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A5UG10 (AROB_HAEIG) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-dehydroquinate synthase
EC=4.2.3.4
Gene names
Name:aroB
Ordered Locus Names:CGSHiGG_03655
OrganismHaemophilus influenzae (strain PittGG) [Complete proteome] [HAMAP]
Taxonomic identifier374931 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length362 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110

Cofactor

Divalent metal cations By similarity. HAMAP MF_00110

NAD By similarity. HAMAP MF_00110

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110

Subunit structure

Monomer By similarity. HAMAP MF_00110

Subcellular location

Cytoplasm By similarity HAMAP MF_00110.

Sequence similarities

Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-dehydroquinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3623623-dehydroquinate synthase HAMAP MF_00110
PRO_1000094527

Sequences

Sequence LengthMass (Da)Tools
A5UG10 [UniParc].

Last modified July 10, 2007. Version 1.
Checksum: 80330AB8D6B16DA3

FASTA36239,878
        10         20         30         40         50         60 
MLCVNVELQE RRYPILIGSG LLQDERSYPI KRGDRVMIVT NPTVAQFYLD IVIYALEKRG 

        70         80         90        100        110        120 
CVVDHVLLPD GEKYKTLESL NLIFTALLQG NHGRDTTIIA LGGGVIGDVA GFAAASYQRG 

       130        140        150        160        170        180 
VRLIQIPTTL LSQVDSSVGG KTAVNHELGK NMIGAFYQPS MVIIDTLTLN TLPKREVNAG 

       190        200        210        220        230        240 
LAEVIKYGAI LDYEFFEWLE QHIDELVALN PEVLQHCISR CCQIKADVVA RDETEKGDRA 

       250        260        270        280        290        300 
LLNLGHTFGH AIETHLGYGN WLHGEAVSTG MMMAAALSEE LGDISIADVS RLEKLLARAN 

       310        320        330        340        350        360 
LPTVSPDTMQ PEDYLPHMMR DKKVLSGKLR LVLLKSLGQA YVANDTAHTL VLNAIRRCTQ 


TD

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References

[1]"Characterization and modeling of the Haemophilus influenzae core and supragenomes based on the complete genomic sequences of Rd and 12 clinical nontypeable strains."
Hogg J.S., Hu F.Z., Janto B., Boissy R., Hayes J., Keefe R., Post J.C., Ehrlich G.D.
Genome Biol. 8:R103.1-R103.18(2007) [PubMed: 17550610] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PittGG.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000672 Genomic DNA. Translation: ABQ99715.1.
RefSeqYP_001292099.1. NC_009567.1.

3D structure databases

ProteinModelPortalA5UG10.
ModBaseSearch...

Protein-protein interaction databases

STRINGA5UG10.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5227206.
GenomeReviewsGene locus CGSHiGG_03655 in contig CP000672_GR.
KEGGhiq:CGSHiGG_03655.
PATRIC20185666. VBIHaeInf102487_0731.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0337.
HOGENOMHBG632303.
OMAGTFTQPD.
ProtClustDBPRK00002.

Family and domain databases

HAMAPMF_00110. DHQ_synthase.
[Tree]
InterProIPR016037. DHQ_synth_AroB.
[Graphical view]
KOK01735.
PANTHERPTHR21090:SF1. DHQ_synth_AroB. 1 hit.
PIRSFPIRSF001455. DHQ_synth. 1 hit.
TIGRFAMsTIGR01357. AroB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROB_HAEIG
AccessionPrimary (citable) accession number: A5UG10
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 10, 2007
Last modified: December 14, 2011
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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