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Protein

Peptidase E

Gene

pepE

Organism
Haemophilus influenzae (strain PittGG)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids.UniRule annotation

Catalytic activityi

Dipeptidase E catalyzes the hydrolysis of dipeptides Asp-|-Xaa. It does not act on peptides with N-terminal Glu, Asn or Gln, nor does it cleave isoaspartyl peptides.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei123 – 1231Charge relay systemUniRule annotation
Active sitei138 – 1381Charge relay systemUniRule annotation
Active sitei160 – 1601Charge relay systemUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Dipeptidase, Hydrolase, Protease, Serine protease

Enzyme and pathway databases

BioCyciHINF374931:GJA4-1109-MONOMER.

Protein family/group databases

MEROPSiS51.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidase EUniRule annotation (EC:3.4.13.21UniRule annotation)
Alternative name(s):
Alpha-aspartyl dipeptidaseUniRule annotation
Asp-specific dipeptidaseUniRule annotation
Dipeptidase EUniRule annotation
Gene namesi
Name:pepEUniRule annotation
Ordered Locus Names:CGSHiGG_06345
OrganismiHaemophilus influenzae (strain PittGG)
Taxonomic identifieri374931 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000001990 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 234234Peptidase EPRO_1000050612Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA5UHB4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S51 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000281834.
KOiK05995.
OMAiKYTATVR.

Family and domain databases

Gene3Di3.40.50.880. 1 hit.
HAMAPiMF_00510. Peptidase_E. 1 hit.
InterProiIPR029062. Class_I_gatase-like.
IPR005320. Peptidase_S51.
IPR023172. Peptidase_S51_dipeptidase-E.
[Graphical view]
PfamiPF03575. Peptidase_S51. 1 hit.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 1 hit.

Sequencei

Sequence statusi: Complete.

A5UHB4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNMLLLSSS KYKNTGYLEH TLPWLQNFLA DYRGKTIAFV PYAGVRRTFD
60 70 80 90 100
EYEKTVQNAL SYLEMNIVSV HHGKQHRDII EQADVIAIGG GNTFCLLKQL
110 120 130 140 150
YEHNLIDIIR EKVNNSTPYF GWSAGANVVG ASIMTTNDMP ITYPPSFQAL
160 170 180 190 200
QLFPHQINPH FISGKMQGHN GESREERLAE FLLVNPTALV YALPEGSALH
210 220 230
IQNEMATVLG ENPILCFSEN MECGTFDINT TFSY
Length:234
Mass (Da):26,384
Last modified:July 10, 2007 - v1
Checksum:i81092871BBFB8F60
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000672 Genomic DNA. Translation: ABR00170.1.

Genome annotation databases

EnsemblBacteriaiABR00170; ABR00170; CGSHiGG_06345.
KEGGihiq:CGSHiGG_06345.
PATRICi20186806. VBIHaeInf102487_1275.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000672 Genomic DNA. Translation: ABR00170.1.

3D structure databases

ProteinModelPortaliA5UHB4.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiS51.001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABR00170; ABR00170; CGSHiGG_06345.
KEGGihiq:CGSHiGG_06345.
PATRICi20186806. VBIHaeInf102487_1275.

Phylogenomic databases

HOGENOMiHOG000281834.
KOiK05995.
OMAiKYTATVR.

Enzyme and pathway databases

BioCyciHINF374931:GJA4-1109-MONOMER.

Family and domain databases

Gene3Di3.40.50.880. 1 hit.
HAMAPiMF_00510. Peptidase_E. 1 hit.
InterProiIPR029062. Class_I_gatase-like.
IPR005320. Peptidase_S51.
IPR023172. Peptidase_S51_dipeptidase-E.
[Graphical view]
PfamiPF03575. Peptidase_S51. 1 hit.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPEPE_HAEIG
AccessioniPrimary (citable) accession number: A5UHB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 10, 2007
Last modified: September 7, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.