Reviewed, UniProtKB/Swiss-Prot A5UDN8 (SYK3_HAEIE)

Names and origin

Protein names

Recommended name:
    Putative lysyl-tRNA synthetase
    EC=6.1.1.6
Alternative name(s):
    Lysine--tRNA ligase
      Short name=LysRS
    GX

Gene names

Name:	poxA
Ordered Locus Names:	CGSHiEE_07880

Organism

Haemophilus influenzae (strain PittEE) [Complete proteome] [HAMAP]

Taxonomic identifier

374930 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	323 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Could be a lysyl-tRNA synthetase. HAMAP MF_00174
Catalytic activity	ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys). HAMAP MF_00174
Sequence similarities	Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lysyl-tRNA aminoacylation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP lysine-tRNA ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 323	323	Putative lysyl-tRNA synthetase HAMAP MF_00174		PRO_1000023623

Sequences

	Sequence		Length	Mass (Da)
	A5UDN8-1 [UniParc]. Last modified July 10, 2007. Version 1. Checksum: 652BB69446F533E9	FASTA	323	37,165
	10 20 30 40 50 60 MTALNHWQPS ADIKNLLKRA KIIAEIRQFF TERGLLEVET PVLSEFGVTD LHLSTFSTEF 70 80 90 100 110 120 LAPFGEQSKT LWLSTSPEYH MKRLLAAGSG PIFQISKVFR NEEAGNRHNP EFTMLEWYRP 130 140 150 160 170 180 HFHMHRLINE VDDLLQQILD CPPAESLSYQ FVFQEYVGLD PLSAERSELI EAARKHNFMA 190 200 210 220 230 240 EDNEDRDTLL QFLFSEVVEP QIGKERPIAV YHFPSTQAAL AQVSPEDQRV AERFEFYYKG 250 260 270 280 290 300 LELANGFHEL ADAQEQRHRF ELDNQQRQKC ELPTREIDER FLAALEAGMP DASGVALGID 310 320 RLMMIALDCE KINDVISFAM DNA

References

[1]

"Characterization and modeling of the Haemophilus influenzae core and supragenomes based on the complete genomic sequences of Rd and 12 clinical nontypeable strains." Hogg J.S., Hu F.Z., Janto B., Boissy R., Hayes J., Keefe R., Post J.C., Ehrlich G.D. Genome Biol. 8:R103.1-R103.18(2007) [PubMed: 17550610] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000671 Genomic DNA. Translation: ABQ98889.1.
RefSeq	YP_001291272.1.
3D structure databases
SMR	A5UDN8. Positions 15-321.
ModBase	Search...
Protein-protein interaction databases
STRING	A5UDN8.
Genome annotation databases
GeneID	5226111.
GenomeReviews	Gene locus CGSHiEE_07880 in contig CP000671_GR.
KEGG	hip:CGSHiEE_07880.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2269.
HOGENOM	HBG631383.
OMA	PGNEAHL.
Family and domain databases
HAMAP	MF_00174. Put_Lys_tRNA_synth. [Tree]
InterPro	IPR004364. aa-tRNA-synt_II. IPR018150. aa-tRNA-synt_II-like. IPR006195. aa-tRNA-synth_II_cons-dom. IPR004525. Lys-tRNA-synth-rel. IPR018149. Lys-tRNA-synth_II_C. [Graphical view]
PANTHER	PTHR22594. aa-tRNA-synt_II. 1 hit.
Pfam	PF00152. tRNA-synt_2. 1 hit. [Graphical view]
PRINTS	PR00982. TRNASYNTHLYS.
TIGRFAMs	TIGR00462. genX. 1 hit.
PROSITE	PS50862. AA_TRNA_LIGASE_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYK3_HAEIE

Accession

Primary (citable) accession number: A5UDN8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 10, 2007
Last modified:	February 9, 2010
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)