A5UCZ3 (XYLA_HAEIE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Xylose isomerase
EC=5.3.1.5

Gene names

Name:	xylA
Ordered Locus Names:	CGSHiEE_06495

Organism

Haemophilus influenzae (strain PittEE) [Complete proteome] [HAMAP]

Taxonomic identifier

374930 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	439 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-xylose = D-xylulose. HAMAP MF_00455
Cofactor	Binds 2 magnesium ions per subunit By similarity. HAMAP MF_00455
Subunit structure	Homotetramer By similarity. HAMAP MF_00455
Subcellular location	Cytoplasm By similarity HAMAP MF_00455.
Sequence similarities	Belongs to the xylose isomerase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Pentose shunt Xylose metabolism
Cellular component	Cytoplasm
Ligand	Magnesium Metal-binding
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	D-xylose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW pentose-phosphate shunt Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW xylose isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 439	439	Xylose isomerase HAMAP MF_00455		PRO_1000026442
Sites
	Active site	101	1	By similarity
	Active site	104	1	By similarity
	Metal binding	232	1	Magnesium 1 By similarity
	Metal binding	268	1	Magnesium 1 By similarity
	Metal binding	268	1	Magnesium 2 By similarity
	Metal binding	271	1	Magnesium 2 By similarity
	Metal binding	296	1	Magnesium 1 By similarity
	Metal binding	307	1	Magnesium 2 By similarity
	Metal binding	309	1	Magnesium 2 By similarity
	Metal binding	339	1	Magnesium 1 By similarity

Sequences

	Sequence		Length	Mass (Da)
	A5UCZ3 [UniParc]. Last modified July 10, 2007. Version 1. Checksum: 24CD3CE4736A3EA6	FASTA	439	49,896
	10 20 30 40 50 60 MTTYFDKIEK ISFEGEKSTN PFAFKHYDAN QVILGKTMAE HLRLAVCYWH TFCWNGNDMF 70 80 90 100 110 120 GLGSLERSWQ KNSNLLAGAE QKADIAFEFL NKLGVPYYCF HDVDIAPEGN SVREYVQNFH 130 140 150 160 170 180 HIVDILERKQ VETGVKLLWG TANCFTNPRY MSGAATNPNP EVFAWAATQV FNAMNATQRL 190 200 210 220 230 240 GGENYVLWGG REGYETLLNT DLKREREQIG RFMQMVVEHK HKIGFKGTLL IEPKPQEPTK 250 260 270 280 290 300 HQYDYDVATV YGFLKQFGLE KEIKVNIEAN HATLAGHTFQ HEIATACALD IFGSIDANRG 310 320 330 340 350 360 DPQLGWDTDQ FPNSVEENTL VMYEILKHGG FTTGGFNFDA KIRRQSIDPY DLFYAHIGAI 370 380 390 400 410 420 DVLALSLKRA AKMLQEETLQ KIVNERYAGW NSELGQHILQ GKTSLETLAQ LVQQKDLAPK 430 PVSGQQEYLE NLVNQVIYS

References

[1]

"Characterization and modeling of the Haemophilus influenzae core and supragenomes based on the complete genomic sequences of Rd and 12 clinical nontypeable strains." Hogg J.S., Hu F.Z., Janto B., Boissy R., Hayes J., Keefe R., Post J.C., Ehrlich G.D. Genome Biol. 8:R103.1-R103.18(2007) [PubMed: 17550610] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PittEE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000671 Genomic DNA. Translation: ABQ98644.1.
RefSeq	YP_001291027.1. NC_009566.1.
3D structure databases
ProteinModelPortal	A5UCZ3.
SMR	A5UCZ3. Positions 3-439.
ModBase	Search...
Protein-protein interaction databases
STRING	A5UCZ3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5225657.
GenomeReviews	Gene locus CGSHiEE_06495 in contig CP000671_GR.
KEGG	hip:CGSHiEE_06495.
PATRIC	20278749. VBIHaeInf81350_1310.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2115.
HOGENOM	HBG297199.
OMA	LLGWDTD.
ProtClustDB	PRK05474.
Enzyme and pathway databases
BioCyc	HINF374930:CGSHIEE_06495-MONOMER.
Family and domain databases
HAMAP	MF_00455. Xylose_isom_A. [Tree]
InterPro	IPR013022. Xyl_isomerase-like_TIM-brl. IPR012307. Xyl_isomerase_TIM-brl. IPR013452. Xylose_isom_bac. IPR001998. Xylose_isomerase. [Graphical view]
Gene3D	G3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit.
KO	K01805.
Pfam	PF01261. AP_endonuc_2. 1 hit. [Graphical view]
PRINTS	PR00688. XYLOSISMRASE.
SUPFAM	SSF51658. Xyl_isomerase-like_TIM-brl. 1 hit.
TIGRFAMs	TIGR02630. Xylose_isom_A. 1 hit.
PROSITE	PS51415. XYLOSE_ISOMERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

XYLA_HAEIE

Accession

Primary (citable) accession number: A5UCZ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 10, 2007
Last modified:	December 14, 2011
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program