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Protein

Cell division protein FtsZ

Gene

ftsZ

Organism
Haemophilus influenzae (strain PittGG)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei167 – 1671GTPUniRule annotation
Binding sitei171 – 1711GTPUniRule annotation
Binding sitei215 – 2151GTPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi26 – 305GTPUniRule annotation
Nucleotide bindingi136 – 1383GTPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, SeptationUniRule annotation

Keywords - Ligandi

GTP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciHINF374931:GJA4-1639-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division protein FtsZUniRule annotation
Gene namesi
Name:ftsZUniRule annotation
Ordered Locus Names:CGSHiGG_09375Imported
OrganismiHaemophilus influenzae (strain PittGG)Imported
Taxonomic identifieri374931 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000001990 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA5UIR7.
SMRiA5UIR7. Positions 17-348.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 233216TubulinInterPro annotationAdd
BLAST
Domaini235 – 356122Tubulin_CInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the FtsZ family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000049094.
KOiK03531.
OMAiAQVIWGI.
OrthoDBiEOG6S7XZG.

Family and domain databases

Gene3Di3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
HAMAPiMF_00909. FtsZ.
InterProiIPR000158. Cell_div_FtsZ.
IPR020805. Cell_div_FtsZ_CS.
IPR024757. FtsZ_C.
IPR008280. Tub_FtsZ_C.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PfamiPF12327. FtsZ_C. 1 hit.
PF00091. Tubulin. 1 hit.
[Graphical view]
PRINTSiPR00423. CELLDVISFTSZ.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
TIGRFAMsiTIGR00065. ftsZ. 1 hit.
PROSITEiPS01134. FTSZ_1. 1 hit.
PS01135. FTSZ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5UIR7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLYPEYPEYD NFNESGALIK VVGVGGGGGN AVNHMVMNMV MNMVKQEMGG
60 70 80 90 100
TFVGESSLTS EEHGRIVFYA VNTDAQALRK SQVQQTVQIG GETTKGLGAG
110 120 130 140 150
ANPNIGRKAA EDDQDEIRKM LEGADMVFIA AGMGGGTGTG AAPVVAKIAK
160 170 180 190 200
ELGILTVAVV TKPFAFEGKK RMQFAELGIK DLSQYVDSMI IIPNQQIQKV
210 220 230 240 250
LPKNAKLIDA FAAANDVLRN SVMGISDMIT SPGLINVDFA DVRTVMSVQG
260 270 280 290 300
QAMIGFGSAV GEPGAGRAEE AARLAVRNDL LEKIDLSNAQ GILVNITAGM
310 320 330 340 350
DLVFDEFNII GETIGSFASE EATVVVGTSL VPEMSDEIRV TIVATGLGEI
360 370 380 390 400
AGNEPIQVVR QGLSTQNIEG EGRVNIVPEL HRRESVEVSR SASEEYQRPL
410 420
DKPITDRLEA FKKNNFFNPA QREEN
Length:425
Mass (Da):45,440
Last modified:July 10, 2007 - v1
Checksum:i4C6FBDD290FE7820
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000672 Genomic DNA. Translation: ABR00673.1.

Genome annotation databases

EnsemblBacteriaiABR00673; ABR00673; CGSHiGG_09375.
KEGGihiq:CGSHiGG_09375.
PATRICi20188095. VBIHaeInf102487_1893.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000672 Genomic DNA. Translation: ABR00673.1.

3D structure databases

ProteinModelPortaliA5UIR7.
SMRiA5UIR7. Positions 17-348.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABR00673; ABR00673; CGSHiGG_09375.
KEGGihiq:CGSHiGG_09375.
PATRICi20188095. VBIHaeInf102487_1893.

Phylogenomic databases

HOGENOMiHOG000049094.
KOiK03531.
OMAiAQVIWGI.
OrthoDBiEOG6S7XZG.

Enzyme and pathway databases

BioCyciHINF374931:GJA4-1639-MONOMER.

Family and domain databases

Gene3Di3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
HAMAPiMF_00909. FtsZ.
InterProiIPR000158. Cell_div_FtsZ.
IPR020805. Cell_div_FtsZ_CS.
IPR024757. FtsZ_C.
IPR008280. Tub_FtsZ_C.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PfamiPF12327. FtsZ_C. 1 hit.
PF00091. Tubulin. 1 hit.
[Graphical view]
PRINTSiPR00423. CELLDVISFTSZ.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
TIGRFAMsiTIGR00065. ftsZ. 1 hit.
PROSITEiPS01134. FTSZ_1. 1 hit.
PS01135. FTSZ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characterization and modeling of the Haemophilus influenzae core and supragenomes based on the complete genomic sequences of Rd and 12 clinical nontypeable strains."
    Hogg J.S., Hu F.Z., Janto B., Boissy R., Hayes J., Keefe R., Post J.C., Ehrlich G.D.
    Genome Biol. 8:R103.1-R103.18(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PittGGImported.

Entry informationi

Entry nameiA5UIR7_HAEIG
AccessioniPrimary (citable) accession number: A5UIR7
Entry historyi
Integrated into UniProtKB/TrEMBL: July 10, 2007
Last sequence update: July 10, 2007
Last modified: July 6, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.