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Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Haemophilus influenzae (strain PittEE)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei138 – 1381UniRule annotation
Active sitei545 – 5451UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Carbon dioxide fixation

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

BioCyciHINF374930:GJDD-1095-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcUniRule annotation
Ordered Locus Names:CGSHiEE_05850
OrganismiHaemophilus influenzae (strain PittEE)
Taxonomic identifieri374930 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 879879Phosphoenolpyruvate carboxylasePRO_1000025560Add
BLAST

Proteomic databases

PRIDEiA5UCN0.

Structurei

3D structure databases

ProteinModelPortaliA5UCN0.
SMRiA5UCN0. Positions 4-879.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2352.
HOGENOMiHOG000238648.
KOiK01595.
OMAiCGMGVIA.
OrthoDBiEOG6TJ7T8.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5UCN0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQEYSTLRN NISMLGRFLG ETINDAQGED ILELIENIRK LSRNSRAGDD
60 70 80 90 100
KARQALLDTL GSISNENIIP VARAFSQFLN LTNIAEQYQT ISREHSLAQS
110 120 130 140 150
SSQSLSELFK RLKEQNASVE EVHKTVEKLL IELVLTAHPT ETTRRSLIHK
160 170 180 190 200
HIEINKCLSK LEHHDLTEKE RNIIERLLLR LIAEAWHTNE IRTVRPTPFD
210 220 230 240 250
EAKWGFAMLE NSLWQAVPEF LRQLNETARE FLGYDLPVGL KPVRISSWMG
260 270 280 290 300
GDRDGNPFVT AQITKKVLYF ARWKAADLFL QDISKLADEL SMMKCSDEFR
310 320 330 340 350
DKYGEHLEPY RFVVKNLRNQ LTATLAYFDD HLSNRTPRVS ESEIILEDNQ
360 370 380 390 400
LWEPLYDCYQ SLIQYGMRII ANGSLLNILH RISCFGVTLS QMDIRQESTR
410 420 430 440 450
HTDAIAEITR YIGLGDYAQW TEDDKQAFLI RELSSRRPLI PQNWTPSPET
460 470 480 490 500
QEILDTCKVI AQQKQGVIAC YVISMARNAS DVLAVHLLLK EAGVPYHIPV
510 520 530 540 550
VPLFETLEDL DAAEKVMTQL FNVGWYRGVI NNRQMVMIGY SDSAKDAGMM
560 570 580 590 600
AASWAQYRAQ EALVNLTEKL GIELTLFHGR GGTIGRGGAP AHAALLSQPP
610 620 630 640 650
RSLKNGLRVT EQGEMIRFKL GLPTVAVETF DLYASAILEA NLLPPPEPKP
660 670 680 690 700
EWRNIMDELS TISCDIYRGV VRGDKDFVPY FRSATPEQEL SKLPLGSRPA
710 720 730 740 750
KRNPNGGVES LRAIPWIFAW MQNRLMLPAW LGAGASIRQI IEQGKGDIIH
760 770 780 790 800
KMCENWPFFS TRIGMLEMVF SKSDTWLSQQ YDQRLVKKEL WYLGENLRKQ
810 820 830 840 850
LEDDIQTVLS LSHQSELMSD LPWIADSIAL RNIYTDPLNL LQVELLHRFR
860 870
ENPEQVNPDV EQALMITITG IAAGMRNTG
Length:879
Mass (Da):100,163
Last modified:July 10, 2007 - v1
Checksum:i857594007A8619FE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000671 Genomic DNA. Translation: ABQ98531.1.
RefSeqiWP_012054432.1. NC_009566.1.
YP_001290914.1. NC_009566.1.

Genome annotation databases

EnsemblBacteriaiABQ98531; ABQ98531; CGSHiEE_05850.
KEGGihip:CGSHiEE_05850.
PATRICi20278482. VBIHaeInf81350_1177.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000671 Genomic DNA. Translation: ABQ98531.1.
RefSeqiWP_012054432.1. NC_009566.1.
YP_001290914.1. NC_009566.1.

3D structure databases

ProteinModelPortaliA5UCN0.
SMRiA5UCN0. Positions 4-879.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiA5UCN0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABQ98531; ABQ98531; CGSHiEE_05850.
KEGGihip:CGSHiEE_05850.
PATRICi20278482. VBIHaeInf81350_1177.

Phylogenomic databases

eggNOGiCOG2352.
HOGENOMiHOG000238648.
KOiK01595.
OMAiCGMGVIA.
OrthoDBiEOG6TJ7T8.

Enzyme and pathway databases

BioCyciHINF374930:GJDD-1095-MONOMER.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characterization and modeling of the Haemophilus influenzae core and supragenomes based on the complete genomic sequences of Rd and 12 clinical nontypeable strains."
    Hogg J.S., Hu F.Z., Janto B., Boissy R., Hayes J., Keefe R., Post J.C., Ehrlich G.D.
    Genome Biol. 8:R103.1-R103.18(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PittEE.

Entry informationi

Entry nameiCAPP_HAEIE
AccessioniPrimary (citable) accession number: A5UCN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 10, 2007
Last modified: June 24, 2015
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.