and domain databases
HAMAP	MF_00214. [Tree]
InterPro	IPR018508. 3-dehydroquinate_DH_AS. IPR001381. DHquinase_I. [Graphical view]
Pfam	PF01487. DHquinase_I. 1 hit. [Graphical view]
ProDom	PD005337. DHquinase_I. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01093. aroD. 1 hit.
PROSITE	PS01028. DEHYDROQUINASE_I. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROD_METS3

Accession

Primary (citable) accession number: A5UJQ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	July 10, 2007
Last modified:	November 3, 2009
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)