A5UCQ6 (ACKA_HAEIE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetate kinase
EC=2.7.2.1

Alternative name(s):
Acetokinase

Gene names

Name:	ackA
Ordered Locus Names:	CGSHiEE_06020

Organism

Haemophilus influenzae (strain PittEE) [Complete proteome] [HAMAP]

Taxonomic identifier

374930 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	401 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + acetate = ADP + acetyl phosphate. HAMAP MF_00020 ATP + propanoate = ADP + propanoyl phosphate. HAMAP MF_00020
Pathway	Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2. HAMAP MF_00020
Subcellular location	Cytoplasm By similarity HAMAP MF_00020.
Sequence similarities	Belongs to the acetokinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	organic acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 401	401	Acetate kinase HAMAP MF_00020		PRO_1000002234

Sequences

	Sequence		Length	Mass (Da)
	A5UCQ6 [UniParc]. Last modified July 10, 2007. Version 1. Checksum: 4AA480395C178DA0	FASTA	401	43,645
	10 20 30 40 50 60 MSKLVLILNC GSSSLKFAIL DPATGEEKLS GLAEAFFLPE ARIKWKLNGE KGNADLGAGA 70 80 90 100 110 120 AHTEALNFIA SNILTDELKN SIAAIGHRIV HGGEKYTQSV IVTDEVVKGI EDAAQFAPLH 130 140 150 160 170 180 NPAHLIGIRE AFNAFPHLKD KNVVVFDTAF HQTMSEEAFL YALPYSLYKE HGVRRYGAHG 190 200 210 220 230 240 TSHYFISREV AEYVGKPADQ VNAIICHLGN GGSVSVVRNG QCIDTSMGLT PLEGLVMGTR 250 260 270 280 290 300 CGDIDPAIIF YLYKTLGMSM EQIEETLVKK SGLLGLTEVT SDCRYAEDNY DNASKPEAKR 310 320 330 340 350 360 ALNVYSYRLA KYIGAYMAVL GDDHLDAIAF TGGIGENSAH VRELALNHLK LFGIQIDNER 370 380 390 400 NLAARFGKDG VITTDDSAFK AIVLPTNEEL VIAQDTARLC F

References

[1]

"Characterization and modeling of the Haemophilus influenzae core and supragenomes based on the complete genomic sequences of Rd and 12 clinical nontypeable strains." Hogg J.S., Hu F.Z., Janto B., Boissy R., Hayes J., Keefe R., Post J.C., Ehrlich G.D. Genome Biol. 8:R103.1-R103.18(2007) [PubMed: 17550610] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PittEE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000671 Genomic DNA. Translation: ABQ98557.1.
RefSeq	YP_001290940.1. NC_009566.1.
3D structure databases
ProteinModelPortal	A5UCQ6.
ModBase	Search...
Protein-protein interaction databases
STRING	A5UCQ6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5226154.
GenomeReviews	Gene locus CGSHiEE_06020 in contig CP000671_GR.
KEGG	hip:CGSHiEE_06020.
PATRIC	20278552. VBIHaeInf81350_1212.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0282.
HOGENOM	HBG285863.
OMA	YLPEARI.
ProtClustDB	PRK00180.
Enzyme and pathway databases
BioCyc	HINF374930:CGSHIEE_06020-MONOMER.
Family and domain databases
HAMAP	MF_00020. Acetate_kinase. [Tree]
InterPro	IPR004372. Ac/Proprionate_kinase. IPR000890. Aliphatic_acid_kin_short-chain. IPR023865. Aliphatic_acid_kinase_CS. [Graphical view]
KO	K00925.
PANTHER	PTHR21060. Acetate_kin. 1 hit.
Pfam	PF00871. Acetate_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000722. Acetate_prop_kin. 1 hit.
PRINTS	PR00471. ACETATEKNASE.
TIGRFAMs	TIGR00016. AckA. 1 hit.
PROSITE	PS01075. ACETATE_KINASE_1. 1 hit. PS01076. ACETATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACKA_HAEIE

Accession

Primary (citable) accession number: A5UCQ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 10, 2007
Last modified:	December 14, 2011
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program