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Protein

Argininosuccinate lyase

Gene

argH

Organism
Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Ornithine carbamoyltransferase (argF)
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationImported
Biological processAmino-acid biosynthesis, Arginine biosynthesisUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00068; UER00114

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate lyaseUniRule annotation (EC:4.3.2.1UniRule annotation)
Short name:
ASALUniRule annotation
Alternative name(s):
ArginosuccinaseUniRule annotation
Gene namesi
Name:argHUniRule annotation
Ordered Locus Names:Msm_0192Imported
OrganismiMethanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS)Imported
Taxonomic identifieri420247 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanobrevibacter
Proteomesi
  • UP000001992 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi420247.Msm_0192

Structurei

3D structure databases

ProteinModelPortaliA5UJL9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 288Lyase_1InterPro annotationAdd BLAST282
Domaini351 – 427ASL_C2InterPro annotationAdd BLAST77

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili153 – 180Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiarCOG01748 Archaea
COG0165 LUCA
HOGENOMiHOG000242744
KOiK01755
OMAiSIMPHKK
OrthoDBiPOG093Z09KV

Family and domain databases

CDDicd01359 Argininosuccinate_lyase, 1 hit
Gene3Di1.10.275.102 hits
HAMAPiMF_00006 Arg_succ_lyase, 1 hit
InterProiView protein in InterPro
IPR029419 Arg_succ_lyase_C
IPR009049 Argininosuccinate_lyase
IPR024083 Fumarase/histidase_N
IPR000362 Fumarate_lyase_fam
IPR022761 Fumarate_lyase_N
IPR008948 L-Aspartase-like
PANTHERiPTHR43814 PTHR43814, 1 hit
PfamiView protein in Pfam
PF14698 ASL_C2, 1 hit
PF00206 Lyase_1, 1 hit
PRINTSiPR00149 FUMRATELYASE
SUPFAMiSSF48557 SSF48557, 1 hit
TIGRFAMsiTIGR00838 argH, 1 hit

Sequencei

Sequence statusi: Complete.

A5UJL9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDEAAEYTS SLEFDKIIFE ADIKTNFAHT LMLKEENIID DEIADNILGA
60 70 80 90 100
LDQLKEDGYN ELVFDPSVED IHMAIENYVT DKIGPTAGFM HTAKSRNDQV
110 120 130 140 150
ATDVRLVLRD KITETQIGIL EFMEGLVEKA GEHLETVFIG YTHLQHAQPI
160 170 180 190 200
TIAHHLMAHV QALKRDYERL EDTYKRVNLN PLGSAAMTTT SFPINRQLTT
210 220 230 240 250
DLLGFDAYLE NSMDGVSSRD FISETVFDLS ALCTTLSKIC EELILWSTYE
260 270 280 290 300
FGIIEMADEY SSTSSIMPQK KNPDVAELAR AKSTIVNGEL VTILTILKAI
310 320 330 340 350
PYTYNRDLQE ITPHLWNAVK VTQDTLSIVT KMLLSVKFKE DRCLELAGTN
360 370 380 390 400
FATATDLADI MVREKQIPFR TAHKIVGRIV NEATASGLKE ADITSEYIDD
410 420 430 440 450
IASELGFEKL GLEDDLVQKA LNPLENVKMR TVPGGPSPAM VEIARDNIKE
460
FLNEEFEKKG I
Length:461
Mass (Da):51,684
Last modified:July 10, 2007 - v1
Checksum:i91B66486CE756C65
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000678 Genomic DNA Translation: ABQ86397.1

Genome annotation databases

EnsemblBacteriaiABQ86397; ABQ86397; Msm_0192
KEGGimsi:Msm_0192
PATRICifig|420247.28.peg.196

Similar proteinsi

Entry informationi

Entry nameiA5UJL9_METS3
AccessioniPrimary (citable) accession number: A5UJL9
Entry historyiIntegrated into UniProtKB/TrEMBL: July 10, 2007
Last sequence update: July 10, 2007
Last modified: February 28, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported