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A5UCX0 (MURD_HAEIE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-N-acetylmuramoylalanine--D-glutamate ligase
EC=6.3.2.9
Alternative name(s):
D-glutamic acid-adding enzyme
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase
Gene names
Name:murD
Ordered Locus Names:CGSHiEE_06370
OrganismHaemophilus influenzae (strain PittEE) [Complete proteome] [HAMAP]
Taxonomic identifier374930 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus ›

Protein attributes

Sequence length437 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) By similarity. HAMAP-Rule MF_00639

Catalytic activity

ATP + UDP-N-acetylmuramoyl-L-alanine + glutamate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate. HAMAP-Rule MF_00639

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00639

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the MurCDEF family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 437437UDP-N-acetylmuramoylalanine--D-glutamate ligase HAMAP-Rule MF_00639
PRO_1000056884

Regions

Nucleotide binding112 – 1187ATP Potential

Sequences

Sequence LengthMass (Da)Tools
A5UCX0 [UniParc].

Last modified July 10, 2007. Version 1.
Checksum: F26E2F599D15C611

FASTA43747,697
        10         20         30         40         50         60 
MNAYQNKNIT IIGLGKTGLS CVDYLLSQQA NIRVIDTRKK PTGIDKLPQN IPLHTGSLNQ 

        70         80         90        100        110        120 
EWLLESDMIV ISPGLAVKTP EIQTALKAGV EVIGDIELFC RAATKPIVGI TGSNGKSTVT 

       130        140        150        160        170        180 
TLVYEMAKAA GVKVGMGGNI GIPALSLLNE DCELYVLELS SFQLETTYSL KAAAATVLNV 

       190        200        210        220        230        240 
TEDHMDRYMD LEDYRQAKLR IYHNAEVGVL NNEDKLTFGE GENQARQTVS FAENSADYWL 

       250        260        270        280        290        300 
KTENGKQYLM VKDEVILPCE EATLVGRHNY MNILAATALA QAVGINLDAI RTALRHFKGL 

       310        320        330        340        350        360 
DHRFQLAHQA NGVRWINDSK ATNVGSTVAA LSGLYVEGKL HLLLGGDGKG ADFSELAELI 

       370        380        390        400        410        420 
NQPHIICYCF GRDGALLAKL SSQSYLFETM EQAIAFLRPT LQSGDMVLLS PACASLDQFA 

       430 
SFEKRGEEFT RLAQCLA

« Hide

References

[1]"Characterization and modeling of the Haemophilus influenzae core and supragenomes based on the complete genomic sequences of Rd and 12 clinical nontypeable strains."
Hogg J.S., Hu F.Z., Janto B., Boissy R., Hayes J., Keefe R., Post J.C., Ehrlich G.D.
Genome Biol. 8:R103.1-R103.18(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PittEE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000671 Genomic DNA. Translation: ABQ98621.1.
RefSeqYP_001291004.1. NC_009566.1.

3D structure databases

ProteinModelPortalA5UCX0.
SMRA5UCX0. Positions 4-437.
ModBaseSearch...

Protein-protein interaction databases

STRING374930.CGSHiEE_06370.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABQ98621; ABQ98621; CGSHiEE_06370.
GeneID5225602.
KEGGhip:CGSHiEE_06370.
PATRIC20278697. VBIHaeInf81350_1284.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0771.
HOGENOMHOG000049427.
KOK01925.
OMARCGELDV.
ProtClustDBPRK03806.

Enzyme and pathway databases

BioCycHINF374930:GJDD-1185-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.40.1190.10. 1 hit.
3.40.50.720. 1 hit.
3.90.190.20. 1 hit.
HAMAPMF_00639. MurD.
InterProIPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR016040. NAD(P)-bd_dom.
IPR005762. UDP-N-AcMur-Glu_ligase.
[Graphical view]
PANTHERPTHR23135:SF2. PTHR23135:SF2. 1 hit.
PfamPF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMSSF53244. Mur_ligase_C. 1 hit.
SSF53623. Mur_ligase_cen. 1 hit.
TIGRFAMsTIGR01087. murD. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMURD_HAEIE
AccessionPrimary (citable) accession number: A5UCX0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 10, 2007
Last modified: May 1, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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