Reviewed, UniProtKB/Swiss-Prot A5UDA9 (NAGZ_HAEIE)

Names and origin

Protein names

Recommended name:
    Beta-hexosaminidase
    EC=3.2.1.52
Alternative name(s):
    N-acetyl-beta-glucosaminidase
    Beta-N-acetylhexosaminidase

Gene names

Name:	nagZ
Ordered Locus Names:	CGSHiEE_07165

Organism

Haemophilus influenzae (strain PittEE) [Complete proteome] [HAMAP]

Taxonomic identifier

374930 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	350 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides By similarity.
Catalytic activity	Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. HAMAP MF_00364
Pathway	Cell wall biogenesis; peptidoglycan recycling. HAMAP MF_00364
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.

Ontologies

Keywords
Biological process	Cell cycle Cell division Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cytoplasm
Molecular function	Glycosidase Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan turnover Inferred from electronic annotation. Source: HAMAP regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	beta-N-acetylhexosaminidase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 350	350	Beta-hexosaminidase HAMAP MF_00364		PRO_1000005654
Sites
	Active site	248	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A5UDA9-1 [UniParc]. Last modified July 10, 2007. Version 1. Checksum: 6D496BFCD00FA2C7	FASTA	350	39,626
	10 20 30 40 50 60 MSTLLIDLKG KELEQEEVEL LSHPLVAGLI LFTRNFEDRE QIQELIRSVR QRVKKPLLIT 70 80 90 100 110 120 VDQEGGRVQR FRDGFTMLPS MQAFQETLSA TEQVSFAKEA GWQMAAEMIA LDIDLSFAPV 130 140 150 160 170 180 LDLGHECRAI GDRSFSSDVK SAVNLAINFI DGMHQAGMAS TGKHFPGHGH VLADSHLETP 190 200 210 220 230 240 YDDRTKDEIF GCDLQPFQQL IAQNKLDAIM PAHVIYSQCD SQPASGSEYW LKEILRKKLN 250 260 270 280 290 300 FQGTIFSDDL GMKGAGVMGN FVERSKKALN AGCDLLLLCN EREGVIQVVD NLKLAKNQPH 310 320 330 340 350 FMARQARLQN LFKRRVIDWN DLVSDLRWKL NYRNLADIQI RWLDIQAAKK

References

[1]

"Characterization and modeling of the Haemophilus influenzae core and supragenomes based on the complete genomic sequences of Rd and 12 clinical nontypeable strains." Hogg J.S., Hu F.Z., Janto B., Boissy R., Hayes J., Keefe R., Post J.C., Ehrlich G.D. Genome Biol. 8:RESEARCH103.1-RESEARCH103.18(2007) [PubMed: 17550610] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000671 Genomic DNA. Translation: ABQ98760.1.
RefSeq	YP_001291143.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A5UDA9.
Genome annotation databases
GeneID	5226054.
GenomeReviews	Gene locus CGSHiEE_07165 in contig CP000671_GR.
KEGG	hip:CGSHiEE_07165.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	AKEAGWQ.
Family and domain databases
HAMAP	MF_00364. [Tree]
InterPro	IPR019800. Glyco_hydro_3_AS. IPR001764. Glyco_hydro_3_N. [Graphical view]
Gene3D	G3DSA:3.20.20.300. Glyco_hydro_3_N. 1 hit.
Pfam	PF00933. Glyco_hydro_3. 1 hit. [Graphical view]
PROSITE	PS00775. GLYCOSYL_HYDROL_F3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NAGZ_HAEIE

Accession

Primary (citable) accession number: A5UDA9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 10, 2007
Last modified:	November 3, 2009
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)