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Protein

Argininosuccinate lyase

Gene

argH

Organism
Methanobrevibacter smithii (strain PS / ATCC 35061 / DSM 861)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Ornithine carbamoyltransferase (argF)
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationImported

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesisUniRule annotation

Enzyme and pathway databases

BioCyciMSMI420247:GHWZ-193-MONOMER.
UniPathwayiUPA00068; UER00114.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate lyaseUniRule annotation (EC:4.3.2.1UniRule annotation)
Short name:
ASALUniRule annotation
Alternative name(s):
ArginosuccinaseUniRule annotation
Gene namesi
Name:argHUniRule annotation
Ordered Locus Names:Msm_0192Imported
OrganismiMethanobrevibacter smithii (strain PS / ATCC 35061 / DSM 861)Imported
Taxonomic identifieri420247 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanobrevibacter
Proteomesi
  • UP000001992 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi420247.Msm_0192.

Structurei

3D structure databases

ProteinModelPortaliA5UJL9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 288282Lyase_1InterPro annotationAdd
BLAST
Domaini351 – 42777ASL_C2InterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili153 – 18028Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiarCOG01748. Archaea.
COG0165. LUCA.
HOGENOMiHOG000242744.
KOiK01755.
OMAiGRGKMER.

Family and domain databases

Gene3Di1.10.275.10. 1 hit.
HAMAPiMF_00006. Arg_succ_lyase.
InterProiIPR029419. Arg_succ_lyase_C.
IPR009049. Argininosuccinate_lyase.
IPR024083. Fumarase/histidase_N.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
[Graphical view]
PANTHERiPTHR11444. PTHR11444. 1 hit.
PTHR11444:SF3. PTHR11444:SF3. 1 hit.
PfamiPF14698. ASL_C2. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSiPR00149. FUMRATELYASE.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00838. argH. 1 hit.

Sequencei

Sequence statusi: Complete.

A5UJL9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDEAAEYTS SLEFDKIIFE ADIKTNFAHT LMLKEENIID DEIADNILGA
60 70 80 90 100
LDQLKEDGYN ELVFDPSVED IHMAIENYVT DKIGPTAGFM HTAKSRNDQV
110 120 130 140 150
ATDVRLVLRD KITETQIGIL EFMEGLVEKA GEHLETVFIG YTHLQHAQPI
160 170 180 190 200
TIAHHLMAHV QALKRDYERL EDTYKRVNLN PLGSAAMTTT SFPINRQLTT
210 220 230 240 250
DLLGFDAYLE NSMDGVSSRD FISETVFDLS ALCTTLSKIC EELILWSTYE
260 270 280 290 300
FGIIEMADEY SSTSSIMPQK KNPDVAELAR AKSTIVNGEL VTILTILKAI
310 320 330 340 350
PYTYNRDLQE ITPHLWNAVK VTQDTLSIVT KMLLSVKFKE DRCLELAGTN
360 370 380 390 400
FATATDLADI MVREKQIPFR TAHKIVGRIV NEATASGLKE ADITSEYIDD
410 420 430 440 450
IASELGFEKL GLEDDLVQKA LNPLENVKMR TVPGGPSPAM VEIARDNIKE
460
FLNEEFEKKG I
Length:461
Mass (Da):51,684
Last modified:July 10, 2007 - v1
Checksum:i91B66486CE756C65
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000678 Genomic DNA. Translation: ABQ86397.1.

Genome annotation databases

EnsemblBacteriaiABQ86397; ABQ86397; Msm_0192.
KEGGimsi:Msm_0192.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000678 Genomic DNA. Translation: ABQ86397.1.

3D structure databases

ProteinModelPortaliA5UJL9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi420247.Msm_0192.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABQ86397; ABQ86397; Msm_0192.
KEGGimsi:Msm_0192.

Phylogenomic databases

eggNOGiarCOG01748. Archaea.
COG0165. LUCA.
HOGENOMiHOG000242744.
KOiK01755.
OMAiGRGKMER.

Enzyme and pathway databases

UniPathwayiUPA00068; UER00114.
BioCyciMSMI420247:GHWZ-193-MONOMER.

Family and domain databases

Gene3Di1.10.275.10. 1 hit.
HAMAPiMF_00006. Arg_succ_lyase.
InterProiIPR029419. Arg_succ_lyase_C.
IPR009049. Argininosuccinate_lyase.
IPR024083. Fumarase/histidase_N.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
[Graphical view]
PANTHERiPTHR11444. PTHR11444. 1 hit.
PTHR11444:SF3. PTHR11444:SF3. 1 hit.
PfamiPF14698. ASL_C2. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSiPR00149. FUMRATELYASE.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00838. argH. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PS / ATCC 35061 / DSM 861Imported.

Entry informationi

Entry nameiA5UJL9_METS3
AccessioniPrimary (citable) accession number: A5UJL9
Entry historyi
Integrated into UniProtKB/TrEMBL: July 10, 2007
Last sequence update: July 10, 2007
Last modified: July 6, 2016
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.