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A5UGF0

- TRMB_HAEIG

UniProt

A5UGF0 - TRMB_HAEIG

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Protein
tRNA (guanine-N(7)-)-methyltransferase
Gene
trmB, CGSHiGG_04505
Organism
Haemophilus influenzae (strain PittGG)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei77 – 771S-adenosyl-L-methionine By similarity
Binding sitei102 – 1021S-adenosyl-L-methionine By similarity
Binding sitei129 – 1291S-adenosyl-L-methionine By similarity
Active sitei152 – 1521 By similarity
Binding sitei152 – 1521S-adenosyl-L-methionine By similarity
Binding sitei156 – 1561Substrate By similarity
Binding sitei188 – 1881Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciHINF374931:GJA4-780-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferase
    tRNA(m7G46)-methyltransferase
    Gene namesi
    Name:trmB
    Ordered Locus Names:CGSHiGG_04505
    OrganismiHaemophilus influenzae (strain PittGG)
    Taxonomic identifieri374931 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000001990: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 246246tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation
    PRO_1000064397Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi374931.CGSHiGG_04505.

    Structurei

    3D structure databases

    ProteinModelPortaliA5UGF0.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni225 – 2284Substrate binding By similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0220.
    HOGENOMiHOG000073968.
    KOiK03439.
    OMAiFATDWEN.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5UGF0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTQTFADQKR KTVETAEFTE DGRYKRKVRS FVLRTGRLSE FQRNMMNDNW    50
    GTLGLDYQTE PFDFAKIYGN DNPVVLEIGF GMGKSLVDMA FANPDKNYLG 100
    IEVHTPGVGA CIAYAVEKGV TNLRVICHDA TEILRDSIAD GTLGGLQLFF 150
    PDPWHKAKHH KRRIVQPHFV TQVIQKLSEN GFIHMATDWE NYAEQMLEVL 200
    SANTDLVNTS KNGNYIPRPD FRPLTKFEAR GHKLGHGVWD LYFVKK 246
    Length:246
    Mass (Da):28,086
    Last modified:July 10, 2007 - v1
    Checksum:iA5AA3F313231B684
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000672 Genomic DNA. Translation: ABQ99855.1.
    RefSeqiWP_012054964.1. NC_009567.1.
    YP_001292239.1. NC_009567.1.

    Genome annotation databases

    EnsemblBacteriaiABQ99855; ABQ99855; CGSHiGG_04505.
    GeneIDi5227352.
    KEGGihiq:CGSHiGG_04505.
    PATRICi20186040. VBIHaeInf102487_0906.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000672 Genomic DNA. Translation: ABQ99855.1 .
    RefSeqi WP_012054964.1. NC_009567.1.
    YP_001292239.1. NC_009567.1.

    3D structure databases

    ProteinModelPortali A5UGF0.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 374931.CGSHiGG_04505.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ99855 ; ABQ99855 ; CGSHiGG_04505 .
    GeneIDi 5227352.
    KEGGi hiq:CGSHiGG_04505.
    PATRICi 20186040. VBIHaeInf102487_0906.

    Phylogenomic databases

    eggNOGi COG0220.
    HOGENOMi HOG000073968.
    KOi K03439.
    OMAi FATDWEN.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci HINF374931:GJA4-780-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization and modeling of the Haemophilus influenzae core and supragenomes based on the complete genomic sequences of Rd and 12 clinical nontypeable strains."
      Hogg J.S., Hu F.Z., Janto B., Boissy R., Hayes J., Keefe R., Post J.C., Ehrlich G.D.
      Genome Biol. 8:R103.1-R103.18(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PittGG.

    Entry informationi

    Entry nameiTRMB_HAEIG
    AccessioniPrimary (citable) accession number: A5UGF0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: July 10, 2007
    Last modified: September 3, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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