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A5UII8

- LPXB_HAEIG

UniProt

A5UII8 - LPXB_HAEIG

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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Haemophilus influenzae (strain PittGG)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciHINF374931:GJA4-1560-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
Gene namesi
Name:lpxBUniRule annotation
Ordered Locus Names:CGSHiGG_08930
OrganismiHaemophilus influenzae (strain PittGG)
Taxonomic identifieri374931 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000001990: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 390390Lipid-A-disaccharide synthasePRO_1000049401Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi374931.CGSHiGG_08930.

Structurei

3D structure databases

ProteinModelPortaliA5UII8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

A5UII8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNKTNPTIAL VAGEVSGDIL GAGLIRQLKA HYPNARFIGI AGTRMLAEGC
60 70 80 90 100
KTLVDMEELS VMGLAEILKH LPRLLKIRKN VIQTMLQEKP DVYIGIDAPD
110 120 130 140 150
FNLDVELKLK ANGIKTIHYV SPSVWAWRQN RIHKIAKATH QVLAFLPFEK
160 170 180 190 200
AFYDKFNVPC RFIGHTMADA IPLKPNRAEA CQMLQIDPAQ RYLAILVGSR
210 220 230 240 250
GSEVEFLAEP FLKTALLLKE QFPDLQLLVP LVNEKRRIQF ESIKAKIAPN
260 270 280 290 300
LDLHLIDGNA RQAMIAADAT LLASGTAALE AMLCKSPMVV GYRMKPLTYF
310 320 330 340 350
LAKRLVKTDY ISLPNLLANE MLVPEMIQEE CTPELLAEKL SAYLSDDESA
360 370 380 390
VKNRLVLIQH FTDLHQKIQC NADKQAAQAV IDLLEGKENV
Length:390
Mass (Da):43,540
Last modified:July 10, 2007 - v1
Checksum:i9DB2C7B372148241
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000672 Genomic DNA. Translation: ABR00594.1.
RefSeqiYP_001292977.1. NC_009567.1.

Genome annotation databases

EnsemblBacteriaiABR00594; ABR00594; CGSHiGG_08930.
GeneIDi5227641.
KEGGihiq:CGSHiGG_08930.
PATRICi20187915. VBIHaeInf102487_1804.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000672 Genomic DNA. Translation: ABR00594.1 .
RefSeqi YP_001292977.1. NC_009567.1.

3D structure databases

ProteinModelPortali A5UII8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 374931.CGSHiGG_08930.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR00594 ; ABR00594 ; CGSHiGG_08930 .
GeneIDi 5227641.
KEGGi hiq:CGSHiGG_08930.
PATRICi 20187915. VBIHaeInf102487_1804.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci HINF374931:GJA4-1560-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Characterization and modeling of the Haemophilus influenzae core and supragenomes based on the complete genomic sequences of Rd and 12 clinical nontypeable strains."
    Hogg J.S., Hu F.Z., Janto B., Boissy R., Hayes J., Keefe R., Post J.C., Ehrlich G.D.
    Genome Biol. 8:R103.1-R103.18(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PittGG.

Entry informationi

Entry nameiLPXB_HAEIG
AccessioniPrimary (citable) accession number: A5UII8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 10, 2007
Last modified: October 29, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3