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A5UEJ2

- GLGB_HAEIG

UniProt

A5UEJ2 - GLGB_HAEIG

Protein

1,4-alpha-glucan branching enzyme GlgB

Gene

glgB

Organism
Haemophilus influenzae (strain PittGG)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (10 Jul 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.UniRule annotation

    Catalytic activityi

    Transfers a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei405 – 4051NucleophileUniRule annotation
    Active sitei458 – 4581Proton donorUniRule annotation

    GO - Molecular functioni

    1. 1,4-alpha-glucan branching enzyme activity Source: UniProtKB-HAMAP
    2. cation binding Source: InterPro
    3. hydrolase activity, hydrolyzing O-glycosyl compounds Source: InterPro

    GO - Biological processi

    1. glycogen biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Carbohydrate metabolism, Glycogen biosynthesis, Glycogen metabolism

    Enzyme and pathway databases

    BioCyciHINF374931:GJA4-72-MONOMER.
    UniPathwayiUPA00164.

    Protein family/group databases

    CAZyiCBM48. Carbohydrate-Binding Module Family 48.
    GH13. Glycoside Hydrolase Family 13.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    1,4-alpha-glucan branching enzyme GlgBUniRule annotation (EC:2.4.1.18UniRule annotation)
    Alternative name(s):
    1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferaseUniRule annotation
    Alpha-(1->4)-glucan branching enzymeUniRule annotation
    Glycogen branching enzymeUniRule annotation
    Short name:
    BEUniRule annotation
    Gene namesi
    Name:glgBUniRule annotation
    Ordered Locus Names:CGSHiGG_00440
    OrganismiHaemophilus influenzae (strain PittGG)
    Taxonomic identifieri374931 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000001990: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 7307301,4-alpha-glucan branching enzyme GlgBPRO_1000044980Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi374931.CGSHiGG_00440.

    Structurei

    3D structure databases

    ProteinModelPortaliA5UEJ2.
    SMRiA5UEJ2. Positions 119-730.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0296.
    HOGENOMiHOG000283037.
    KOiK00700.
    OMAiAKLLFMG.
    OrthoDBiEOG6JX7GT.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    2.60.40.1180. 1 hit.
    3.20.20.80. 1 hit.
    HAMAPiMF_00685. GlgB.
    InterProiIPR006048. A-amylase_b_C.
    IPR006407. GlgB.
    IPR015902. Glyco_hydro_13.
    IPR013780. Glyco_hydro_13_b.
    IPR006047. Glyco_hydro_13_cat_dom.
    IPR004193. Glyco_hydro_13_N.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    [Graphical view]
    PANTHERiPTHR10357. PTHR10357. 1 hit.
    PfamiPF00128. Alpha-amylase. 1 hit.
    PF02806. Alpha-amylase_C. 1 hit.
    PF02922. CBM_48. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000463. GlgB. 1 hit.
    SUPFAMiSSF51445. SSF51445. 1 hit.
    SSF81296. SSF81296. 2 hits.
    TIGRFAMsiTIGR01515. branching_enzym. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A5UEJ2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTAVTQAII DGFFDASNGD PFATLGMHET EQGIEIRTLL PDANRMVVIE    50
    RESGKEITEL DCVDERGFFV GVIPNCRQFF AYQLQVFWGN EAQIIEDPYR 100
    FHPMIDDLEQ WLLSEGSMLR PYEVLGAHFM ECDGVSGVNF RLWAPNARRV 150
    SIVGDFNYWD GRRHPMRFHS KSGVWELFLP KASLGQLYKF ELIDCHGNLR 200
    LKADPFAFSS QLRPDTASQV SALPNVVEMT EARKKANQGN QPISIYEVHL 250
    GSWRRNLENN FWLDYDQIAD ELIPYVKEMG FTHIEFLPLS EFPFDGSWGY 300
    QPLGLYSPTS RFGSPEAFSR LVKRAHEAGI NVILDWVPGH FPSDTHGLVA 350
    FDGTALYEHE DPREGYHQDW NTLIYNYGRN EVKNFLSSNA LYWLERFGVD 400
    GIRVDAVASM IYRDYSRVEG EWIPNQYGGR ENLEAIEFLK HTNWKIHSEM 450
    AGAISIAEES TSFAGVTHPS ENGGLGFNFK WNMGWMNDTL AYMKLDPIYR 500
    QYHHNKMTFG MVYQYSENFV LPLSHDEVVH GKYSLLGKMP GDTWQKFANL 550
    RAYYGYMWGY PGKKLLFMGN EFAQGREWNH EESLDWFLLD ENIDGGWHKG 600
    VLKLVKDLNQ IYQKNRPLFE LDNSPEGFDW LVVDDAANSV FAFERRSSNG 650
    ERIIVVSNFT PVPRHDYRIG VNIVGEYEEI LNTDSMYYQG SNVGNFGCVA 700
    SENIESHGRE NSISVSIPPL ATVYLRLKAK 730
    Length:730
    Mass (Da):83,844
    Last modified:July 10, 2007 - v1
    Checksum:i98AC5D5D0F8E1A51
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000672 Genomic DNA. Translation: ABQ99197.1.
    RefSeqiWP_011962031.1. NC_009567.1.
    YP_001291581.1. NC_009567.1.

    Genome annotation databases

    EnsemblBacteriaiABQ99197; ABQ99197; CGSHiGG_00440.
    GeneIDi5227881.
    KEGGihiq:CGSHiGG_00440.
    PATRICi20184315. VBIHaeInf102487_0089.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000672 Genomic DNA. Translation: ABQ99197.1 .
    RefSeqi WP_011962031.1. NC_009567.1.
    YP_001291581.1. NC_009567.1.

    3D structure databases

    ProteinModelPortali A5UEJ2.
    SMRi A5UEJ2. Positions 119-730.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 374931.CGSHiGG_00440.

    Protein family/group databases

    CAZyi CBM48. Carbohydrate-Binding Module Family 48.
    GH13. Glycoside Hydrolase Family 13.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ99197 ; ABQ99197 ; CGSHiGG_00440 .
    GeneIDi 5227881.
    KEGGi hiq:CGSHiGG_00440.
    PATRICi 20184315. VBIHaeInf102487_0089.

    Phylogenomic databases

    eggNOGi COG0296.
    HOGENOMi HOG000283037.
    KOi K00700.
    OMAi AKLLFMG.
    OrthoDBi EOG6JX7GT.

    Enzyme and pathway databases

    UniPathwayi UPA00164 .
    BioCyci HINF374931:GJA4-72-MONOMER.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    2.60.40.1180. 1 hit.
    3.20.20.80. 1 hit.
    HAMAPi MF_00685. GlgB.
    InterProi IPR006048. A-amylase_b_C.
    IPR006407. GlgB.
    IPR015902. Glyco_hydro_13.
    IPR013780. Glyco_hydro_13_b.
    IPR006047. Glyco_hydro_13_cat_dom.
    IPR004193. Glyco_hydro_13_N.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    [Graphical view ]
    PANTHERi PTHR10357. PTHR10357. 1 hit.
    Pfami PF00128. Alpha-amylase. 1 hit.
    PF02806. Alpha-amylase_C. 1 hit.
    PF02922. CBM_48. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000463. GlgB. 1 hit.
    SUPFAMi SSF51445. SSF51445. 1 hit.
    SSF81296. SSF81296. 2 hits.
    TIGRFAMsi TIGR01515. branching_enzym. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Characterization and modeling of the Haemophilus influenzae core and supragenomes based on the complete genomic sequences of Rd and 12 clinical nontypeable strains."
      Hogg J.S., Hu F.Z., Janto B., Boissy R., Hayes J., Keefe R., Post J.C., Ehrlich G.D.
      Genome Biol. 8:R103.1-R103.18(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PittGG.

    Entry informationi

    Entry nameiGLGB_HAEIG
    AccessioniPrimary (citable) accession number: A5UEJ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3