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A5UII8

- LPXB_HAEIG

UniProt

A5UII8 - LPXB_HAEIG

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Haemophilus influenzae (strain PittGG)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (10 Jul 2007)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciHINF374931:GJA4-1560-MONOMER.
    UniPathwayiUPA00359; UER00481.

    Protein family/group databases

    CAZyiGT19. Glycosyltransferase Family 19.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
    Gene namesi
    Name:lpxBUniRule annotation
    Ordered Locus Names:CGSHiGG_08930
    OrganismiHaemophilus influenzae (strain PittGG)
    Taxonomic identifieri374931 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000001990: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 390390Lipid-A-disaccharide synthasePRO_1000049401Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi374931.CGSHiGG_08930.

    Structurei

    3D structure databases

    ProteinModelPortaliA5UII8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0763.
    HOGENOMiHOG000018003.
    KOiK00748.
    OMAiVSPITYR.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A5UII8-1 [UniParc]FASTAAdd to Basket

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    MNKTNPTIAL VAGEVSGDIL GAGLIRQLKA HYPNARFIGI AGTRMLAEGC    50
    KTLVDMEELS VMGLAEILKH LPRLLKIRKN VIQTMLQEKP DVYIGIDAPD 100
    FNLDVELKLK ANGIKTIHYV SPSVWAWRQN RIHKIAKATH QVLAFLPFEK 150
    AFYDKFNVPC RFIGHTMADA IPLKPNRAEA CQMLQIDPAQ RYLAILVGSR 200
    GSEVEFLAEP FLKTALLLKE QFPDLQLLVP LVNEKRRIQF ESIKAKIAPN 250
    LDLHLIDGNA RQAMIAADAT LLASGTAALE AMLCKSPMVV GYRMKPLTYF 300
    LAKRLVKTDY ISLPNLLANE MLVPEMIQEE CTPELLAEKL SAYLSDDESA 350
    VKNRLVLIQH FTDLHQKIQC NADKQAAQAV IDLLEGKENV 390
    Length:390
    Mass (Da):43,540
    Last modified:July 10, 2007 - v1
    Checksum:i9DB2C7B372148241
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000672 Genomic DNA. Translation: ABR00594.1.
    RefSeqiWP_012055378.1. NC_009567.1.
    YP_001292977.1. NC_009567.1.

    Genome annotation databases

    EnsemblBacteriaiABR00594; ABR00594; CGSHiGG_08930.
    GeneIDi5227641.
    KEGGihiq:CGSHiGG_08930.
    PATRICi20187915. VBIHaeInf102487_1804.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000672 Genomic DNA. Translation: ABR00594.1 .
    RefSeqi WP_012055378.1. NC_009567.1.
    YP_001292977.1. NC_009567.1.

    3D structure databases

    ProteinModelPortali A5UII8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 374931.CGSHiGG_08930.

    Protein family/group databases

    CAZyi GT19. Glycosyltransferase Family 19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABR00594 ; ABR00594 ; CGSHiGG_08930 .
    GeneIDi 5227641.
    KEGGi hiq:CGSHiGG_08930.
    PATRICi 20187915. VBIHaeInf102487_1804.

    Phylogenomic databases

    eggNOGi COG0763.
    HOGENOMi HOG000018003.
    KOi K00748.
    OMAi VSPITYR.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .
    BioCyci HINF374931:GJA4-1560-MONOMER.

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Characterization and modeling of the Haemophilus influenzae core and supragenomes based on the complete genomic sequences of Rd and 12 clinical nontypeable strains."
      Hogg J.S., Hu F.Z., Janto B., Boissy R., Hayes J., Keefe R., Post J.C., Ehrlich G.D.
      Genome Biol. 8:R103.1-R103.18(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PittGG.

    Entry informationi

    Entry nameiLPXB_HAEIG
    AccessioniPrimary (citable) accession number: A5UII8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3