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Protein

Glycerol-3-phosphate acyltransferase

Gene

plsB

Organism
Haemophilus influenzae (strain PittEE)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate.UniRule annotation

Pathwayi: CDP-diacylglycerol biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glycerol-3-phosphate acyltransferase (plsB)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway CDP-diacylglycerol biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate, the pathway CDP-diacylglycerol biosynthesis and in Phospholipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

BioCyciHINF374930:G1G8O-1618-MONOMER
UniPathwayiUPA00557; UER00612

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate acyltransferaseUniRule annotation (EC:2.3.1.15UniRule annotation)
Short name:
GPATUniRule annotation
Gene namesi
Name:plsBUniRule annotation
Ordered Locus Names:CGSHiEE_08365
OrganismiHaemophilus influenzae (strain PittEE)
Taxonomic identifieri374930 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000494341 – 810Glycerol-3-phosphate acyltransferaseAdd BLAST810

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi305 – 310HXXXXD motif6

Domaini

The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.UniRule annotation

Sequence similaritiesi

Belongs to the GPAT/DAPAT family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218231
KOiK00631
OMAiEVIYVPC

Family and domain databases

HAMAPiMF_00393 Glyc3P_acyltrans, 1 hit
InterProiView protein in InterPro
IPR022284 GPAT/DHAPAT
IPR028354 GPAT_PlsB
IPR002123 Plipid/glycerol_acylTrfase
PANTHERiPTHR12563 PTHR12563, 1 hit
PfamiView protein in Pfam
PF01553 Acyltransferase, 1 hit
PIRSFiPIRSF500064 GPAT, 1 hit
PIRSF000437 GPAT_DHAPAT, 1 hit
SMARTiView protein in SMART
SM00563 PlsC, 1 hit
TIGRFAMsiTIGR03703 plsB, 1 hit

Sequencei

Sequence statusi: Complete.

A5UDX7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANFINMYRQ LLSLPLSALV KNNPIPANPI EELSLNIHQP IVYVLPYTSQ
60 70 80 90 100
TDFVIFRRNC LALGLPDPAE KNEINGVKLP RYVYLDEGRR IFKSKGAKDE
110 120 130 140 150
TTTIFNKYLE LHRTSESLDV QLIPVSVLWG RSPGQEDKSD LPNLRLLNGI
160 170 180 190 200
QKTFAAIWFG RDTFVRFSQA VSLRYMVVEH GSDEKIAQKL ARVAKMHFAK
210 220 230 240 250
QRISATGPRL PNRQAMFNKL LQSEAIRRAI EDEAKSKNIS IEKAQKEAYK
260 270 280 290 300
ILDEIAADVS HSSLRAVDRF LRWLWNKLYS GIDVQNSNRV RKLALEGHEI
310 320 330 340 350
VYVPCHRSHI DYLLLSYVLY HQGLVPPHIA AGINLNFWPI GRMFRSWGAF
360 370 380 390 400
FIRRTFKGNR LYSAIFREYL SELFHRGYSV EYFIEGGRSR TGRLLAPKTG
410 420 430 440 450
MMSMTLQALQ HSQTRPISIV PVYVGYEHVL EVDTYAKELR GAAKEKENAG
460 470 480 490 500
LVLRVIKKLR NLGQGFVNFG EPITLSNYLS QHFPDWKEQN HEEKPQWFTP
510 520 530 540 550
AVNNISKQVM ININKAAAVN SMNLVGTALL SSRQRALSRE QLLEQLSSYQ
560 570 580 590 600
QLLQNVPYST DVVLPNVTPQ AMLEHVLALD RIGVLIEKDN FGEIVRLERS
610 620 630 640 650
SAVLMTYYRN NIQHLFVLPS LVASIILHYE AIQKDLLLDA IRKIYPFLQG
660 670 680 690 700
ELFLHFNEDE LNVQIHQIIN EFARQSVINS NDNFLSINKS KVRILQLWSA
710 720 730 740 750
GTREILQRYY ITVTILQKQP AISRAELEKE SQLVAQRLSV LHGINAPEFF
760 770 780 790 800
DKAVFSSFIA NLKEQRYFDE SSYTVLDKIE ELASTLSHLI STEICLTVKG
810
TIEKSEDLSS
Length:810
Mass (Da):92,819
Last modified:July 10, 2007 - v1
Checksum:i0D244E5CB163A13B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000671 Genomic DNA Translation: ABQ98978.1

Genome annotation databases

EnsemblBacteriaiABQ98978; ABQ98978; CGSHiEE_08365
KEGGihip:CGSHiEE_08365

Similar proteinsi

Entry informationi

Entry nameiPLSB_HAEIE
AccessioniPrimary (citable) accession number: A5UDX7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 10, 2007
Last modified: February 28, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

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